https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03 en-us 2023-02-19 03:09:04 UTC 2025-10-20 21:09:34 UTC hello@padlet.com aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487367658 Trigger Part A Ryan, a 8-year-old boy presented with history of fever for 3 weeks associated with spontaneous gum bleeding. On examination, he was pale and febrile. Multiple bruises were noted over the upper and lower limbs. There were generalized lymph nodes palpable. The liver was palpable 3 cm below right costal margin and spleen size of 4 cm below left costal margin. ]]> 2023-02-19 03:10:00 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487367658 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487369118 Ryan
8-year old boy

]]> 2023-02-19 03:16:10 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487369118 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487369337 Fever of 3 weeks
spontaneous gum bleeding]]> 2023-02-19 03:17:10 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487369337 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487369434 Infection :
- viral infection (EBV, HIV, acute viral hepatitis, cytomegalovirus (CMV))
--> prolonged fever & splenomegaly

Gum bleeding:
Thrombocytopenia (lack of platelet)
Leukemia (hematological malignancy)
Lymphoma - can be found in children

*Iron Deficiency Anaemia o


]]> 2023-02-19 03:17:33 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487369434 fatihaainaumaira https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487370590 - thrombocytopenia
- trauma (brushing too hard)
- vitamin K deficiency 
- infection
- leukemia]]> 2023-02-19 03:22:24 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487370590 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487372632 other hx to elicit :
respiratory distress
chest pain
cough
SOB
lower respiratory tract
sore throat
dysuria
bloody urine - hemeturia (glomerularnephritis)
vaccination - normally spontaneous onset and not prolonged (in this case is not parallel since pt is having hepatomegaly & spleenomegaly)


Must determine source of fever :
1. Upper or Lower respiratory tract
2. Acute Rhemautic Disease
3. UTI

]]> 2023-02-19 03:30:08 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487372632 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487373166 - indicate anaemia
- low Hb]]> 2023-02-19 03:32:25 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487373166 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487373696 - low platelet
- spontaneous bleed

Bruises : mucocutaneous bleed
- leaking of small capillaries]]> 2023-02-19 03:35:00 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487373696 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487374371 1. Lymph nodes enlarged
- increase proliferation WBC
- fever infection
- infiltration of blast cells

2. Spleenomegaly
(same)
3. Hepatomegaly 
(same)

]]> 2023-02-19 03:37:37 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487374371 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487374722 2023-02-19 03:39:01 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487374722 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487374835 2023-02-19 03:39:39 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487374835 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487375279 1. TWBC : high -> leukocytosis

2. Hb : low -> anaemia

3. Platelet : low -> thrombocytopenia]]> 2023-02-19 03:41:45 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487375279 aliaqistinahidyatul https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487376395 1. pathogenesis of acute leukemia
2. Interpret lab investigation

additional investigation to confirm diagnosis :
- bone marrow biopsy
- bone marrow aspirin
- flow cytometry

3. Types of acute leukemia :
- acute lymphoblastic leukemia (ALL)
- acute myeloid leukemia

4. Pathophysiology of signs and symptoms
- symptoms resulting from bone marrow failure or organ infiltration with leukemic cells

5. MERCI 

6. Treatment : 
- chemotherapy - eradicate blast cell
- blood product (pack cell and platelet transfusion)
- stem cell transplant

7. Differential diagnosis
- at least 5

8. Other signs and symptoms to be elicited of acute leukemia
- cardiac murmur

# each person has not more than 10 minutes
# 5 min - QnA

]]> 2023-02-19 03:47:30 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487376395 imanicebear https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487379732 Blast cell 
- Scanty to moderate cytoplasm 
- No granules
- No nucleoli in nucleus]]> 2023-02-19 04:02:20 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487379732 imanicebear https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487379846 DC : Differential count 
- Neutropenia (low neutrophil)
- divide until blast stage and arrest : mature cell suppressed
- lask of functional WBC -> fever 
- metabolic changes -> fever]]> 2023-02-19 04:02:58 UTC https://padlet.com/aliaqistinahidyatul/fwqthq4diz2dfg03/wish/2487379846