Autonomic Nervous System (2 of 2) by

Autonomic Nervous System (2 of 2) by https://padlet.com/p02012001/j11v0xxm5e5r Receptors and their Organ Response & Drug Classifications en-us 2020-02-18 17:15:54 UTC 2025-10-28 07:40:58 UTC hello@padlet.com Sympathetic Nervous System p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446951106 Adrenergic Division]]> 2020-02-18 17:19:57 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446951106 Parasympathetic Nervous System p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446951246 Cholinergic Division]]> 2020-02-18 17:20:08 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446951246 Alpha 1 p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952365 located on smooth muscle of the glands, eyes, most arteries and veins, urinary sphincter, GI sphincter]]> 2020-02-18 17:21:32 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952365 Alpha 2 p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952567 located on adrenergic nerve endings]]> 2020-02-18 17:21:44 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952567 Beta 1 p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952712 located on the heart]]> 2020-02-18 17:21:53 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952712 Beta 2 p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952786 located on smooth muscle of the lungs, uterus, skeletal muscle arteries, coronary arteries]]> 2020-02-18 17:21:59 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446952786 Muscarinic p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446963805 located on cardiac muscle, smooth muscle of GI tract (including glands), eyes, urinary bladder & sphincter, and lower respiratory passage.]]> 2020-02-18 17:38:16 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446963805 Nicotinic 1 (Nn) p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446964047 located at ganglia of parasympathetic and sympathetic nerves]]> 2020-02-18 17:38:39 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446964047 Nicotinic 2 (Nm) p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446964180 located in neuromuscular junction of skeletal muscle]]> 2020-02-18 17:38:49 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446964180 Alpha 1 stimulation by EPI and/or NE p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446982085 organ: arteries and veins
response: vasoconstriction
organ: urinary and GI tract
response: contraction of sphincters
organ: eyes
response: pupil dilation (mydriasis)
organ: apocrine glands
response: sweating

]]> 2020-02-18 18:05:42 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446982085 Alpha 2 stimulation by EPI and/or NE p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446988915 organ: adrenergic nerve ending
response: decrease release of NE]]> 2020-02-18 18:14:43 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446988915 Beta 1 stimulation by EPI p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446991985 organ: heart
response:

increase force of contraction (+ inotropic)
increase heart rate (+ chronotropic)
increase AV conduction (+ dromotropic)

]]> 2020-02-18 18:19:01 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446991985 Beta 1 stimulation by NE p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446997127 organ: heart
response:

moderate increase force of contraction (+ inotropic)
moderate increase heart rate (+ chronotropic)
moderate increase AV conduction (+ dromotropic)

]]> 2020-02-18 18:25:29 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446997127 Beta 2 stimulation by EPI (only) p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/446999121 organ: lung response: brochodilation
organ: uterus response: relaxation
organ: coronary arteries response: vasodilation
organ: skeletal muscle arteries response: vasodilation]]> 2020-02-18 18:28:13 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/446999121 Muscarinic stimulated by ACH p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447004231 organ: heart
response:
-slight decrease force of contraction (- inotropic)
-decrease heart rate (- chronotropic)
-decrease AV conduction (- dromotropic)
organ: eyes
response: pupil constriction (miosis)
organ: GI tract
response: increased motility and defecation
organ: GI glands
response: increased secretion
organ: lungs
response: bronchoconstriction
organ: urinary bladder
response: contraction, increased urinary flow
organ: urinary sphincter
response: relaxation, increased urinary flow]]> 2020-02-18 18:35:28 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447004231 Somatic Motor Division p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447020009 2020-02-18 18:57:55 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447020009 Nicotinic 1 stimulated by ACH p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447021914 organ: post ganglionic nerve fibers of parasympathetic and sympathetic nervous systems
response: transmit electrical impulse in post ganglionic nerve]]> 2020-02-18 19:00:28 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447021914 Alpha-1 Adrenergic Agonist p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447125982 Interacts: with alpha 1 receptors - stimulation
Actions:

contraction of smooth muscles
vasoconstriction -> increases BP
decongestant

Drug examples:

ephedrine
phenylephrine (Neo-Synephrine®)

]]> 2020-02-18 22:09:53 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447125982 Adrenergic Agonists p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447131453 Interacts: all alpha and beta receptors - stimulation
Actions:

vasoconstriction -> increases BP
cardiac stimulant
bronchodilator

Drug examples:
epinephrine (Adrenalin®)

]]> 2020-02-18 22:28:55 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447131453 SYMPATHOMIMETICS p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447133177 2020-02-18 22:35:37 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447133177 Beta 1 Adrenergic Agonist p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447133733 @ low dose:
interacts with dopaminergic (d-1) receptors in kidney, actions: vasodilation in kidneys -> increased renal blood flow
@ moderate dose:
interacts with beta 1 receptors, actions: increased force of contraction and cardiac output
@ high dose:
interacts with alpha 1 receptors, actions:
vasoconstriction -> increases BP

Drug examples: dobutamine

]]> 2020-02-18 22:37:16 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447133733 SYMPATHOLYTICS p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447141917 2020-02-18 23:05:01 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447141917 Beta 2 Adrenergic Agonist p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447141985 Interacts: with beta 2 receptors - stimulation
Actions:

relaxation of the smooth muscle of the lungs -> bronchodilation
relaxation of the smooth muscle of the uterus

Drug examples:

formoterol (Foradil®)
albuterol (Proventil®/Ventolin®)
terbutaline (Brethine®)

