Crohn's Disease Research Project by Tyler Chin-Aleong

Who first discovered this disorder?

chinaleongt1 — 2024-05-06 14:07:37 UTC

Reports of sickness with similar symptoms to ulcerative colitis go way back, even before the Civil War, but it wasn't called a separate disease until 1875. Crohn's disease was first talked about in 1932 by three doctors named Burrill Crohn, Leon Ginzberg, and Gordon D. Oppenheimer.

What are the symptoms/characteristics associated with this disorder?

chinaleongt1 — 2024-05-06 14:09:27 UTC

The symptoms can come on gradually, but they can also show up suddenly. These can include diarrhea, fever, fatigue, abdominal pain and cramping, blood in your stool, mouth sores, reduced appetite, and weight loss.

At what age do the symptoms begin?

chinaleongt1 — 2024-05-06 14:10:28 UTC

While many individuals are diagnosed in their 20s, there is also a spike in the frequency of Crohn's diagnosis between the ages of 60 to 80. Many people begin to experience their first symptoms somewhere in their 50s to 70s.

Are the symptoms treatable? If so, how?

chinaleongt1 — 2024-05-06 14:11:34 UTC

There is currently no cure, but many treatments can provide a lot of relief, and in some cases, even long-term remission. These may include anti-inflammatory drugs like corticosteroids, immune system suppressants, and antibiotics.

Is the disorder fatal?

chinaleongt1 — 2024-05-06 14:14:10 UTC

Crohn's disease is not fatal, but it can have a severe impact on a person's quality of life. For some people, Crohn's disease gradually gets worse as time goes by. One reason for this is the damage that long-lasting inflammation can do to your digestive tract. To stop that from happening, your doctor will try to get your condition under control early on.

What is the inheritance pattern of the disorder: dominant, recessive, sex-linked, autosomal, other?

chinaleongt1 — 2024-05-06 14:15:37 UTC

The inheritance pattern of Crohn's disease is unclear because many genetic and environmental factors are likely to be involved. However, Crohn's disease tends to cluster in families; about 15 percent of affected people have a first-degree relative (such as a parent or sibling) with the disorder.

Psychological Stress

chinaleongt1 — 2024-05-06 14:17:50 UTC

Psychological stress is defined as “a particular relationship between the person and the environment that is appraised by the person as taxing or exceeding his or her resources and endangering his or her well-being”.

Viruses

chinaleongt1 — 2024-05-06 14:18:52 UTC

The issue of Polyomaviruses and their potential impact on individuals with Crohn's disease has been a topic of interest in previous published studies, wherein it was observed that such viruses were detected at higher rates in the intestinal tissues of patients with Crohn's disease when compared to healthy individuals.

Smoke

chinaleongt1 — 2024-05-06 14:19:52 UTC

People who smoke have more severe Crohn's disease symptoms and more relapses. Smoking doesn't change how Crohn's disease medicine works, but it might make treatment less effective at putting the disease into remission.

How many people are affected and where in the world is it most relevant

chinaleongt1 — 2024-05-06 14:21:26 UTC

Crohn's disease is most common in Western Europe and North America, where it has a prevalence of 100 to 300 per 100,000 people. More than half a million Americans are currently affected by this disorder.

Which chromosome(s) is responsible for this disorder

chinaleongt1 — 2024-05-06 14:24:04 UTC

Genetic variants associated with Crohn's disease have now been identified on chromosomes 5 ( IBD5 / 5q31 risk haplotype) and 16 ( IBD1 locus, CARD15 / NOD2 mutations). This means that it affects 2 chromosomes.

What tests are done to confirm a diagnosis of this disorder?

chinaleongt1 — 2024-05-06 14:25:26 UTC

Intestinal endoscopy. Intestinal endoscopies are the most accurate methods for diagnosing Crohn's disease and ruling out other possible conditions, such as ulcerative colitis, diverticular disease, or cancer.

It is a Gene Mutation

chinaleongt1 — 2024-05-06 14:26:54 UTC

The causes of Crohn's disease are complex. This condition results from a combination of genetic, environmental, and lifestyle factors, many of which are unknown.

Which gene is involved?

chinaleongt1 — 2024-05-06 14:27:17 UTC

Many of the major genes related to Crohn's disease, including NOD2, ATG16L1, IL23R, and IRGM, are involved in immune system function.

chinaleongt1 — 2024-05-06 14:52:53 UTC