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      <title>Honors K357 Assignment 4: Clostridioides difficile by </title>
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      <description>Made with a side of bacteria</description>
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      <pubDate>2025-04-16 15:21:19 UTC</pubDate>
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         <title>CDC Page</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412621539</link>
         <description><![CDATA[]]></description>
         <enclosure url="https://www.cdc.gov/c-diff/about/index.html#:~:text=Most%20cases%20of%20C.%20diff,risk%20for%20developing%20C.%20diff." />
         <pubDate>2025-04-16 15:22:09 UTC</pubDate>
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         <title>What is Clostridioides difficile?</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412622126</link>
         <description><![CDATA[<p><strong><em>Clostridioides</em> <em>Difficile, </em></strong>also known as <strong><em>C. diff</em></strong> or <strong><em>Clostridium diffiicle, </em></strong>is a gram-positive, spore-forming, rod shaped bacterium that causes diarrhea and inflammation within the colon. It spreads from person to person through <strong>feces</strong>. Most of the cases are of individuals that have been taking antibiotics or recently finished taken them. </p><p><br/></p><p>Individuals are <strong>10 times</strong> more liked to get C. diff during the time they are taking antibiotics or the three months after. C. Diff is also commonly seen in hospital or nursing home setting but is <strong>not limited</strong> to these areas. Those with weakened immune systems, are older than 65, or have previous exposure are also at <strong>higher</strong> risk.</p>]]></description>
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         <pubDate>2025-04-16 15:22:42 UTC</pubDate>
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         <title>What is the caustive agent?</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412622350</link>
         <description><![CDATA[<p><a rel="noopener noreferrer nofollow" href="https://www.consultant360.com/article/clostridium-difficile-infection-what-you-need-know">Clostridium difficile bacilli </a></p>]]></description>
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         <pubDate>2025-04-16 15:22:54 UTC</pubDate>
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         <title>Symptoms</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412622740</link>
         <description><![CDATA[<p>Some of the common <a rel="noopener noreferrer nofollow" href="https://www.cdc.gov/c-diff/about/index.html#:~:text=Most%20cases%20of%20C.%20diff,risk%20for%20developing%20C.%20diff.">symptoms</a> that are connected with an infection of Clostridium difficile are <strong>watery diarrhea</strong>, <strong>fever</strong>, <strong>loss of appetite</strong>, <strong>nausea</strong>, and <strong>abdominal pain</strong>.</p>]]></description>
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         <pubDate>2025-04-16 15:23:16 UTC</pubDate>
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      <item>
         <title>Emerging Threats or Success</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412623258</link>
         <description><![CDATA[<p>In a recently article, a new treatment, <strong>SCUT1-2,</strong> is a hybrid of the bile acid metronidazole. This new treatment is being tested to allows for the inhibition and kiiling of <em>c. diff</em> in its vegetative form and spore germination. As well as preventing the growth of <em>c. diff </em>cells, the treatment also has less an effect on the gut microbiota.</p>]]></description>
         <enclosure url="https://pubmed.ncbi.nlm.nih.gov/40233427/b" />
         <pubDate>2025-04-16 15:23:49 UTC</pubDate>
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         <title>Prevention and Treatment</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412623469</link>
         <description><![CDATA[<ol><li><p>Implementing infection control measures</p></li><li><p>Discontinue causative antibiotics</p></li><li><p>Administer appropriate medications bases on guidelines</p></li><li><p>Screen patients with diarrhea for <strong><em>c. diff</em></strong></p></li><li><p>Stool transplantation (fecal bacteriotherapy)</p></li><li><p>Isolation and hygiene</p></li><li><p>Probiotics</p><p><br/></p><p><a rel="noopener noreferrer nofollow" href="https://www.ncbi.nlm.nih.gov/books/NBK431054/">More info</a></p></li></ol>]]></description>
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         <pubDate>2025-04-16 15:24:03 UTC</pubDate>
         <guid>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412623469</guid>
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         <title>Diagnosis</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412623778</link>
         <description><![CDATA[<p>Laboratory tests can be done that can detect <strong>causative organisms </strong>(bacterial culture, antigen detection), or <strong>toxins</strong> (PCR data) with one's stool.</p><p><br/></p><p><strong><mark>Example of lab tests:</mark></strong></p><ol><li><p><strong>Toxin detection EIA</strong>: relatively simple and less espensive than PCR</p></li><li><p><strong>Molecular tests</strong>: detects the gene encoding toxin B that are highly sensitive (preferred test)</p></li><li><p><strong>Tissue cytotoxin assay</strong>: Test is more sensitve than EIAs, slow turnover rate.</p></li><li><p><strong>Stool culture</strong></p></li><li><p><strong>Antigen detection</strong></p></li></ol><p><br/></p><p>It can also be a suspected diagnosis if an individual presents with diarrhea and also received antibiotic in the last 2 months.</p><p><br/></p><p>(<a rel="noopener noreferrer nofollow" href="https://www.consultant360.com/article/clostridium-difficile-infection-what-you-need-know">more here</a>)</p><p><br/></p><p><br/></p>]]></description>
         <enclosure url="" />
         <pubDate>2025-04-16 15:24:22 UTC</pubDate>
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         <title>Infographic!</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412623969</link>
         <description><![CDATA[<p><a rel="noopener noreferrer nofollow" href="https://health.hawaii.gov/docd/disease_listing/clostridium-difficile-infections-c-diff-cdi/!">Source</a></p>]]></description>
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         <pubDate>2025-04-16 15:24:33 UTC</pubDate>
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         <title>Scientist &amp; University</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412624345</link>
         <description><![CDATA[<p>An inflammatory bowel disease (IBD) physician at Massachusetts General Hospital, and instructor at Harvard Medical School. She also specializes in research within ulcerative colitis, Crohn's disease and microscopic colitis.</p>]]></description>
         <enclosure url="https://researchers.mgh.harvard.edu/profile/13678604/Kristin-Burke" />
         <pubDate>2025-04-16 15:24:54 UTC</pubDate>
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         <title>Learn More...</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412624450</link>
         <description><![CDATA[]]></description>
         <enclosure url="https://www.youtube.com/watch?v=dv9NxHnLmTs" />
         <pubDate>2025-04-16 15:25:01 UTC</pubDate>
         <guid>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412624450</guid>
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         <title>Complications</title>
         <author>athahn</author>
         <link>https://padlet.com/athahn/ft1c6b46ascnhuff/wish/3412808461</link>
         <description><![CDATA[<p>Complications that relate to C. Diff include:</p><p><br/></p><p><strong><mark>Common Complications</mark></strong></p><ul><li><p>Dehydration</p></li><li><p>Colitis (Inflammation of colon)</p></li></ul><p><strong><mark>Rare Complication</mark></strong></p><ul><li><p>Serious Intestinal conditions, like megacolon</p></li><li><p>Sepsis</p></li><li><p>Death</p></li></ul><p><br/></p><p><br/></p>]]></description>
         <enclosure url="" />
         <pubDate>2025-04-16 18:26:09 UTC</pubDate>
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