PHR1122 Help Us Help You (Topic 3) by Ong Yong Sze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn Please feel free to comment, respond, and support your peers (and yourself!) as we learn together. Use this space to explore ideas, ask questions, and clarify concepts. We will also check in here to help confirm what’s on the right track and gently correct anything that might need a little tweak. Let’s make learning active and collaborative! en-us 2025-08-08 04:51:19 UTC 2025-09-02 09:30:10 UTC hello@padlet.com https://padlet.net/icons/8.0/png/1f64b.png Question 1: Noradrenaline, released from sympathetic nerves acts at presynaptic α2-adrenoceptors. These receptors help regulate neurotransmitter release through......? ongyongsze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538342570 2025-08-08 05:04:22 UTC https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538342570 Question 2: Angiotensin II is a powerful peptide vasoconstrictor. How is it most likely to work? ongyongsze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538342716 2025-08-08 05:04:41 UTC https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538342716 Question 3: A G-protein heterotrimeric complex becomes “activated” upon binding to an agonist-bound G-protein coupled receptor. This activation requires....? ongyongsze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538342856 2025-08-08 05:05:00 UTC https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538342856 Question 4: Here's a graph showing changes in intracellular cAMP in response to an agonist (XYZ). What do you think the XYZ curve is most likely to look like in the presence of a competitive reversible antagonist? ongyongsze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538343042 2025-08-08 05:05:25 UTC https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538343042 Question 5: Here's a graph showing changes in intracellular cAMP in response to a partial agonist (XYZ). What do you think the XYZ curve is most likely to look like in the presence of an irreversible inhibitor of phosphodiesterase? ongyongsze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538343190 2025-08-08 05:05:44 UTC https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538343190 Question 6: Here's a graph showing a smooth muscle contraction in response to an agonist (XYZ). We assume that there is a resting level of adenylate cyclase activity. What do you think the XYZ curve is most likely to look like in the presence of an irreversible inhibitor of phosphodiesterase? ongyongsze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538343411 2025-08-08 05:06:04 UTC https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3538343411 Question 4, 5 and 6 show a graph with multiple curve options to choose from (so you'll pick the most likely from a series of three to five curves). I have not included the graphs because I want you to draw what you think the right answer might be! So start drawing! ongyongsze https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3541276953 2025-08-12 09:41:29 UTC https://padlet.com/monashmalaysia1/f8zakiwiqswcuxxn/wish/3541276953