3D Organs and a Vascular Network by https://padlet.com/asalyer3/eu9csav390b7 By Ashley Salyer en-us 2019-09-10 14:54:06 UTC 2024-11-15 16:53:53 UTC hello@padlet.com Source Details asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382203737 Harvard University Wyss Institute for Biologically Inspired Engineering and Harvard University and John A. Paulson School of Engineering and Applied Sciences (SEAS) Researchers: Mark A. Skylar- Scott, Sebastien G. M. Uzel, Lucy L. Nam, John H. Ahrens, Ryan L. Truby, Sarita Damaraju and Jennifer A. Lewis 
 

]]> 2019-09-10 14:56:20 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382203737 Date Published asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382204687 September 6, 2019]]> 2019-09-10 14:57:39 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382204687 Summary of Current Innovation asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382204905 Many researchers are working on growing human organs in a lab with 3D printing due to the lack of availability of organs for transplant. There has been much success in 3D printing heart valves and single parts of organs. The new technique that has been created is called Sacrificial Writing into Functional Tissue (SWIFT), which prints vessels within a pre-existing live cell matrix. This innovation is the first that gives these organs viability and function by providing a vascular network for oxygen delivery. This method has created cardiac tissue that beats over a seven-day period. Ultimately, this innovation will lead to engineering a fully functional 3D printed human heart. ]]> 2019-09-10 14:57:59 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382204905 Video about SWIFT Technique asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382205848 This video explains Sacrificial Writing into Functional Tissue (SWIFT). ]]> 2019-09-10 14:59:18 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382205848 Hollow Vascular Channel asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382207594 This is a photo of a hollow vascular channel printed using the SWIFT method.]]> 2019-09-10 15:01:42 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382207594 Mini-Heart Beating asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382208954 This is a mini-heart that kept beating for 7 days based off this new innovation. ]]> 2019-09-10 15:03:17 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382208954 Pros of Innovation asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382209816
1. Advances the field of organ engineering
2. Provides 3D organs with vascular network/effective oxygen delivery
3. Possible solution to lack of organ availability for transplant 
4. Reduces transplant wait time 
5. If patients own stem cells used to create organ this could decrease chances of rejection or even possibly not having to take anti-rejection medications 
]]> 2019-09-10 15:04:29 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382209816 Cons of Innovation asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382211097 1. SWIFT focuses on single vessels rather than entire organs 
2. Cost/ time/ resources
3. Longevity- 7-day period currently 
]]> 2019-09-10 15:06:09 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382211097 Opinion with Rationale asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382211579 I believe this is a fantastic advancement in the world of 3D printing of organs. I have worked as a Cardiacthoracic and Transplant ICU nurse for the past 3 years. I have seen many patients receive heart transplants, I have seen many patients wait for months, and I’ve even seen many die while waiting for transplant. This further innovation in 3D printing provides the vascular network needed for a heart to beat and have blood supply ultimately leading to creation in the future of a completely 3D printed heart that beats and pumps just like a human heart. This could change wait times for transplant, how sick patients are going into transplant, and devices we use to support patients pre-transplant may no longer even be needed if hearts and other organs are readily available because of 3D printing. Because of this advancement many lives will be saved. ]]> 2019-09-10 15:06:45 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382211579 Teams asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382212694 My top 5 strengths are responsibility, discipline, relator, restorative, and belief. Based off my strengths, I have created a team of different strengths so we can all work together to further this innovation into a complete 3D organ. This innovation would not currently be adopted by a facility for use with patients, but could be used by a facility to further advancement in a 3D functional organ. I would choose Faith, Daisy, Ivan, Sheila, and Andrew. 

Faith is futuristic. She is inspired by the future which is important as this advancement is just one step in creating an entirely 3D printed and functional organ. She can inspire the team and researchers to look to the future. 

Daisy is a developer. As a team we will need to work together and with the researchers to develop an entire organ based off this most recent innovation. She recognizes the potential in this advancement and can help improve based off this new technique. 

Ivan has intellection. He will be able to guide the team in intellectual conversations and possibly has new ideas on how to advance this technology. 

Sheila is strategic. She is able to create alternative ways to proceed with the creation of an organ and when faced with challenges will be able to work with the other team members to create a new plan. 

Andrew is an activator. Andrew will make things happen and help continue to progress this innovation into something more. 

Together we will work as a team to create an organ and save lives! 
]]> 2019-09-10 15:08:17 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382212694 References asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382213635 Essop, A., Jackson, B., Vialva, T., Lo, A., & Petch, M. (2019, September 9). Harvard researchers develop SWIFT method to 3D print organ building blocks. Retrieved from https://3dprintingindustry.com/news/harvard-researchers-develop-swift-method-to-3d-print-organ-building-blocks-161358

Hastings, C. (2019, September 9). Sacrificial ink writing technique for 3D printed organs. Retrieved from https://www.medgadget.com/2019/09/sacrificial-ink-writing-technique-for-3d-printed-organs.html

Skylar-Scott, M. A., Uzel, S. G. M., Nam, L. L., Ahrens, J. H., Truby, R. L., Damaraju, S., & Lewis, J. A. (2019). Biomanufacturing of organ-specific tissues with high cellular density and embedded vascular channels. Science Advances, 5(9). doi: 10.1126/sciadv.aaw2459
 

]]> 2019-09-10 15:09:26 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382213635 Research Article asalyer3 https://padlet.com/asalyer3/eu9csav390b7/wish/382235809 2019-09-10 15:40:19 UTC https://padlet.com/asalyer3/eu9csav390b7/wish/382235809