https://padlet.com/2019jacobobarja/hc2gvqssojhe Made with joy en-us 2017-11-16 14:21:11 UTC 2025-10-30 15:56:08 UTC hello@padlet.com https://padlet-assets.s3.amazonaws.com/icons/Soccerball.png 2019jacobobarja https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/207698394 ^{Leigh syndrome is a severe neurological disorder that usually becomes apparent in the first year of life. This condition is characterized by progressive loss of mental and movement abilities (psychomotor regression) and typically results in death within two to three years, usually due to respiratory failure. The most common treatment for Leigh's disease is thiamine or Vitamin B1. Oral sodium bicarbonate or sodium citrate may also be prescribed to manage lactic acidosis. Researchers are currently testing dichloroacetate to establish its effectiveness in treating lactic acidosis. In individuals who have the X-linked form of Leigh's disease, a high-fat, low-carbohydrate diet may be recommended.}]]> 2017-11-16 15:02:20 UTC https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/207698394 2019jacobobarja https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/207707094 ^{The mitochondrion is a double membrane organelle found in all eukaryotic organism. Some cells in some multicellular organism may however lack them, for example "red blood cells"}]]> 2017-11-16 15:14:05 UTC https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/207707094 2019jacobobarja https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/207717180 2017-11-16 15:28:28 UTC https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/207717180 2019jacobobarja https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210172521 ^{Mitochondrial DNA associated Leigh Syndrome is a subtype of Leigh Syndrome and is caused by changes in mitochondrial DNA. Mutations in at least 11 mitochondrial genes have been found to cause mtDNA associated Leigh Syndrome. This condition has an inheritance pattern know as maternal or mitochondrial inheritance. Because mitochondria can be passed from one generation to the next only through egg cells (not through sperm cells), only females pass Mitochondrial DNA-associated Leigh Syndrome to their child}]]> 2017-11-26 17:53:38 UTC https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210172521 2019jacobobarja https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210189889 ^{Mitochondria use oxygen to convert the energy from food into a form cells can use through a process called oxidative phosphorylation. Five protein complexes, made up of several proteins each, are involved in this process. The complexes are named complex I, complex II, complex III, complex IV, and complex V. During oxidative phosphorylation, the protein complexes drive the production of adenosine triphosphate (ATP), the cell's main energy source, through a step-by-step transfer of negatively charged particles called electrons. Many of the gene mutations associated with Leigh syndrome affect proteins in these complexes or disrupt their assembly. These mutations reduce or eliminate the activity of one or more of these complexes, which can lead to Leigh syndrome.}]]> 2017-11-26 19:39:45 UTC https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210189889 2019jacobobarja https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210216266 https://rarediseases.org/rare-diseases/leigh-syndrome/

https://rarediseases.info.nih.gov/diseases/3671/maternally-inherited-leigh-syndrome

https://en.wikipedia.org/wiki/Leigh_disease]]> 2017-11-26 23:05:40 UTC https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210216266 2019jacobobarja https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210226026 nothing happened because the cure is vitamin etc.]]> 2017-11-27 00:41:57 UTC https://padlet.com/2019jacobobarja/hc2gvqssojhe/wish/210226026