https://padlet.com/msctay/301discussion Discussion Questions en-us 2018-07-03 04:29:02 UTC 2026-02-07 18:24:13 UTC hello@padlet.com msctay https://padlet.com/msctay/301discussion/wish/269225885 Give your answers in this format:
1.

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5.]]> 2018-07-03 04:32:44 UTC https://padlet.com/msctay/301discussion/wish/269225885 https://padlet.com/msctay/301discussion/wish/269228332 1.  alcohol —————————————> acetaldehyde
                   alcohol dehydrogenase

acetaldehyde—————————-> harmless substances 
              acetaldehyde dehydrogenase

2. - 80% of Asians have an overactive alcohol dehydrogenase
- alcohol is broken down faster into acetaldehyde

3. 

4. - build-up of acetaldehyde causes blood vessels to dilate,
- hence causing the face to turn red

5. They will no longer feel the ‘buzz’ that they enjoy.

]]> 2018-07-03 05:14:56 UTC https://padlet.com/msctay/301discussion/wish/269228332 https://padlet.com/msctay/301discussion/wish/269228366 1. alcohol -- alcohol dehydrogenase --> acetaldehyde 
 acetaldehyde -- acetaldehyde dehydrogenase --> harmless substances

2. Most Asians have an inactive variant of the liver enzyme acetaldehyde dehydrogenase (ALDH2) which means that acetaldehyde takes much longer to clear from their blood. The buildup of acetaldehyde thus causes blood vessels to dilate and the face to turn red.

3. Not ideal temperature, as when the temperature is too low enzymes are inactive. Unsuitable pH levels can cause the enzymes to not be able to function at its optimum. Deformed active sites due to denaturing of the enzymes can also prevent the enzyme from functioning properly as without active sites, chemical reactions cannot be carried out.


4. In Asian Flush Syndrome, the blood vessels dilate and blood is pumped to all parts of the body faster. This causes more blood to rush to the face, and cause the face to turn red.

5. The drug, disulfiram blocks the breaking down of alcohol into harmless substances, thus addicted individuals will not be able to feel the buzz of alcohol and will not find it enjoyable, as the buzz is caused by the breakdown of alcohol.]]> 2018-07-03 05:15:32 UTC https://padlet.com/msctay/301discussion/wish/269228366 https://padlet.com/msctay/301discussion/wish/269228450 1. -alcohol is broken down into acetaldehyde by alcohol dehydrogenase
-acetaldehyde is broken down into harmless substances by acetaldehyde dehydrogenase (ALDH2)
2. Asians have inactive variant of liver enzyme ALDH2 so acetaldehyde takes a longer time to break down into harmless substances 
3. genetic inability
4.build-up of acetaldehyde causes blood vessels to dilate & face turns red 
5.there will be build-up of acetaldehyde causing facial blushing , rapid heartbeat , nausea and headaches , which causes them pain , thus will stop drinking]]> 2018-07-03 05:17:01 UTC https://padlet.com/msctay/301discussion/wish/269228450 https://padlet.com/msctay/301discussion/wish/269228452 1. alcohol + alcohol dehydrogenase -> acetaldehyde 
acetaldehyde + acetaldehyde dehydrogenase -> harmless substances (ethanoic acid) 
2. Asians have an overactive alcohol dehydrogenase, they tend to break down alcohol into acetaldehyde faster - up to 100 times faster. As alcohol is broken down faster, there may be little to no alcohol "buzz". Making things worse, most asians have an inactive variant of the liver enzyme ALDH2, which means that acetaldehyde takes much longer to clear from their blood. 
3. The pH and temperature is not optimum, thus it is not suitable for ALDH2.
4. The build-up of acetaldehyde is what causes blood vessels to dilate and the face turns red. 
5. After the alcoholic consumes the drug, the 'buzz' from consuming the alcohol will be absent. ]]> 2018-07-03 05:17:04 UTC https://padlet.com/msctay/301discussion/wish/269228452 https://padlet.com/msctay/301discussion/wish/269228464 En ryn,yu en, yi shan, woon sze, jun lynn
1. Alcohol + alcohol dehydrogenase = acetaldehyde + acetaldehyde dehydrogenase(ALDH2) 
2. Overactive alcohol dehydrogenase,break down alcohol into acetaldehyde faster, inactive ALDH2, takes much longer to clear acetaldehyde.
3. 
4. The build up of acetaldehyde causes blood vessels to dilate and face to turn red.
5. After consumption of this drug, the 'buzz'of alcohol disappears.]]> 2018-07-03 05:17:14 UTC https://padlet.com/msctay/301discussion/wish/269228464 https://padlet.com/msctay/301discussion/wish/269228535 1. alcohol —alcohol dehydrogenase—> acetaldehyde—acetaldehyde dehydrogenase —> harmless substances
2. inactive variant of liver enzyme ALDH2, thus acetaldehyde takes much longer to clear from blood/gets detoxified.
3. -not optimum pH levels
-body temperature is not at optimum
4. buildup of acetaldehyde causing blood vessels to dilate
5. ALDH2 will be unable to break down all the acetaldehyde , causing the alcoholics to still get the symptoms of asian flush syndrome eg. rapid heartbeat, nausea and headaches. since the alcoholics will drink without feeling the happiness they normally feel, but instead feel sick and uncomfortable, they might choose to stop drinking.

another idea is that since the drug takes away the “buzz” that alcoholics enjoy, when they drink after taking the drug, they will not feel “high” or feel happy anymore and will just feel like they are drinking plain water or carbonated drinks. since alcohol is expensive, they will prefer to buy other drinks instead. ]]> 2018-07-03 05:18:07 UTC https://padlet.com/msctay/301discussion/wish/269228535 https://padlet.com/msctay/301discussion/wish/269228649 1. Alcohol ———>acetaldehyde 

2. An inactive variant of the liver enzyme ALDH2

3. Inactive variants ALDH2 are made less functional by having deformed active sites 

4. The buildup of acetaldehyde causes blood vessels to dilate and you’re face to turn red.

5. They would no longer experience the ‘buzz’ that they usually experience and enjoy and so would no longer like to drink.


]]> 2018-07-03 05:19:29 UTC https://padlet.com/msctay/301discussion/wish/269228649 msctay https://padlet.com/msctay/301discussion/wish/269229431 1. Alcohol + alcohol dehydrogenase ---> acetaldehyde

2.When there is a higher concentration of alcohol dehydrogenase, alcohol will be broken down quickly into acetaldehyde. However, low levels of acetaldehyde hydrogenase will prevent acetaldehyde from being broken down quickly, causing the build up of acetaldehyde.

3. The stomach will be damaged by excessive levels of acetalhyde and will not be suitable for ALDH2. More ALDH2 will remain inactive and more acetaldehyde will not be able to broken down into harmless substances.

4. The dilation of blood vessels in the face caused by the build-up of acetaldehyde.

5. They will not feel the 'buzz' that they enjoy and lose interest.]]> 2018-07-03 05:31:10 UTC https://padlet.com/msctay/301discussion/wish/269229431