AML CONCEPT MAP by Hajar Qaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e H&L MODULE en-us 2021-09-26 03:23:09 UTC 2026-01-03 12:00:48 UTC hello@padlet.com https://padlet.net/icons/png/1f993.png Acute Myeloid Leukaemia (AML) hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458117410 2023-01-26 19:29:47 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458117410 Accumulation of genetic abnormalities in the original myeloid precursor cells (blast) hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458129944 2023-01-26 19:40:15 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458129944 Neoplastic myeloid precursor cells (blasts) divide & accumulate in the bone marrow hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458134559 2023-01-26 19:44:10 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458134559 Abundant blasts displacing other blood cell precursors in the marrow, inhibiting their development hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458141324 2023-01-26 19:49:33 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458141324 After the neoplastic blasts fill up the bone marrow, they spill out into the blood hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458143291 2023-01-26 19:51:13 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458143291 High turnover of the neoplastic blastic cells hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458145580 2023-01-26 19:53:09 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458145580 Multifactorial causes , most with unclear mechanisms hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458147170 2023-01-26 19:54:25 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458147170 Expanding marrow pushing on bone hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458147520 2023-01-26 19:54:45 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458147520 Pancytopenia on FBC hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458149088 2023-01-26 19:55:55 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458149088 >20% of marrow consists of BLASTS hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458150217 on bone marrow aspirate/ biopsy]]> 2023-01-26 19:56:59 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458150217 Blasts are detected as WBC on FBC hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458150805 2023-01-26 19:57:33 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458150805 Neoplastic blasts secrete excessive amounts of coagulation-promoting cytokines into circulation hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458152540 2023-01-26 19:59:05 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458152540 Myeloid cells normally produce intracellular granules, which precipitate inside immature blasts to form rods hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458154262 2023-01-26 20:00:12 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458154262 High rate of cell lysis hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458155554 2023-01-26 20:01:23 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458155554 Low neutrophils hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458156790 2023-01-26 20:02:38 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458156790 Low RBCs hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458157127 2023-01-26 20:02:59 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458157127 Low platelets, reduced clotting ability hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458157584 2023-01-26 20:03:28 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458157584 Bone pain hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458160934 2023-01-26 20:06:45 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458160934 Susceptible to infections hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458161655 2023-01-26 20:07:30 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458161655 Anaemia hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458161985 2023-01-26 20:07:49 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458161985 Fatigue, shortness of breath, pallor hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458162934 2023-01-26 20:08:35 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458162934 Easy bruising & petechiae on the skin hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458163837 2023-01-26 20:09:08 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458163837 May cause LEUKOCYTOSIS despite pancytopenia hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458165672 2023-01-26 20:10:55 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458165672 ⚠⛔ DISSEMINATED INTRAVASCULAR COAGULATION (DIC) ⚠⛔ hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458168181 2023-01-26 20:12:45 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458168181 Auer rods in myeloblasts hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458170156 2023-01-26 20:14:58 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458170156 Release of intracellular contents hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458171323 IE; Uric acid, K+, LDH into plasma]]> 2023-01-26 20:16:11 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458171323 Hyperuricemia hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458173565 2023-01-26 20:18:30 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458173565 HyperKalemia & High [LDH] hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458174436 2023-01-26 20:19:22 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458174436 Acute kidney injury hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458175089 2023-01-26 20:20:00 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458175089 Gout hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458175370 2023-01-26 20:20:14 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458175370 Weight loss, fever, malaise, fever, chills, night sweats hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458178918 2023-01-26 20:23:41 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458178918 Pathogenesis: hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458184361 2023-01-26 20:29:07 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458184361 Risk factors: hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458187240
  • Median onser: 65 y/o
  • Genetic factors ie; DOWNS SYNDROME
  • Environmental exposures; Radiation, Chemotherapy, Benzene
  • Has underlying haemopoietic neoplasms; ie: Myelodysplasia, Myeloproliferative neoplasms.
    • ]]>     2023-01-26 20:31:50 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458187240     Lists of recurrent genetic abnormalities in AML hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458190909 2023-01-26 20:35:40 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458190909 Clinical features: hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458196147
  • Bone marrow failure
  • Frequent infection, thrombocytopenia & anaemia
  • Gum hypertrophy
  • CNS effects, ie, headache and diplopia but less likely compared to ALL
    • ]]>     2023-01-26 20:41:06 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458196147     ⛔⚠ APML, Acute Promyelocytic Leukaemia⚠⛔ hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458198710
    ⛔MEDICAL EMERGENCY; as it is associated with
    1. High incidence of DIC
    2. Spontaneous bleeding into vital organs
    **translocation in Chromosome (15, 17)
    ]]>     2023-01-26 20:44:04 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458198710     Observation on AML hajarqaireine https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458209005 2023-01-26 20:56:40 UTC https://padlet.com/hajarqaireine/h4ql3e2wssm1w59e/wish/2458209005