https://padlet.com/14estesjt/essay4 Brainy Buildup en-us 2019-11-20 17:48:35 UTC 2025-12-21 02:27:22 UTC hello@padlet.com https://padlet-uploads.storage.googleapis.com/433696203/92c320c28070338f78a0137af60e5c4b/1464677311.jpg 14estesjt https://padlet.com/14estesjt/essay4/wish/414182887 Focusing mainly on the effects of lack of sleep, the article illustrates this through mice. During sleep, the brain is capable of cleaning itself out. But when it is awake, this process is much slower and definitely less effective. 8-10 hours of sleep a night is important in order to get a good night's rest as well as allow the brain time to clean itself. This is important for later in life. In a series of new studies on mice, her team discovered exactly that: When the mouse brain is sleeping or under anesthesia, it’s busy cleaning out the waste that accumulated while it was awake.

]]> 2019-11-20 17:58:36 UTC https://padlet.com/14estesjt/essay4/wish/414182887 14estesjt https://padlet.com/14estesjt/essay4/wish/414183808 The article goes more into depth about why teens/young adults can’t get enough sleep, and what happens to their brains as a result. They become more tired and less able to concentrate when they get less than 8-10 hours of sleep a night. This is also important to prevent the breakup of the beta amyloid fluid in the brain. This buildup can cause harmful diseases later in life. I also know that my own choices of going to hang with friends or working out cause me sleep deprivation. To be at your best, you need between 8 and 10 hours of sleep every day. While you might not always be able to get this much, it’s important to try and get as much as you can.

]]> 2019-11-20 17:59:45 UTC https://padlet.com/14estesjt/essay4/wish/414183808 14estesjt https://padlet.com/14estesjt/essay4/wish/414184471 Lack of sleep can cause harmful brain diseases like Alzheimers. Several researchers including Dr. Nedergaard are interviewed and they give their expert opinion on the matter. The excess buildup almost guarantees some health risk later in life, and this is all caused by not sleeping enough. I wonder if the brain can remove plaque buildup on its own, or surgery or something like that is required. I’m curious because I know the process was done in mice but not yet in humans. 

That's because one of the waste products removed from the brain during sleep is beta amyloid, the substance that forms sticky plaques associated with the disease.

]]> 2019-11-20 18:00:42 UTC https://padlet.com/14estesjt/essay4/wish/414184471 14estesjt https://padlet.com/14estesjt/essay4/wish/414186304 Scientists found it was possible to reverse the amyloid plaques in mice, which is a huge breakthrough. This is a step towards eventually removing alzheimers. Removal of the beta amyloid plaque buildup allows the brain to better communicate with itself, as well as having cognitive improvement. I know that by not getting enough sleep, the brian starts to breakdown, and causes excess buildup. However, through this article I learned it may be possible to reverse the buildup in humans because it was possible in mice. One of the most concrete ways in which Alzheimer’s is identified in a patient is through an abnormal buildup of beta-amyloid peptide, a protein that can build into the large amyloid plaques in the brain that are a telltale sign of the deadly, and to date incurable disease.]]> 2019-11-20 18:03:19 UTC https://padlet.com/14estesjt/essay4/wish/414186304 14estesjt https://padlet.com/14estesjt/essay4/wish/414189138 Eagleman gives us background knowledge on the brain. He provides countless examples to represent his findings, which makes it easy to read as a reader. His book helped me connect different concepts, especially having to do with the location of where different brain functions take place. “I’m still figuring out which quotes I may want to use.”

]]> 2019-11-20 18:06:51 UTC https://padlet.com/14estesjt/essay4/wish/414189138 14estesjt https://padlet.com/14estesjt/essay4/wish/414199624 There are two important brain proteins that appear as a result of lack of sleep: beta amyloid and tau. The buildup of these proteins cause almost a 3 times greater chance of having a harmful diseases later in life. People who don't get the required amount of sleep put them self at risk. Does the buildup of these plaques go at a more rapid pace as more is built up, or does it maintain a steady build up pace? No one knows for sure what comes first: Do excess beta-amyl-oid and tau impair sleep, or does impaired sleep lead to a buildup of these proteins? The leading hypothesis is that it goes both ways in a kind of vicious cycle.

]]> 2019-11-20 18:17:50 UTC https://padlet.com/14estesjt/essay4/wish/414199624 14estesjt https://padlet.com/14estesjt/essay4/wish/421631213 This essay dives deep into a fluid called beta amyloid, and it's effect on the brain. It also shows the result of a lack on sleep, and the long term effects it has on a humans health. Is there a way to clear this fluid at a faster rate while we are awake? Multiple experts in the field conclude that there is a relationship between the buildup of the beta amyloid fluid and dangerous diseases]]> 2019-12-09 15:02:20 UTC https://padlet.com/14estesjt/essay4/wish/421631213 14estesjt https://padlet.com/14estesjt/essay4/wish/422565277 The TED talk I watched gives visuals and an in depth look at what happens in the brain during the day while you are awake, and at night when sleeping. I wonder if it will ever be possible to have more cerebrospinal fluid enter the brain during times of awakeness]]> 2019-12-11 05:21:27 UTC https://padlet.com/14estesjt/essay4/wish/422565277 14estesjt https://padlet.com/14estesjt/essay4/wish/422717635 Discussed in the web-based article is the direct link between beta amyloid and Alzheimers. Mice are again the testing experiment, and it proves how vital sleep is to clear the brain of the  harmful waste. The writer even talks about genetically modifying the mice, would this help humans as well?... Our discovery suggests that Alzheimer’s disease starts to manifest long before plaque formation becomes evident,]]> 2019-12-11 14:21:31 UTC https://padlet.com/14estesjt/essay4/wish/422717635