https://padlet.com/75934/iwfz6ashci95 en-us 2016-02-24 19:29:17 UTC 2016-02-29 19:04:22 UTC hello@padlet.com 75934 https://padlet.com/75934/iwfz6ashci95/wish/97117935 Also called GM2 gangliosidosis
It is caused by an absence of vital enzyme Hex-A. 
Defects in a gene on chromosome 15 that codes for Hex-A

]]> 2016-02-24 19:50:00 UTC https://padlet.com/75934/iwfz6ashci95/wish/97117935 75934 https://padlet.com/75934/iwfz6ashci95/wish/97119487 - The fetus always suffers diminishing effects but shows no signs of them until 6 months.
- Babies appear normal until age 2 when their normal development slows.
- By age 2 most children experience seizures, blindness, deafness and do not respond to their environment,
- Children are paralyzed by age 3 and 4.
- Most die by age 5.
- There is no cure but gene therapy and enzyme replacement therapy may be the key to finding a cure. ]]> 2016-02-24 19:55:19 UTC https://padlet.com/75934/iwfz6ashci95/wish/97119487 98652 https://padlet.com/75934/iwfz6ashci95/wish/97121143 It is considered a autosomal recessive gene and occurs on chromosome 15. 
Children with tay sachs have a defect of a vital gene (Hex-a). 
http://www.cureangelman.org/images/15.jpg]]> 2016-02-24 20:00:59 UTC https://padlet.com/75934/iwfz6ashci95/wish/97121143 98652 https://padlet.com/75934/iwfz6ashci95/wish/97121473 It is inherited by a parent that carries the recessive gene. 
https://2011gtms8f.wikispaces.com/file/view/josh_s_punnett_square.PNG/230299570/400x299/josh_s_punnett_square.PNG]]> 2016-02-24 20:02:00 UTC https://padlet.com/75934/iwfz6ashci95/wish/97121473 98652 https://padlet.com/75934/iwfz6ashci95/wish/97122211

Most common in people with European Jewish descent 

• 1/27 Jews in US
• 1/50 Irish American in US 
• 1/250 General Population in US 
• 1/3,500 newborns in the world are diagnosed 

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There aren't very many prevention methods for the disease 

Test to see you are a carrier 

Make sure your partner isn't a carrier

You can get a Pre-implantation Genetic Diagnosis to avoid conceiving a child with the disease  

A woman can get a in-vitro fertilization 

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Consider a feeding tube to prevent choking on food

Respond to seizures in a timely fashion

Develop a respiratory health management plan with your pediatrician

Interact with your child to provide sensory stimulation  

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http://www.tay-sachs.org/taysachs_disease.php

http://www.mayoclinic.org/diseases-conditions/tay-sachs-disease/basics/definition/con-20036799

http://www.news-medical.net/health/Tay-Sachs-Disease-Prevention.aspx

https://www.ntsad.org/index.php/infantile-a-juvenile-support/symptom-management

http://www.ncbi.nlm.nih.gov/pubmed/11500789 

https://ghr.nlm.nih.gov/condition/tay-sachs-disease

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