My epic canvas by Darx Chris

My epic canvas by Darx Chris https://padlet.com/903102883/h7ic305az8nl Made with ♥ en-us 2018-10-11 06:23:37 UTC 2025-10-25 00:29:58 UTC hello@padlet.com https://padlet-assets.s3.amazonaws.com/icons/Doubleheart.png CSB 349 PBL Project 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291570344 sarahm.jun@mail.utoronto.ca

Topic: ACAP2 gene regulations and implications in ZGA and MZT

]]> 2018-10-11 06:27:01 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291570344 Human CNT-1 Homolog ACAP2has a Pro-Apoptotic Role inCancer Cells 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291823147 ACAP2 is a demonstratedRAB35 effector and a GTPase activatingprotein (GAP) for ARF6.24-26 Wefocused our studies on ACAP2 andACAP3, as these proteins display themost significant homology with CNT-1(33% identical, 50% similar and 35%identical, 53% similar, respectively), especiallywithin their PH domains (52%identical, 75% similar and 52% identical,76% similar, respectively, Fig. 1B),which is the critical domain for tCNT-1-mediated AKT inactivation.]]> 2018-10-11 16:20:11 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291823147 Rab35 regulates Arf6 activity through centaurin-b2(ACAP2) during neurite outgrowth (essential factors for neurite outgrowth) 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291827481 centaurin-b2 (also known as ACAP2) functions both as a Rab35 effector and as an Arf6-GTPase-activating protein (GAP) during neurite outgrowth of PC12 cells.
Rab35 accumulates at Arf6-positive endosomes in response to nerve growth factor (NGF) stimulation and that centaurin-b2 is recruited to the same compartment in a Rab35-dependent manner. We further showed by knockdown and rescue experiments that after the Rab35-dependent recruitment of centaurin-b2, the Arf6-GAP activity of centaurin-b2 at the Arf6-positive endosomes was indispensable for NGF-induced neurite outgrowth. These findings suggest a novel mode of crosstalk between Rab and Arf: a Rab effector and Arf-GAP coupling mechanism, in which Arf-GAP is recruited to a specific membrane compartment by its Rab effector
function]]> 2018-10-11 16:26:50 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291827481 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291830684 2018-10-11 16:32:25 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291830684 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291831231 2018-10-11 16:33:32 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291831231 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291831678 2018-10-11 16:34:21 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291831678 Rab35 regulates phagosome formation throughrecruitment of ACAP2 in macrophages duringFccR-mediated phagocytosis 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291832982 2018-10-11 16:36:44 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291832982 903102883 https://padlet.com/903102883/h7ic305az8nl/wish/291833544 2018-10-11 16:37:45 UTC https://padlet.com/903102883/h7ic305az8nl/wish/291833544