MAPKs by https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94 en-us 2024-11-01 04:52:56 UTC 2024-11-01 15:41:21 UTC hello@padlet.com https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197825817 MAPK: swiss army knife of receptors

  • step 1: dimerization when ligand binds

  • unable to auto-phosphorylation

    • phosphorylates via Ykinase

  • step 2: intracellular signaling proteins bind

  • scaffold proteins bind SH3 domain

    • requires POSH

]]> 2024-11-01 15:14:21 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197825817 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197844867 Ligand - tyrosine kinase response - dimerization - cross phosphorylation - recruitment of scaffold proteins

]]> 2024-11-01 15:33:06 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197844867 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197845138 Traditional activation

Ligand - receptor dimerization - cross phosphorylation - recruitment of GRB2 SOS - activated RAS (GTP) - protein kinase

]]> 2024-11-01 15:33:17 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197845138 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197845239 Dimerize TKR, Phosphorylate, Then GRB2, SOS, then Ras GDP are recurited. Ras --> Raf --> MEK --> ERK. Then BOOOM CELL GROWTH

]]> 2024-11-01 15:33:19 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197845239 Traditional SOS https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197845996 Ligand binding, Dimerization, Cross phosphorylation, SOS, Ras, RAF, MEK, MAP, cell growth

]]> 2024-11-01 15:33:54 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197845996 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197846231 Can you briefly summarize the 3 steps of MAPK?

]]> 2024-11-01 15:34:08 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197846231 Ligand binds, dimerization of tyrosine kinase receptor, cross phosphorylation, GRB2 and SOS, ras! Cell proliferation! https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197847096 2024-11-01 15:34:54 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197847096 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197848351 Virus acts as the ligand

]]> 2024-11-01 15:36:07 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197848351 NS https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197848908 Connected to Ras-mitrogen activation, increase in activity leading to cell growth and proliferation causing hypertrophic cardiomyopathy

]]> 2024-11-01 15:36:42 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197848908 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197848916 hyperactive traditional pathway = increased cell growth and proliferation = cardio hypertrophy

]]> 2024-11-01 15:36:43 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197848916 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849039 Noonan is due to the traditional tyrosine receptor that leads to cell growth and proliferation in the heart. This leads to progressive hypertrophic cardiomyopathy.

]]> 2024-11-01 15:36:51 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849039 traditional TKRs activation https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849146 2024-11-01 15:36:54 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849146 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849513 Noonan syndrome

Mutations in genes controlling signaling proteins in the tyrosine kinase receptor pathways

Low set and rotated ears

]]> 2024-11-01 15:37:18 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849513 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849663 Uses both traditional and nontraditional pathways. traditional = cell growth. nontraditional = cell survivial.

]]> 2024-11-01 15:37:30 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849663 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849772 what does Metformin act on? the TKR itself, or its own receptor that activates IRS?

]]> 2024-11-01 15:37:38 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197849772 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197850649 BKPyV, EBV, Hep B all activate Ty-Kinase Trad. Pathway

]]> 2024-11-01 15:38:29 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197850649 https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197851918 Metformin increases insertion of glucose receptors in the membrane to increase glucose uptake in the presence of insulin. This works to decrease plasma glucose levels

]]> 2024-11-01 15:39:42 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197851918 BDNF https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197852344 Both traditional and nontraditional

Traditional- ligand, sos, RAS, RAF, MAP, Cell growth

Non-Traditional- Ligand, PI3K activation (by SH2 domain of p85), Akt, cell survival

]]> 2024-11-01 15:40:10 UTC https://padlet.com/sanromancellbiology/ja64nuoje0ku2u94/wish/3197852344