https://padlet.com/aagouni78/empmjbgjfkiw Made with a bold sensibility en-us 2017-11-16 08:07:44 UTC 2025-12-03 23:20:49 UTC hello@padlet.com https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943469 q1: Cocaine mechanism of toxicity: CNS stimulation and inhibition of catecholamine uptake. Blockade of sodium channels in cardiac cells leading to depression of conduction and contractility. QT prolongation is also a manifestation of cocaine toxicity.
Q3:  With chronic cocaine use, insomnia, weight loss, and paranoid psychosis may occur. A "washed-out" syndrome has been observed in cocaine abusers after a prolonged binge, consisting of profound lethargy and deep sleep that may last for several hours to days, followed by spontaneous recovery.
Q2:
1- CNS system: euphoria, anxiety, psychosis, / seizure/cpma/drug induced stroke/insomnia/ weight-loss
2- CVD toxicity: ventricular tachycardia/fibrillation/ severe HTN/ renal failure
3- death: sudden fatal arrhythmia/ status epilepticus 
4- other: chest pain/ pneumothorax, chest pain/ nasal septal perforation
 ]]> 2019-10-20 08:18:16 UTC https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943469 https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943479 Q5- Diazepam is a good choice for the management of hypertension and tachycardia associated with agitation (caused by cocaine toxicity)
Q6- There is no specific antidote to cocaine
Q7- Beta blockers are needed for tachycardia not responsive to BZD and IV fluids especially if associated with MI. example: Esomolol in combination with vasodilator (such as Phenotalamine) for management of hypertension.

]]> 2019-10-20 08:18:24 UTC https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943479 https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943529 Q4:
 A.   Specific levels: Blood cocaine levels are not routinely availableand do not assist in emergency management. Cocaine and itsmetabolite benzoylecgonine are easily detected in the urine forup to 72 hours after ingestion and provide qualitativeconfirmation of cocaine use.
  B.   Other useful laboratory studies include: electrolytes, glucose,BUN, creatinine, creatine kinase (CK), urinalysis, urinemyoglobin, cardiac troponin, ECG and ECG monitoring, CT headscan (if hemorrhage is suspected), and abdominal radiography (if cocaine-filled condom or packet ingestion is suspected)]]> 2019-10-20 08:19:15 UTC https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943529 https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943810 CNS manifestation: euphoria followed by anxiety, agitation, delirium, psychosis, tremulousness, muscle rigidity and seizures. Can cause respiratory arrest, or coma.
CV toxicity: fatal ventricular tachycardia/ fibrillation, QRS interval prolongation. And severe hypertension which can lead to hemorrhagic stroke or aortic dissection.
Other presentations:
-Chest pain w/o ECG evidence of MI
-Pneumothorax
-Nasal septal perforation]]> 2019-10-20 08:22:49 UTC https://padlet.com/aagouni78/empmjbgjfkiw/wish/399943810 https://padlet.com/aagouni78/empmjbgjfkiw/wish/399944239 Q1: Cocaine causes extreme dilation of the pupils that results in a sensitivity to light, so more light is let through the pupils.
Q2: ECG, electrolytes, urinanalysis, urine myoglobin, cardiac troponin,  creatinine, BUN, CrCl, creatinine kinase,  CT scan, abdominal radiography.
Q3: Esmolol]]> 2019-10-20 08:28:34 UTC https://padlet.com/aagouni78/empmjbgjfkiw/wish/399944239