https://padlet.com/vaz17/fry2shwjgtoc Vanessa Zermeno en-us 2018-04-04 15:34:44 UTC 2023-02-11 14:27:42 UTC hello@padlet.com https://padlet-assets.s3.amazonaws.com/icons/Doubleheart.png vaz17 https://padlet.com/vaz17/fry2shwjgtoc/wish/248547211 ^{The disease is caused by a mutation in a gene that is located in chromosome 4, in the region of the first exon of the gene.  This gene is found in every human, it has the CAG repeat sequence. the gene's normal function has yet to be discovered .  When exposed to the disease the gene will contain an abnormally large number of the CAG repeats, the large the number greater the chance the disease will develop earlier in a carrier's life.} ]]> 2018-04-04 15:36:03 UTC https://padlet.com/vaz17/fry2shwjgtoc/wish/248547211 vaz17 https://padlet.com/vaz17/fry2shwjgtoc/wish/248547374

^{Symptoms of Huntington's usually begin to develop and show between the ages of 30-50; in some cases they can begin to appear as early as the age of 2 or as late as the age of 80.} 

^{The symptom that is typically shown as sign of Huntington's would be the uncontrollable movement of the legs, arms, face, head, and the upper body.} 

^{With the decline in motor skills there is also the "decline of thinking and reasoning skills, including memory, concentration, judgment and ability to plan and organize (alz.org).} 

^{Another symptom is the alterations in moods, especially depression, anxiety, anger and irritability. As well there is the development of obsessive-compulsive behavior, which leads the person to the same question or activity they were doing over and over again.}

]]> 2018-04-04 15:36:23 UTC https://padlet.com/vaz17/fry2shwjgtoc/wish/248547374 vaz17 https://padlet.com/vaz17/fry2shwjgtoc/wish/248547475 ^{Currently there is no cure for the disease. there is no way to slow down or stop the brain changes it brings. However, there is treatment that is focused on managing the symptoms it brings. There is strategies that a group of international experts recommend doing when exposed to the most troubling of the symptoms:
Chorea (involuntary movements): Some experts believe beginning treatment with an atypical antipsychotic drug, such as olanzapine, is best. Others start with another type of drug recently approved by the U.S. Food and Drug Administration (FDA) specifically for Huntington’s, called tetrabenazine.
Irritability: For severe anger and threatening behavior, experts agree that an atypical antipsychotic drug is the preferred approach. For less severe, nonthreatening irritability, experts recommend first trying a selective serotonin reuptake inhibitor (SSRI), which is a type of antidepressants.
Obsessive-compulsive thoughts and actions: Experts also recommend SSRIs as the standard treatment for these symptoms}.]]> 2018-04-04 15:36:37 UTC https://padlet.com/vaz17/fry2shwjgtoc/wish/248547475 vaz17 https://padlet.com/vaz17/fry2shwjgtoc/wish/248547531 ^{Huntington's is the most commonly inherited neurodegenerative disease dominantly inherited. It is characterized by the excess of motor movements and neuropsychological deficits (Harper 2002; Lund 1860). The fact that the disease is dominant means that if anyone inherits it from a parent will eventually develop the disease themselves. If the disease is passed down from the father to child, not the mother, the disease will begin to show in earlier stages of life; this is know as anticipation. If the parent has the gene but does not pass it down to the chid, the gene will not be passed down to their offspring.}]]> 2018-04-04 15:36:44 UTC https://padlet.com/vaz17/fry2shwjgtoc/wish/248547531 vaz17 https://padlet.com/vaz17/fry2shwjgtoc/wish/248547709 ^{Back in 1872 George Huntington, a young physician, published the first description of a disease that would one day come to bare his name. Huntington's is a progressive brain disorder which is caused by a "single defective gene of Chromosome 4", one of the 23 human chromosomes that a person's whole genetic code is on. This is a fatal genetic disorder that begins to progressively breakdown the nerve cells in the brain, it will deteriote a person's ability to do physical movements as well slow down their mental abilities during their most prime years.} ]]> 2018-04-04 15:37:07 UTC https://padlet.com/vaz17/fry2shwjgtoc/wish/248547709 vaz17 https://padlet.com/vaz17/fry2shwjgtoc/wish/253243755 2018-04-19 01:00:20 UTC https://padlet.com/vaz17/fry2shwjgtoc/wish/253243755 vaz17 https://padlet.com/vaz17/fry2shwjgtoc/wish/257465827 ^{JHD is the form of HD that affects children and teenagers. This is caused by a mutation in the huntingtin gene, this is what we call "CAG repeat expansion." JHD involves a more rapid progression rate than the adult onset. The earlier it happens the faster the disease progresses. JHD death occurs within 10 years compared to the 10-25 years the adults have.}]]> 2018-05-02 22:41:11 UTC https://padlet.com/vaz17/fry2shwjgtoc/wish/257465827