Anti- malarial Drug development by Mr McGuckin https://padlet.com/cmcguckin_wis1/ed3135zgys79 en-us 2018-01-11 04:16:24 UTC 2018-01-11 07:42:40 UTC hello@padlet.com cmcguckin_wis1 https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220449534 Outline the reasons for development of new anti-malarial drugs.]]> 2018-01-11 04:16:50 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220449534 The already existing drugs are losing effectiveness. This is because the plasmodium parasite that causes malaria is developing resistance to the current anti-malarial drugs. https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220467390 2018-01-11 07:24:49 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220467390 Drug resistance samalbanna https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468069 2018-01-11 07:28:04 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468069 Most common drugs https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468545 The most common antimalarial drugs include and are slowly losing effectiveness.

  • Chloroquine (Aralen)
  • Quinine sulfate (Qualaquin)
  • Hydroxychloroquine (Plaquenil)
  • Mefloquine
  • Combination of atovaquone and proguanil (Malarone)
]]> 2018-01-11 07:30:26 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468545 https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468880 Mutations]]> 2018-01-11 07:32:46 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468880 Malaria parasite is developing resistance towards drugs used to treat the disease. https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468977 2018-01-11 07:33:22 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220468977 https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469161 The current anti-malarial drugs may have tto many side effects.
The side effects are:
www.nevdgp.org.au/info/travel/bots/antimalarial_se.htm

]]> 2018-01-11 07:34:06 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469161 Current treatments appear to be ineffective cmcguckin_wis1 https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469289
Malaria elimination has recently been reinstated as a global health priority but current therapies seem to be insufficient for the task. Elimination efforts require new drug classes that alleviate symptoms, prevent transmission and provide a radical cure. To develop these next generation medicines, public-private partnerships are funding innovative approaches to identify compounds that target multiple parasite species at multiple stages of the parasite lifecycle.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3941073/

]]> 2018-01-11 07:34:50 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469289 The malaria parasites are starting to produce resistance to the current anti-malarial drugs such as Aralen and Qualaquin. By develloping new anti-malarial drugs, it will stop the disease from spreading to more people. https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469401 2018-01-11 07:35:28 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469401 Resistance cmcguckin_wis1 https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469847  Although effective antimalarials are currently available (BOX 1) that could be used in eradication campaigns, there are two major problems. The first is the potential emergence of resistance to artemisinin and its derivatives, which are the most effective drugs available today ]]> 2018-01-11 07:37:42 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220469847 https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220470126 Malaria kills an estimated 660,000 people each year.]]> 2018-01-11 07:39:05 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220470126 Malaria parasites have developed a resistance to drugs that already exist. Also if a certain drug kills off only one Malaria spreading organism, it still leaves other organisms to spread Malaria, though it may be at different rates. https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220470667 2018-01-11 07:41:39 UTC https://padlet.com/cmcguckin_wis1/ed3135zgys79/wish/220470667