Lou Gehrig's Disease by Harry Jachec https://padlet.com/1514971/LOU_GEHRIG en-us 2019-01-30 02:05:47 UTC 2026-03-17 21:01:16 UTC hello@padlet.com What is Lou Gehrig's Disease? 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/325686869 Lou Gehrig's Disease is a progressive neurodegenerative disease that affects nerve cells in the brain and the spinal cord. ]]> 2019-01-30 02:50:25 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/325686869 What Else is is Called? 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/325834235 Lou Gehrig's Disease is also known as ALS, or amyotrophic lateral sclerosis and comes in two types, sporadic and familial.]]> 2019-01-30 14:11:02 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/325834235 Who Discovered ALS? 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/325835221 ALS was first viewed by a french neurologist by the name of Jean-Martin Charcot in 1869.]]> 2019-01-30 14:13:16 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/325835221 Who was it named after 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/325840878 Lou Gehrig's Disease is named after a famous baseball player who contracted the disease and had to retire in 1939.]]> 2019-01-30 14:25:22 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/325840878 What is a quick description of the disease? 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/325842635 ALS is a genetic disease that causes degrading muscle strength over time after the gene shows itself.]]> 2019-01-30 14:28:39 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/325842635 What about the genetic side of ALS? 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/326051745 One type of ALS, familial ALS is caused by a gain of a new and toxic function of the superoxide dismutase 1 (SOD1) protein is probably how mutation of the SOD1 gene causes ALS. With normal amounts of the enzyme, superoxide dismutase breaks down toxic oxygen molecules that are produced by normal cell processes, but when the SOD1 gene is altered, it impairs the function of this enzyme, and the toxic molecules continue to cause harm to the cells]]> 2019-01-30 21:21:08 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/326051745 How is ALS passed down? 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/326053802 ALS can be passed down if the parents have ALS or if the causing mutation occurs in a sperm or egg cell.]]> 2019-01-30 21:27:50 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/326053802 Detection of ALS 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/326054776 So far, ALS is not able to be detected before symptoms arise, but it is more common in members of the armed forces and professional athletes. After symptoms arise, you can be genetically tested for a mutation to the SOD1 gene to tell the variant of the disease. This is done through taking a buccal swab or some other DNA test.]]> 2019-01-30 21:31:04 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/326054776 Clinical Description 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/326513487 The main features of ALS are:

  • Difficulty walking or doing your normal daily activities.
  • Tripping and falling.
  • Weakness in your leg, feet or ankles.
  • Hand weakness or clumsiness.
  • Slurred speech or trouble swallowing.
  • Muscle cramps and twitching in your arms, shoulders and tongue.
]]> 2019-01-31 22:47:12 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/326513487 Clinical Description 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/326655510 ALS comes with almost-certain chances of death, and most patients die within 2-5 years of being diagnosed. ]]> 2019-02-01 12:46:47 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/326655510 Treatment 1514971 https://padlet.com/1514971/LOU_GEHRIG/wish/326658691 Although there is no known cure for ALS, the drug riluzole has been approved for treatment and may slow progression of the disease. It is expensive, however, and appears modestly effective. Generally, treatment is designed to help control symptoms.]]> 2019-02-01 12:58:40 UTC https://padlet.com/1514971/LOU_GEHRIG/wish/326658691