Outcome of Mutations Block 1 by Don Jarvie https://padlet.com/djarvie1/ia1grvl3ratknjw3 Post the information from your slide. Assignment 039 here. en-us 2021-03-22 18:43:13 UTC 2021-03-29 13:26:45 UTC hello@padlet.com extra toed cats https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357087119 2021-03-26 13:22:48 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357087119 variation https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357087760 2021-03-26 13:22:57 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357087760 they have 7 toes. The protein is called sonic hedgehog or SHH. The number of toes depends on their exposure to the protein. Normally, there is only SHH on one side of the foot, but extra-toes cats have it on both sides of their feet, so they have extra toes. https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357092775 2021-03-26 13:24:10 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357092775 mice, dogs, and chicken can have it https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357096380 2021-03-26 13:25:01 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357096380 red hair https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357103986 2021-03-26 13:26:32 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357103986 (RED HAIR) Both because people with variations of MC1R (along with at least 11 other genes) contribute to differences in hair and skin color. But redheads are at a high risk of getting skin cancer. https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357105445 2021-03-26 13:26:53 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357105445 jaguars,dark whiptail lizards, and many bird species https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357106558 RED HAIR]]> 2021-03-26 13:27:08 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357106558 Only 1-2% around the world. It's more common in Scotland and Ireland, where about 10-13% are redheads. Redheads normally have pale skin, light eyes and freckles.When different hormones inactivate the MC1R receptor. When MC1R When it's inactive, they make red pigments.Most redheads have one of three single-base variations in the MC1R gene. Each changes a single amino acid and affects how much MC1R gets to the cell surface and how it responds to signals. https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357109733 RED HAIR]]> 2021-03-26 13:27:51 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357109733 Red Hair https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357110522 2021-03-26 13:28:02 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357110522 Both https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357111677 2021-03-26 13:28:17 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357111677 The affected protein in redheads is MC1R (melanocortin 1 receptor). MC1R sits in the membrane of specialized skin cells that make pigments. Pigments give skin and hair their color. Different hormones activate or inactivate the MC1R receptor. When MC1R is active, cells make black pigments. When it's inactive, they make red pigments. https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357117009 2021-03-26 13:29:25 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357117009 dark whiptail lizards,many bird species, and jaguars https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357120275 2021-03-26 13:30:08 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357120275 Shar Pei Dog https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357126983 2021-03-26 13:31:35 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357126983 Shar Pei Dog: Both. Beacuse this variation in skin architecture is not a health problem. However hyaluronan can cause an immune response, leading to skin inflammation and fever. https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357128060 2021-03-26 13:31:49 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357128060 Shar Pei Dog: Hyaluronan Synthase 2. It is an enzyme that sits in the membrane of skin cells. It builds a large molecule called hyaluronan (HA) and releases it outside the cell. https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357131229 2021-03-26 13:32:30 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357131229 Shar Pei Dog: Naked Mole Rat https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357132347 2021-03-26 13:32:45 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357132347 extra toed cats https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357178125 2021-03-26 13:42:34 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357178125 estra toed cats https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357181485 variation]]> 2021-03-26 13:43:16 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357181485 extra toed cats https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357188737 The cat grow 2 extra toes on the thumb side of the paw

This is the SHH gene it allows fingers and toes to be made depending on how much of the gene they are exposed to. The cat can grow 7 toes because the cat has the gene exposed on both sides and not just one side, so extra toes grow.

]]> 2021-03-26 13:44:47 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357188737 extra toed cats https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357190370 All vertebrates can have this disease, this can cause humans to have 2 thumbs, also  mice, cats, and chicken can all have extra toes. ]]> 2021-03-26 13:45:07 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357190370 Extra toed cats https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357206914 2021-03-26 13:48:53 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357206914 Variation https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357208560 2021-03-26 13:49:11 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357208560 Extra toed cats: What the protein is called and how it works. (Summarize the Protein and DNA sections)The protein is called SHH(Sonic hedgehog) and it is made by cells. There's a single-base change outside of the protein-coding and the SHH gene makes a new switch that turns the SHH gene on the other side of the foot. For mitten cats, they make SHH protein on both sides of the foot causing to make extra toes. https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357209257 2021-03-26 13:49:20 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357209257 Dogs, chickens, mouse, and humans https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357210777 2021-03-26 13:49:40 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1357210777 double muscled cattle https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1363999007 2021-03-29 13:26:14 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1363999007 variation https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1363999669 2021-03-29 13:26:24 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1363999669 They have double the muscle and half the fat as other breeds of cows. the protein is called myostatin. Normally, myostatin attaches to a pair of receptors on a muscle cell to tell it to stop growing the cell. These cows don’t have enough myostatin or even any at all so their muscles keep growing https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1364000537 2021-03-29 13:26:36 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1364000537 sheep, mice, humans https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1364000949 2021-03-29 13:26:40 UTC https://padlet.com/djarvie1/ia1grvl3ratknjw3/wish/1364000949