: Impact of First-Pass Effect on Drug’s Bioavailability on Oral Administration by Medha __ https://padlet.com/medha6683/kwcl6tf4duxbnyrb Group assignment on Hepatic Clearance of Drugs en-us 2021-06-06 19:00:22 UTC 2021-06-08 05:39:24 UTC hello@padlet.com https://padlet.net/icons/png/1f48a.png Group: 02 medha6683 https://padlet.com/medha6683/kwcl6tf4duxbnyrb/wish/1588244767
  • 19146053       AARSHI MAHELAKA
  • 19146054   SUMAYA BINTY HUSSAIN
  • 19146055        NUZHAT TABASSUM
  • 19146056        MUMTAHINA SADIA
  • 19146057        NUSRAT JAHAN

    •  Submitted to
    Dr. Raushanara Akter
    Associate Professor
    Department of Pharmacy
    Brac University

    ]]>     2021-06-06 19:08:38 UTC https://padlet.com/medha6683/kwcl6tf4duxbnyrb/wish/1588244767     Main focus: https://padlet.com/medha6683/kwcl6tf4duxbnyrb/wish/1591997012
  • Drug taken orally, pass via liver before going systemic circulation, removed by metabolism or hepatobiliary secretion.
  • Factors - plasma protein concentration, enzymatic activity, gastriontestinal motility.
  • The drugs bioavailability may be considerably reduced.
  • First pass metabolism-
    • Swallowed drug→Digestive system→Hepatic portal system→Liver→Rest of the body
    ]]>     2021-06-08 05:33:55 UTC https://padlet.com/medha6683/kwcl6tf4duxbnyrb/wish/1591997012