immuno A231 page 1 lesson 5 by https://padlet.com/trevortay/ke5j0icvweb5t55s en-us 2020-05-20 01:19:24 UTC 2025-12-19 15:58:16 UTC hello@padlet.com T Cell Activation yongxuanlim01 https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/583890508 - It is a 2 signal process
1st Signal: 
> Recognition and binding by TCR and co-receptor CD4/CD8 generates the 1st signal of T cell activation. 

2nd signal: Costimulation 
> Involves CD28 & B7(CD80)

]]> 2020-05-20 02:43:16 UTC https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/583890508 Lymphocyte vs Granulocyte 190231181 https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/583931650 Lymphocytes are mostly part of the innate system, excluding NK Cells. Included under this group are the B cells and T cells.
Granulocytes are part of the innate system. The cells included in this are Neutrophils, Eosinophils and Basophils.]]> 2020-05-20 03:32:19 UTC https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/583931650 MHC processing trevortay https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/584003710 it requires both the rough endoplasmic reticulum to manufacture the MHC proteins as well as the golgi apparatus for further processing of the MHC moleucule]]> 2020-05-20 05:00:35 UTC https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/584003710 Intracellular & Extracellular Antigen Processing roshniahrun123 https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/584025731
1. Endogenous Antigens (intracellular)

  • Tumor cells / cells infected by viruses or intracellular bacteria have antigens in the cytosol (endogenous antigens)
  • processed -->  presented on class I MHC -->  activates CD8 T cells 

2. Exogenous Antigens (extracellular)

  • Phagocytosed antigens from extracellular space --> digested by lysosomes -->  loaded into Class II MHC --> Activates T cells
]]> 2020-05-20 05:27:24 UTC https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/584025731 HLA molecules trevortay https://padlet.com/trevortay/ke5j0icvweb5t55s/wish/584037433 HLA stands for human leukocyte antigen which is also called the MHC receptors and are the same thing

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