Cystic Fibrosis by Kendall Griffith https://padlet.com/kengri2166/irwbkz4mi26g Lesson 4 Assignment en-us 2016-12-08 15:53:15 UTC 2016-12-08 17:55:47 UTC hello@padlet.com https://padlet-assets.s3.amazonaws.com/icons/Doubleheart.png What is Cystic Fibrosis? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142591319 Cystic fibrosis is an autosomal recessive disorder, meaning that is not inherited from the mother or father as in sex-linked disorders. It is a hereditary disease that causes the body to produce thick, sticky mucus that clogs the lungs and obstructs the pancreas. This genetic disease can be life threatening, and affects an estimated 30,000 children and adults in the United States alone. ]]> 2016-12-08 16:05:23 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142591319 At what age does it onset? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142592482 Most children are scanned for CF at birth and it is usually diagnosed by the age of 2]]> 2016-12-08 16:09:19 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142592482 What are the symptoms of the disorder? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142594287
  • Persistent coughing
  • Shortness of breath
  • Wheezing
  • Malabsorption caused by thick mucus may lead to malnutrition, poor growth, and weight loss.
  • Nasal polyps (small fleshy growths found in the nose)

    • ]]>     2016-12-08 16:14:41 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142594287     What causes CF? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142595417 Cystic fibrosis is an inherited condition. For someone to have CF, they need to inherit the defective gene from both of their parents. This gene is called the cystic fibrosis trans-membrane conductance regulator or CFTR gene. This gene is located on chromosome 7. 
    The defective gene codes for production of a protein that controls the flow of salt and water outside the organs, including the lungs and the pancreas. In CF, the balance of salt is distributed unevenly, leading to too little salt and water outside of the cells, resulting in the production of thicker mucus than normal.

    ]]>     2016-12-08 16:17:45 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142595417     What if two carriers have a child? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142599858
  • 25% (1 in 4) chance the child will have CF
  • 50% (1 in 2) chance the child will be a carrier but will not have CF
  • 25% (1 in 4) chance the child will not be a carrier and will not have CF.3
    • ]]>     2016-12-08 16:29:18 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142599858     What are the variables that affect how CF is expressed. kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142612327 Since the introduction of sweat testing, atypical individuals with some features of CF but with normal or borderline sweat tests have been reported. We now recognize that the spectrum of mutations in the CFTR gene gives rise to a very variable phenotype that may not be predictable from the individual’s genotype. It is believed that environmental factors and the influence of other modulator genes affect the ability of the CFTR genes to express their full disease potential.]]> 2016-12-08 17:01:29 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142612327 Can Parents be tested to see if they are carriers? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142615756 Yes, pregnant women can have a simple blood test to look for common mutations in her CFTR gene. If the mother has a “positive” prenatal screening, she carries one abnormal CFTR gene. There is a 50 percent chance that this CFTR gene will be passed on to the baby. If the mother is a carrier of a CFTR mutation, the father will also be tested. If he also carries a CFTR mutation, there is a 25 percent chance that the baby will have CF. ]]> 2016-12-08 17:11:25 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142615756 Can the disorder be detected before birth? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142617330
  • Yes, Chorionic villus sampling (also called CVS). This test checks tissue from the placenta for birth defects and genetic conditions. You can get CVS at 10 to 12 weeks of pregnancy.
  • Amniocentesis (also called amnio). This test checks amniotic fluid from the amniotic sac around your baby for birth defects and genetic conditions. You can get this test at 15 to 20 weeks of pregnancy.
    • ]]>     2016-12-08 17:15:50 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142617330     What environmental factors affect Cystic Fibrosis? kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142626998 Exposure to second hand cigarette smoke and stress affect/worsen the effects of CF

    ]]>     2016-12-08 17:40:47 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142626998     Treatment kengri2166 https://padlet.com/kengri2166/irwbkz4mi26g/wish/142629321 There is no cure for cystic fibrosis, but treatment can ease symptoms and reduce complications.
    Medications
    • Antibiotics to treat and prevent lung infections
    • Anti-inflammatory medications to lessen swelling in the airways 
    • Mucus-thinning drugs to help cough up the mucus, which can improve lung function
    • Inhaled medications called bronchodilators that can help keep airways open by relaxing the muscles around the bronchial tubes
    Therapy
    • Chest Physical Therapy 
    • Vest Therapy 
    • Pulmonary Rehabilitation
    ]]>     2016-12-08 17:46:58 UTC https://padlet.com/kengri2166/irwbkz4mi26g/wish/142629321