Parkinson's Disease by Andrea Halasz & Manuel Schön https://padlet.com/andyfely/insrfwyyjow7abeh Parkinson’s disease is a common neurodegenerative disease which mainly affects the motor system en-us 2021-03-23 16:48:39 UTC 2024-10-08 08:30:34 UTC hello@padlet.com https://padlet.net/icons/png/1f9e0.png CAUSES andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344034348 2021-03-23 16:53:16 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344034348 Genetical Factors andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344040135 Pointmutation on SNCA-Gen which codes for a protein called alpha-synuclein
  • misfolded or excess alpha-synuclein proteins can cluster together to lewy bodies
  • lewy bodies can disrupt the regulation of dopamine, which allows dopamine to accumulate to toxic levels and eventually kill neurons
]]> 2021-03-23 16:54:15 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344040135 Biological Factors andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344056526 Disorder of the basal ganglia causes the death of dopamine generating cells
Parkinson disease occurs when the nerve cells in the brain that make dopamine are slowly distroyed. Without dopamine, the nerve cells in the brainregion substantia nigrra cannot properly send messeges. This leads to a progressiv loss of muscle function.]]> 2021-03-23 16:56:59 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344056526 Enviromental Factors andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344123285 2021-03-23 17:07:54 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344123285 pesticides and herbicides andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344229794 Herbicides (eg paraquat) have been linked to cause Parkinson Disease.]]> 2021-03-23 17:25:11 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344229794 head injury andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344277064 Brain injury that results in alteration in level of consciousness — has been associated with an increased risk of developing Parkinson Disease years after the injury.]]> 2021-03-23 17:33:15 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344277064 andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344300361 2021-03-23 17:37:06 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344300361 SYMPTOMS andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344328789 2021-03-23 17:41:56 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344328789 Nomentor symptoms andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344432740
  • poor sense of smell
  • constipation
  • depression
  • cognitive
  • impairment
    • ]]>     2021-03-23 18:00:21 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344432740     Motor symptoms andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344439516
  • tremors
  • rigidity of limbs and trunk
  • difficulties with balance, speech, and coordination
  • Dyskinesia: involuntary, erratic writhing movements of the face, arms, legs or trunk.  
    • ]]>     2021-03-23 18:01:35 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344439516     andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344482848 2021-03-23 18:09:42 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344482848 TREATMENT andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344504633 2021-03-23 18:13:43 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344504633 No Cure, only symptomatic treatment andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344527621
  • supportive therapies, such as physiotherapy
  • medication
  • surgery (for some people)
    • ]]>     2021-03-23 18:18:05 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344527621     andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344560975 2021-03-23 18:24:36 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344560975 Medication andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344563570
    levodopa
    • absortion of Levodopa by the nerve cells
    • transformation of levodopa into dopamine

    dopamine agonists
    • substitute for dopamine

    monoamine oxidase-B inhibitors
    • they block the effects of an enzyme or brain substance that breaks down dopamine
     
    ]]>     2021-03-23 18:25:06 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344563570     AUSTRIAN INVOLVMENT andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344628341 2021-03-23 18:37:53 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344628341 Potential benefits from AFFITOME technology & SAIT andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344792530
  • Quarterly/twice-yearly dosing
  • one injection required per dose
  • physician adminstration enhances adherence
  • target-specific antibody response
  • long-lasting immune response
  • well-tolerated
    • ]]>     2021-03-23 19:12:18 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344792530     andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344809857 SAIT = Specific Active Immunotherapy
    • It is a  treatment that harnesses the power of the immune system 
    • rogue proteins that are involved with the development and progression of neurodegenerative diseases are targeted 
    AFFITOME Technology
    • creation of proteins with specific binding properties possible
    • these are ideally suited for the production of vaccines against diseases caused by dangerous endogenous proteins 