]]> 2020-02-18 23:05:17 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447141985 Alpha 1 Adrenergic Blocker p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447146748 Interacts: with alpha 1 receptors - blocking
Actions:

relaxation of smooth muscle
vasodilation -> decreases BP
relaxation of the ureters -> increased urine flow

Drug examples:

prazosin (Minipress®)
terazosin (Hytrin®)
doxazosin (Cardura®)

]]> 2020-02-18 23:21:46 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447146748 Selective Beta 1 Blocker p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447152969 Interacts: with beta 1 receptors - blocking
Actions:

decrease force of contraction (- inotropic)
decrease heart rate (- chronotropic)
decrease AV conduction (- dromotropic)
decreased cardiac output and BP

Drug examples:

atenolol (Tenormin®)
metoprolol (Lopressor®)

]]> 2020-02-18 23:46:32 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447152969 Non-selective Beta Blockers p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447155713 Interacts: with beta 1 and beta 2 receptors - blocking
Actions:

decrease force of contraction (- inotropic)
decrease heart rate (- chronotropic)
decrease AV conduction (- dromotropic)
decreased cardiac output and BP
can cause bronchoconstriction

Drug examples:

nadolol (Corgard®)
propranolol (Inderol®)
timolol (Blocadren®)

]]> 2020-02-18 23:57:44 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447155713 PARASYMPATHOMIMETICS p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447526793 2020-02-19 16:45:10 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447526793 Direct Acting Cholinergic Agonist p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447527909 Interacts: with muscarinic receptors - stimulation
Drugs examples and their actions:

acetylcholine constricts pupils -> miosis
pilocarpine (Pilocar®) constricts pupils and decreases intraocular pressure
bethanechol (Urecholine®) contraction of smooth muscle of the GI tract and urinary bladder -> increase urination and defecation

]]> 2020-02-19 16:46:36 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447527909 Indirect Acting Cholinergic Agonist p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447540013 Interacts: with acetylcholineterase - inhibition
Actions:
Inhibits the degradation of ACH in the synapse -> increases ACH
Drug example:
neostigmine (Prostigmin®)
Treats:

(muscarinic receptor sites) urinary retention, intestinal stasis/ileus
(nicotinic 2 or Nm receptor sites) reversal of anticholinergic Zemuron with respiratory paralysis from anesthesia; myasthenia gravis (autoimmune disease that attacks N2/Nm receptors and results in weak skeletal muscle

]]> 2020-02-19 17:01:38 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447540013 PARASYMPATHOLYTICS p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447570322 2020-02-19 17:38:58 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447570322 Anticholinergic p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/447571860 Interacts: with muscarinic receptors - blocker
Actions:
Blocks cholinergic receptors via competitive antagonism
Drug examples and their actions:

atropine increases HR, decreases vagus nerve activity (parasympathetic), slows digestion and urination, mydriasis
dicyclomine (Bentyl®) decreases GI secretions and motility
ipratropium bromide (Atrovent®) causes bronchodilation

]]> 2020-02-19 17:40:57 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/447571860 Source of information: p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448040904 -Pharmacology: An Introduction 7th Edition by Hitner, Henry & Nagle, Barbara
-ACC Lecture Notes]]> 2020-02-20 14:35:52 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448040904 Autonomic Nervous System p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448083099 Visceral Motor Division]]> 2020-02-20 15:26:22 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448083099 SKELETAL MUSCLE RELAXANTS - Peripheral Acting p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448087081 2020-02-20 15:31:08 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448087081 SKELETAL MUSCLE RELAXANTS - Centrally Acting p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448087743 MOA: Block conduction within the spinal cord by decreasing the number of impulses available to produce a contraction at motor neurons.
Drug examples:

cyclobenzaprine (Flexeril®)
carisoprodol (Soma®)
methocarbamol (Robaxin®)
orphenadrine citrate (Norflex®)
chlorzoxazone (Parafon Forte DSC®)
metaxalone (Skelaxin®)

]]> 2020-02-20 15:31:51 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448087743 Depolarizing Agent p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448088227 Interacts: with nicotinic 2 (Nm) receptors - depolarization
Drug and it's actions:
succinylcholine binds to nicotinic 2 receptors and induces depolarization (causing muscle fasciculations) while altering the receptor so that it can not respond to endogenous ACH and thus preventing contractions from occurring.]]> 2020-02-20 15:32:20 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448088227 Non-depolarizing Agent p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448088374 Interacts: with nicotinic 2 (Nm) receptors - blocks
Drug and it's actions:
rocuronium bromide (Zemuron®) binds to nicotinic 2 receptors and blocks ACH from binding, therefore preventing depolarization (i.e. muscle contraction)]]> 2020-02-20 15:32:32 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448088374 Direct Acting p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448088611 Interacts: with ryanodine receptors (i.e. calcium channel) - blocker
Drug and it's actions:
dantrolene inhibits skeletal muscle contraction by blocking Ca² ion release within the muscle fiber]]> 2020-02-20 15:32:49 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448088611 Nicotinic 2 (Nm) stimulated byACH p02012001 https://padlet.com/p02012001/j11v0xxm5e5r/wish/448213118 organ: skeletal muscles
response: contraction of motor skeletal muscle fibers (voluntary movement)]]> 2020-02-20 18:16:58 UTC https://padlet.com/p02012001/j11v0xxm5e5r/wish/448213118