Hemolytic Disease of the Fetus and Newborn - Graves' Disease by Grace Drinane https://padlet.com/gdrin4974/g64n63lqc1sod4px Grace Drinane, Roxana Diaz, Julia Krause, Chloe Babbs en-us 2022-10-03 18:27:09 UTC 2022-10-06 13:16:32 UTC hello@padlet.com Hemolytic Disease of the Fetus and Newborn gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324368784 2022-10-03 18:31:56 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324368784 Overview of the Condition gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324371856 2022-10-03 18:33:25 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324371856 Risk Factors gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324376312 2022-10-03 18:34:46 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324376312 Group 2 gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324379775 Grace, Roxana, Julia, Chloe]]> 2022-10-03 18:36:45 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324379775 Cellular Level gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324398981 HDFN occurs if the mother has antibodies against erythrocytes, if IgG binds to fetal erythrocytes and causes widespread anti-body mediated hemolysis or splenic removal, and if antibodies (usually IgG) crosses the placenta and enters fetal blood (McCance & Huether, 2019).]]> 2022-10-03 18:48:03 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324398981 Tissue/Organ Level gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324400629 Tissue/Organ Level Pathophysiology
Hemolysis occurs when the mother's antibodies attack babies red blood cells. When this breakdown occurs, excess bilirubin forms, and it is hard for babies to get rid of bilirubin. Hyperbilirubinemia is when bilirubin builds up in the blood, tissues, and fluids. The bone marrow, liver, and spleen increase in size when immature red blood cells are produced. When the baby's organs cannot handle the anemia, they can go into heart failure and have fluid buildup in tissues/organs (Standord Medicine, 2021). ]]> 2022-10-03 18:49:04 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324400629 Boston Children's Hospital gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324401284 2022-10-03 18:49:31 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324401284 Therapeutic Management gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324402019 Expected Therapeutic Management 
(Think Drug Classes)]]> 2022-10-03 18:49:56 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324402019 Recap of Website gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324435247 2022-10-03 19:12:02 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324435247 Overview rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324822219 This is a disorder that causes a baby's RBC to break down quickly.  This occurs when the antigens on fetal erythrocytes differ from the antigens on maternal erythrocytes. Most cases of HDFN are caused by ABO incompatibility, and only one in three cases is caused by Rh incompatibility (McCance & Huether, 2019).]]> 2022-10-04 01:51:19 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324822219 Clinical Manifestations rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324833623 -Mild HDFN: Slightly pale, slight enlargement of the liver and spleen, neonatal jaundice 
-Pallor, splenomegaly, and hepatomegaly indicate severe anemia--> CV failure and shock 
-Kernicterus--> cerebral damage --> death 
-Significant developmental delay, cerebral palsy, high-frequency deafness 
(McCance & Huether, 2019)

]]> 2022-10-04 02:01:45 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324833623 Treatments rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324895330
Immunoprophylaxis: If you're Rh negative and have not been sensitized, you'll get a medicine called Rh immunoglobulin (RhoGAM). This medicine can stop your antibodies from reacting to your baby's Rh positive cells (Medlineplus, 2021). 
Phototherapy:  Converts bilirubin into a form that is easier for the baby's body to get rid of (Medlineplus, 2021). 
Intrauterine blood transfusions 

]]> 2022-10-04 02:55:14 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2324895330 Risk Factors gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326183130 Rh negative mother conceives with an Rh positive father

ABO incompatability

More likely in the second child (Rh sensitization in mother)

(Boston Children's Hospital, 2022)]]> 2022-10-04 17:32:24 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326183130 gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326248500 2022-10-04 18:08:33 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326248500 csbabbs https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326258579 2022-10-04 18:14:12 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326258579 Cellular Level gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326261910 2022-10-04 18:16:13 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326261910 rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326265149 2022-10-04 18:18:08 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326265149 References rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326276207 A.D.A.M. (2021). Rh incompatibility [Photograph]. http://thnm.adam.com/content.aspx?productid=117&pid=1&gid=001600

Alila Medical Media. (2019). Hemolytic Disease of the Newborn, Animation [Video]. Youtube. https://www.youtube.com/watch?v=4hCzGhQPrzk

Boston Children's Hospital. (2022). Hemolytic disease. https://www.childrenshospital.org/conditions/hemolytic-disease

McCance, K. L., & Huether, S. E. (2019). Pathophysiology: The biologic basis for disease in adults and children (8th ed.). Mosby Elsevier.

MedlinePlus. (2021). Hemolytic disease of the newborn. National Library of Medicine. https://medlineplus.gov/ency/article/001298.htm 

Stanford Medicine Children's Health. (2021). Hemolytic disease of the newborn. https://www.stanfordchildrens.org/en/topic/default?id=hemolytic-disease-of-the-newborn-90-P02368 


]]> 2022-10-04 18:23:50 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326276207 gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326296918 A.D.A.M. (2022). photograph. ]]> 2022-10-04 18:36:25 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326296918 gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326316668 McCance. (2019) photograph.]]> 2022-10-04 18:48:09 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326316668 Tissue/Organ Pathophysiology gdrin4974 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326320330 2022-10-04 18:50:22 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2326320330 rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328441206 2022-10-06 00:23:01 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328441206 rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328450265 (A.D.A.M., 2021) ]]> 2022-10-06 00:30:51 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328450265 rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328456415 2022-10-06 00:36:00 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328456415 rdiaz6205 https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328458925 (A.D.A.M., 2021) ]]> 2022-10-06 00:38:19 UTC https://padlet.com/gdrin4974/g64n63lqc1sod4px/wish/2328458925