https://padlet.com/williamerichuff/gyro7ak7f3zk Using physical binding to improve tumor targeting nanoparticles en-us 2018-07-25 23:19:00 UTC 2024-10-13 23:51:50 UTC hello@padlet.com https://padlet-uploads.storage.googleapis.com/302032976/4b51a4d955b60ff5495bc77213ae533c/nanosubmarines.jpg williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271138824 Scientists at the Mainz University Medical Center and the Max Planck Institute for Polymer Research (MPI-P) have developed a new method to attack tumors using improved nanocarrier technology.  The nanocarrier is combined with antibodies under acidic conditions to allow it to dock on immune cells, which in turn attack tumors. ]]> 2018-07-26 00:33:43 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271138824 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271142392 2018-07-26 01:04:22 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271142392 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271143412 Tonigold, M., Simon, J., Estupiñán, D., Kokkinopoulou, M., Reinholz, J., Kintzel, U., . . . Mailänder, V. (2018). Pre-adsorption of antibodies enables targeting of nanocarriers despite a biomolecular corona. Nature Nanotechnology, 60-73. doi: https://doi.org/10.1038/s41565-018-0171-6]]> 2018-07-26 01:12:51 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271143412 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271146067 https://www.nature.com/articles/s41565-018-0171-6.epdf?no_publisher_access=1&r3_referer=nature]]> 2018-07-26 01:32:43 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271146067 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271147384 2018-07-26 01:44:03 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271147384 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240330 Physical binding in an acidic environment decreases protein congestion and improves binding capability (Tonigold et al., 2018).

Previously used complex chemical processes have been simplified with the discovery of acidic environment antibody coupling (Tonigold et al., 2018).

The improved nanoparticles increase delivery to target tissue (Tonigold et al., 2018).

Proven to be twice as efficient as chemical bonding in a test tube (Tonigold et al., 2018).

Improves efficiency and applicability of therapy methods (Tonigold et al., 2018).]]> 2018-07-27 00:00:46 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240330 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240347 Without physical binding protein congestion impairs binding sites (Tonigold et al., 2018).

Chemically coupled antibodies almost completely lose their efficacy (Tonigold et al., 2018).

Standard method of binding antibodies using complex chemical processes can degrade and destroy antibodies (Tonigold et al., 2018).

Chemically coupling antibodies is a tedious process and takes longer to complete (Tonigold et al., 2018).

Older methods were unstable when introduced into the blood (Tonigold et al., 2018).]]> 2018-07-27 00:01:04 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240347 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240436 By physically binding antigens in an acidic environment, the nanoparticles are more effective at reaching target tissue.  This method decreases protein congestion and improves binding capability.  The process of physical binding is less time consuming and an easier process than chemical coupling.  This new technique has shown to be twice as efficient as previous methods.  Tonigold et al. (2018) reported, "Once the nanocarrier is exposed to biological fluid such as plasma, however, its surface is inevitably covered with various biomolecules forming the protein corona, which masks the targeting ability of the nanoparticle" (p. 60).  I feel this method should be adopted by our facility to improve patient outcomes by enhancing tissue delivery.  Tonigold et al. (2018) reported, "We conclude that pre-adsorption is potentially a versatile, efficient and rapid method of attaching targeting moieties to the surface of nanocarriers (p. 60).]]> 2018-07-27 00:02:28 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240436 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240465 The following team members were selected after careful evaluation of the critical elements needed for completion of this project.  

Rachel

Restorative - People strong in the Restorative theme are adept at dealing with problems. They are good at figuring out what is wrong and resolving it.  I chose Rachel because she is a problem solver, troubleshooter, and finds improvements and solutions that will be needed during nanotechnology integration. 

Louis 

Learner - People strong in the Learner theme have a great desire to learn and want to continuously improve. In particular, the process of learning, rather than the outcome, excites them.  Louis was added to the team because he is always learning, catches on quickly, and is interested in many things.  He will likely give valuable insight from a different perspective. 

Randall

Responsibility - People strong in the Responsibility theme take psychological ownership of what they say they will do. They are committed to stable values such as honesty and loyalty.  I chose Randall  because he is committed, accountable, independent, trusted, and conscientious.  He will be a dependable source during implementation.

Chelsea

Command - People strong in the Command theme have presence. They can take control of a situation and make decisions.  I selected Chelsea  because she is charismatic, direct, driven, inspirational, easy to follow, clear, and concise.  She will provide positive energy and influence among group members.

Carter 

Communication -  People strong in the Communication theme generally find it easy to put their thoughts into words. They are good conversationalists and presenters.  Carter was added to the team because of his great presence, he is easy to talk to, is an energizer, entertaining, and charismatic.  Communication is crucial during any major project.]]> 2018-07-27 00:02:53 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271240465 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271250820 2018-07-27 01:53:20 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271250820 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271259209 2018-07-27 03:29:18 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271259209 williamerichuff https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271259539 2018-07-27 03:33:15 UTC https://padlet.com/williamerichuff/gyro7ak7f3zk/wish/271259539