1. What determines translational success/failure? by Rafael Frias https://padlet.com/rafribe/gayy76dhvlbpxe4r en-us 2020-05-05 08:45:13 UTC 2021-09-09 09:16:40 UTC hello@padlet.com use best available animal model- is it good enough to answer the question https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727523054 2021-09-09 09:06:22 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727523054 Good experimental structure https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727524185 2021-09-09 09:07:02 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727524185 systematic review and carefully check previous studies https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727525680 2021-09-09 09:07:56 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727525680 perform meta-analysis of the question https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727527224 2021-09-09 09:08:52 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727527224 select the most suitable animal model https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727528314 2021-09-09 09:09:33 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727528314 experimental design https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727529237 2021-09-09 09:10:05 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727529237 Internal (study design) and external (evidence to other species) validity - in order to be able to translate it to human https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727531022 2021-09-09 09:10:45 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727531022 Yes change is needed - not everything can be studied in humans so animal models will be needed; alternative methods are also needed (e.g. organoids) BUT also a better research needs to be done prior to the experiments https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727537692 2021-09-09 09:14:39 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727537692 conducting systematic review https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727538835 2021-09-09 09:15:22 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727538835 carefully design the protocol and experiment https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727539399 2021-09-09 09:15:43 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727539399 carefully choose the animal model and consider sex, age, weight... https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727540856 2021-09-09 09:16:33 UTC https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727540856 https://padlet.com/rafribe/gayy76dhvlbpxe4r/wish/1727541108 Rely more on non-animal models to get some insights that can improve the design of the animal experiment

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