Blog Post - Wednesday by Mark Jones https://padlet.com/rmjones10/gy4126npz34cra7k en-us 2021-04-05 16:12:30 UTC 2021-04-21 07:10:27 UTC hello@padlet.com Super cool and relevant blog! I did not know that much about depressive disorders, so to see how a mutation in a gene can cause depressive disorders is really interesting. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1393677854 -Christina]]> 2021-04-07 23:45:25 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1393677854 LOVE the bio-render figure...I couldn't figure out how to use it so I'm lowkey jealous of you guys haha https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1393680815 -Chrsitina]]> 2021-04-07 23:47:16 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1393680815 I also agree with the ambiguity behind the bioethical principle of non-maleficence...even though they consent it seems unethical to expose these people to stressors because it can cause long-term effects that the people did not agree to. Human testing is finnicky and complicated, but I guess it can be okay??? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1393682679 -Christina]]> 2021-04-07 23:48:27 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1393682679 What an interesting topic to write about! I found it fascinating that through this research, they were able to observe that the presence of the oncogenic driver mutations and targeted therapy benefitted both populations (smoking and non-smoking). What exactly did they use for the targeted therapy? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1394703692 - Hailee]]> 2021-04-08 07:08:07 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1394703692 I LOVED your spider web analogy that worked to tie the whole paper together in a very concise way! Your tone of writing made everything very accessible. Great work! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1397295107 -Karen]]> 2021-04-08 18:46:30 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1397295107 (Love the title first off...) Your topic is super relevant and the writeup is really thorough! Amazing work on the Biorender figure visual as well! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1397305308 -Karen]]> 2021-04-08 18:49:08 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1397305308 The organization of your post makes everything super easy to follow which I love! Your section on Mutagene was especially cool and I thought your original figure was really well done and easy to understand :) https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1397328813 -Karen]]> 2021-04-08 18:54:58 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1397328813 The little joke strip included in the beginning was such a great idea and really helps to draws in the reader! The layout was really nice and quite easy to follow. The topic was pretty interesting and makes me wonder as to what would their next steps/continuation of research be in reference to this area of research. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1398693876 -Hailee]]> 2021-04-09 05:09:25 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1398693876 I really liked the bioethical questions you asked. I liked that you looked into the website for answers as well. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400468845 -Becca

]]> 2021-04-09 15:47:58 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400468845 I really like the idea that inhibiting apoptosis could increase the risk of cancer. How interesting! I liked the way you guys wrote this to be easy to understand. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400506860 -Becca]]> 2021-04-09 15:56:26 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400506860 For starters, the fact that you guys actually made a website for your blog post is super cool! The blog was organized and really helped to guide the reader through the exploration of your topic. You really went into depth on the aspects of bioethics and offered some insightful criticism to the paper. I think you guys brought up a good point/question as to if the patients are getting any benefit. The data provided from the patients is a necessity for the research and if the treatments are overpriced, how exactly are they going to ensure that patients will be benefitted from providing valuable data to the research? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400558688 -Hailee]]> 2021-04-09 16:07:55 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400558688 I agree with Hailee, I was also wondering how this information can be used in the future. Using horizontal gene transfer to study evolution is a very smart strategy. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400621037 2021-04-09 16:22:00 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400621037 You did a really good job of explaining each step and concept so that I could really understand the information. I thought the idea of the PLCE1 gene being upregulated was super interesting! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400701475 -Misha ]]> 2021-04-09 16:41:20 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400701475 Love the whole website, and especially the "major findings and conclusions" section. You really went into depth about cancer and its mutational processes, and I learned a lot! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400741848 -Misha]]> 2021-04-09 16:50:44 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400741848 I really liked your blog-- it was super neat and easy to read and understand! The flow cytometry method from the paper that you explained was particularly interesting for me to learn about! I also like that you chose a unique topic! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400769650 -Misha ]]> 2021-04-09 16:57:29 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1400769650 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1401832148 I liked how you guys talked about Spiders in a non scary way! That analogy made it much easier to understand, and the figure you guys made looks great! 

