https://padlet.com/jmacciochi1/f7pdhdr01foh C7121 Immunology 2018 en-us 2018-07-31 09:29:00 UTC 2023-05-08 11:54:36 UTC hello@padlet.com jmacciochi1 https://padlet.com/jmacciochi1/f7pdhdr01foh/wish/271540851 Defective CD8+ T cell response following acute infection without CD4 T cell help]]> 2018-07-31 09:30:04 UTC https://padlet.com/jmacciochi1/f7pdhdr01foh/wish/271540851 jmacciochi1 https://padlet.com/jmacciochi1/f7pdhdr01foh/wish/271540914 What can you conclude from panel A and panel B?

Why did they need an unimmunised control in panel B?

What is Kb/OVA and which cells does it detect?

What is the difference between the left and right graphs in Figure 1C?]]> 2018-07-31 09:31:39 UTC https://padlet.com/jmacciochi1/f7pdhdr01foh/wish/271540914 jmacciochi1 https://padlet.com/jmacciochi1/f7pdhdr01foh/wish/271541021 What would be expected from the data analysis of a Kb/OVA vs. CD44 dot plot?

Do the CD8 T cells develop normally in absence of MHC II? Why?

Do the CD8 T cells function  normally in the  absence of  MHC II? Why?

What type of FC application is shown in the density plots?

Why did they need a 'no peptide' control?

What do you conclude from the plots?

What is the purpose of the experiement in figure 2D?

What can the authors conclude from the experiment in figure 2E?

]]> 2018-07-31 09:34:44 UTC https://padlet.com/jmacciochi1/f7pdhdr01foh/wish/271541021 jmacciochi1 https://padlet.com/jmacciochi1/f7pdhdr01foh/wish/271541160 Memory CD8+ T cells from MHC class II−/− mice show reduced ability to proliferate after transfer into wild-type mice. Explain how they used the Thy1.1-/+ system to investigate this?

What can we conclude about the homeostatic balances of naïve and memory cells?

Are CD4 T cells important to fight bacterial infections?

The authors used a recombinant strain that expressed ovalbumin (rLmOVA) for the infections. Why was this necessary? 

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