Impact of First-Pass Effect on Drug’s Bioavailability on Oral Administration by Tahmid Ahmed https://padlet.com/tahmeeed/ss Group 8 Tahmid Ahmed Supto (19146046) Puja Biswas (19146091) en-us 2021-06-07 17:21:15 UTC 2023-05-06 22:25:45 UTC hello@padlet.com tahmeeed https://padlet.com/tahmeeed/ss/wish/1591751726 The first-pass effect happens when a drug is taken orally, enters the liver, and undergoes substantial biotransformation to the point where its bioavailability is substantially reduced, resulting in subtherapeutic activity]]> 2021-06-08 03:14:08 UTC https://padlet.com/tahmeeed/ss/wish/1591751726 tahmeeed https://padlet.com/tahmeeed/ss/wish/1592261889 2021-06-08 07:50:10 UTC https://padlet.com/tahmeeed/ss/wish/1592261889 https://padlet.com/tahmeeed/ss/wish/1592277773 How first pass effect reduce bioavailability of oral drugs? 

When drug enters the liver-
• it metabolises drugs to such an extent that only a small amount of active drug emerges from the liver to the systemic circulation
• thus greatly reduces the bioavailability of drugs .]]> 2021-06-08 07:58:53 UTC https://padlet.com/tahmeeed/ss/wish/1592277773 https://padlet.com/tahmeeed/ss/wish/1592325944 Examples -

•Remdesivir
•Morphine
•Propranolol
•Buprenorphine
 •Diazepam
]]> 2021-06-08 08:28:41 UTC https://padlet.com/tahmeeed/ss/wish/1592325944 https://padlet.com/tahmeeed/ss/wish/1592342597 A simple math to understand the impact of first pass effect on bioavailability of oral drugs ]]> 2021-06-08 08:38:28 UTC https://padlet.com/tahmeeed/ss/wish/1592342597 tahmeeed https://padlet.com/tahmeeed/ss/wish/1592463646 2021-06-08 10:00:34 UTC https://padlet.com/tahmeeed/ss/wish/1592463646 tahmeeed https://padlet.com/tahmeeed/ss/wish/1592466301 Group 8 sec 3
Puja Biswas -19146091
Tahmeed Ahmed -19146046
Billal Hossain Tusher -19146030
Submitted to -
Dr. Raushanara Akter ,
Associate Professor 
Department of pharmacy, 
Brac University ]]> 2021-06-08 10:02:53 UTC https://padlet.com/tahmeeed/ss/wish/1592466301 https://padlet.com/tahmeeed/ss/wish/1592490594 2021-06-08 10:23:13 UTC https://padlet.com/tahmeeed/ss/wish/1592490594