-Alexa]]> 2021-04-10 00:50:24 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1401832148 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1401838259 I know everyone is saying this, but I am amazed you guys made an actual website! It looks great! Also I agree with your guys idea about how their should be a FAQ that provides more transparency. 

-Alexa]]> 2021-04-10 00:56:43 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1401838259 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1401843940 You guys chose such an interesting topic! It’s crazy how modifications that were treated with the therapy had a benefit in smoking and non-smoking populations. I also think it’s cool how you guys went about making your figure! 

-Alexa]]> 2021-04-10 01:03:08 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1401843940 I really loved your analogy to spiders and also thought your conclusion was awesome! I like how you simplified the overall conclusion and point of the data into something that anyone could understand. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402008327 -Audrey

]]> 2021-04-10 04:22:38 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402008327 I really agree with the previous comments about how DNA is like a spider web. I also liked how you guys talked about the bioethics of the research done. There are a lot of different parts of a research experiment and many people don't think of everything they have to cover. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402036547
- Jonas]]> 2021-04-10 05:08:25 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402036547 I really loved the topic you guys chose! Learning about the genetic mechanisms of the coral reefs was really cool to learn about. How do you guys think this relates to land animals/plants? The comic strip was really fun to read by the way. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402044610 2021-04-10 05:21:41 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402044610 This research experiment was really interesting! Do you think depressed patients who were taking serotonin boosters have the same output of cortisol that the original subject group had? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402048033 2021-04-10 05:28:09 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402048033 I really liked your topic and I think epigenetics is really important to understand in our current changing world. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402105260
-Audrey]]> 2021-04-10 06:56:35 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1402105260 This is super cool, especially since it is one of the first to research this topic. I think the findings of this are incredibly important especially since it is in regards to testing something "frowned upon" by medical professionals like smoking. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1414019005 - Aidan]]> 2021-04-13 21:12:00 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1414019005 I too agree with everything said so far! Your lay out was so clear and organized without being bland. The coral decline, bleaching of coral reefs/ and over all the importance of coral is so overlooked in it's value so I love how you guys emphasized its importance in your blog. I was also wondering about how specifically this effects the animals on land and if there is an association between the two. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1414052932 -Aidan ]]> 2021-04-13 21:26:33 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1414052932 I like your title, definitely creative! the organization of your blog made it very easy to understand, it is clear you guys really understood what you were talking about! You explained all the concepts of this topic well enough that someone without a biology background would defiantly be able to understand. I would like to know more about the bioethics of it! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1414081356 -aidan. ]]> 2021-04-13 21:40:05 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1414081356 Your explanation was very clear and easy to follow, and you did a great job summarizing the results of the paper. I hadn't thought about genetic connections to aggression before! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1417275541 -Mariah]]> 2021-04-14 16:19:28 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1417275541 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1417307300 Interesting topic! It makes sense to look for those genetic modifications in both smoking and nonsmoking patients. I wonder, how does this fit into the bioethical concerns around precision medicine?
-Mariah]]> 2021-04-14 16:25:29 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1417307300 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1417371402 I found the discussion of context dependent mutational models interesting, and I like your figure - it's so cute!
-Mariah]]> 2021-04-14 16:37:52 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1417371402 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427475122 Wow I love the website! Other than that, I think that the figure you chose from the paper was a good one. I really love seeing different ways to present data. I also really liked your original figure. It is really well done because we talked about gene alignments in class and it was cool to see it in a real life application.
- Julie Mei]]> 2021-04-17 00:04:48 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427475122 This was such an interesting topic! Finding genetic markers that may predispose someone to a depressive disorder and impact their treatment is something that seems new but likely it would be beneficial to keep studying in the future. In the paper, were they any indications of where this research was going in the future? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427483418 - Julie Mei]]> 2021-04-17 00:12:47 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427483418 I, like everyone else, really liked the comic strip haha. I think that understanding the purpose and functions of endosymbiotic relationships in the ocean is really interesting because as the ocean ecosystem is more and more affected by climate change, it will be interesting to have record of the importance of many of the seemingly small parts of this biome. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427487591 - Julie Mei]]> 2021-04-17 00:16:31 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427487591 I found this article really information through the direct biological impacts, methylation, that depression can have on a person. As well, I thought the connection between methylation being predictors for symptom improvement. My question is the same as Julie Mei's but where do you think this research will lead us in the future? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427492362 -Audrey]]> 2021-04-17 00:20:50 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1427492362 I found it really interesting how aggression could be an inherited feature along certain species. Could there be genetic or epigenetic causes of aggressive traits being passed down within a species? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1431165273 -Max