    ]]>     2021-03-23 19:16:23 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1344809857     SOURCES andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1347744120
    National Institutes of Health, "Parkinson Disease",
    https://rarediseases.info.nih.gov/diseases/10251/parkinson-disease [21.03.2021]

    medlineplus, "SNCA gene", https://medlineplus.gov/genetics/gene/snca/#conditions [24.03.2021]

    Parkinson Fundation, "Environmental Factors", https://www.parkinson.org/Understanding-Parkinsons/Causes/Environmental-Factors#:~:text=Scientists%20are%20working%20to%20better,environment%20can%20be%20quite%20complex. [21.03.2021] 


    National Institute of Environmental Health Sciences, "Parkinson's Disease and Environmental Factors", https://www.niehs.nih.gov/health/assets/docs_p_z/the_role_of_the_environment_in_parkinsons_disease_508.pdf [21.03.2021] 


    NHS, "Treatment - Parkinson Disease", https://www.nhs.uk/conditions/parkinsons-disease/treatment/ [21.03.2021]
    https://parkinsonsdisease.net/medications [21.03.2021]


    Parkinsondisease, "Medications Used to Treat Parkinson's", https://parkinsonsdisease.net/medications [21.03.2021]


    AFFiris, "Our Approch", https://affiris.com/ [24.03.2021]

    Images


    National Institute of Environmental Health Sciences, "Parkinson's Disease and Environmental Factors", https://www.niehs.nih.gov/health/assets/docs_p_z/the_role_of_the_environment_in_parkinsons_disease_508.pdf [21.03.2021]

    Parkinson Fundation, "Environmental Factors", https://www.parkinson.org/Understanding-Parkinsons/Causes/Environmental-Factors[ 21.03.2021] 

    Drjockers, https://drjockers.com/wp-content/uploads/2012/07/parkinson-brain5431.jpg [24.03.2021] 

    Frepik, "Parkinson's Disease symptoms", https://de.freepik.com/vektoren-kostenlos/parkinson-krankheit-symptome-infografik_9819299.htm [21.03.2021]

    Careageceneter, https://careagecenter.com/parkinson-disease/ [21.03.2021]

    Parkinsondisease, "Medications Used to Treat Parkinson's", https://parkinsonsdisease.net/medications [21.03.2021]

    AFFiris, https://affiris.com/ [24.03.2021]

    ]]>     2021-03-24 13:11:20 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1347744120     Parkinson’s disease is a common neurodegenerative disease which mainly affects the motor system andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1347975926 It progresses slowly as small clusters of dopaminergic neurons in the midbrain die. The loss of these neurons results in reduction of dopamine, a chemical responsible for transmitting messages to parts of the brain that coordinate muscle movement. Studies have shown that the symptoms of Parkinson’s usually appear when 50 percent or more of the dopamine neurons in the midbrain have been lost.]]> 2021-03-24 13:53:12 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1347975926 andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349019791 2021-03-24 16:55:36 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349019791 What is Parkinson's Disease ? andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349135142 2021-03-24 17:16:57 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349135142 andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349190627 Studies have shown that the symptoms of Parkinson’s usually appear when 50 percent or more of the dopamine neurons in the midbrain have been lost.]]> 2021-03-24 17:27:15 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349190627 andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349356305 2021-03-24 17:58:05 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349356305 andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349369637 2021-03-24 18:00:40 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1349369637 About AFFiRis andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1350002110 AFFiRis is a biopharmaceutical company located in Vienna . Its aim is to improve the lives of patients suffering from neurodegenerative diseases by providing disease-modifying specific active immunotherapies (SAIT) based on the company-own AFFITOME technology.]]> 2021-03-24 20:23:41 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1350002110 Sientific jargon andyfely https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1351856361 tremor…shaking, shiver
    rigidity...stiffness
    trunk...torso]]>     2021-03-25 09:05:49 UTC https://padlet.com/andyfely/insrfwyyjow7abeh/wish/1351856361