]]> 2021-04-19 02:31:24 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1431165273 I have lots of friends who smoke, and have family members who have died from lung cancer likely caused by smoking, so it's nice to see that these new therapies have effects in both smokers and non-smokers. I guess it's a little off topic but do you think that in the future we will see studies like this but for vaping instead of smoking? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1431181471 -Max]]> 2021-04-19 02:37:54 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1431181471 Wow! Kind of like the squid paper we read. I find its interesting how symbiosis can have a biochemical explication. Could there be some snRNA interactions happening with these reefs and the organisms with which they are in symbiosis.-Max https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1431216615 2021-04-19 02:52:23 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1431216615 This was really interesting! I hadn't thought about the genetics underlying aggressive behavior before. I also found the explanation of the evolutionary benefit of aggressive behavior really cool. Did they say in the intro or conclusion of the paper if they've looked at a similar phenotype in any other species? normamorella https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1433425280 -Norma

]]> 2021-04-19 14:48:35 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1433425280 This was a really neat article! It was interesting to read about the connection between methylation and depression. And I wonder how researchers will approach the problem you mentioned at the end of your post about those who are depressed without genetic differences. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435136516 -Sharon]]> 2021-04-19 20:33:44 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435136516 I was surprised to read about the ties between aggression and genetics. Your blog post explained the study really well and made it easy for me as a reader to understand the big takeaways of this study. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435221672 -sharon]]> 2021-04-19 21:04:11 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435221672 I enjoyed that the study included both smoking and non-smoking patients. Many of my family members of mine are smokers, so it was quite interesting to read about this. How will researchers expand this therapy and will we be seeing more of it? https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435228230 -sharon]]> 2021-04-19 21:06:49 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435228230 I LOVE THIS TOPIC!! Super interesting take on what we have learned since this is more how genes affect certain behaviors. I love the in-depth explanation of the results and the bio-render figure! Very well done and organized. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435581770 -Christina]]> 2021-04-20 00:02:27 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435581770 What a quirky title hehe. ANYWAYS your bio-render figure is so sophisticated and impressive! I love the idea of epigenetics it was something that got me interested in genetics and hopefully we talk about it more. https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435589950 -Christina]]> 2021-04-20 00:06:11 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1435589950 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441028594 How do you guys think other mental health disorders affect the amount of cortisol that is released? 

-Jonas]]> 2021-04-21 04:46:05 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441028594 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441031816 Epigenetics is a really cool topic!!  I honestly had no idea what it was and reading your blog post help me get a better grasp of it.  
-Jonas]]> 2021-04-21 04:47:48 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441031816 https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441035370 This topic is super cool!  The link between aggression and genetics makes me think of the nature vs nurture idea.  Do you think that aggression is more on the nature or nurture side? 

-Jonas]]> 2021-04-21 04:49:49 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441035370 I really liked the explanation of immunoflorescece with Triton-X 100 and the relationships between the target protein and antibody and between the antibodies! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441044712 2021-04-21 04:55:04 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441044712 Wow! I loved the comparison between DNA and a spiderweb and the endless complexity found when they are examined closely!! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441050775 2021-04-21 04:58:25 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441050775 I really liked the term "evolution of cancer." in a way, observing cancer is observing evolution in a rapid and uncontrollable matter. The website was awesome!!! https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441076692 2021-04-21 05:10:23 UTC https://padlet.com/rmjones10/gy4126npz34cra7k/wish/1441076692