Stem Cell Research by Tasneem Bhaiji

Stem cell IVF treatment:

25rp49 — 2023-11-09 08:49:38 UTC

Infertility in women is caused by a variety of diseases such as ovarian failure, polycystic ovary syndrome, endometriosis, and Asherman syndrome.

Stem cell treatment for female infertility creates undifferentiated cells with fewer complications than the traditional procedure. It helps in the creation of oocytes and ovarian cell production, therefore the overall fertility increases heavily.

For patients with reduced ovarian reserve, stem cell therapy has a success rate of 72%.

Problems:

--> It is an expensive procedure that can be seen as immoral by some people since the embryos that are not implanted are then frozen or destroyed, which can be seen as killing a future life.

--> Furthermore selecting embryos and potentially discarding others may not sit well with everybody as it is unfair that some embryos are "denied the chance of life".

Spinal Cord Injury Treatment

2023-11-09 08:49:56 UTC

Stem Cells Therapy for Multiple Sclerosis

2023-11-09 08:51:09 UTC

Stem Cell therapy for epilepsy

2023-11-09 08:54:27 UTC

A common disabling chronic neurological disorder characterized by an enduring propensity. Stem cell therapy is a promising treatment for the condition. The regenerative properties of stem cell-based treatment provide an approach for long-term seizure control, particularly in drug-resistant epilepsy. With the use of stem cells, we are able to replace damaged cells from seizures, restore cognitive function and stabilize focal electrical activity. This works by implanting healthy human brain cells into the damaged temporal lobe, which is what can lead to uncontrollable seizures if left unhealthy.

Stem cell therapy for schizophrenia

2023-11-09 08:55:11 UTC

Researchers are using stem-cell models to discover and experiment with the regenerative medicine outcomes for schizophrenia, one of the severe types of psychiatric disorders

Problem

2023-11-09 08:55:12 UTC

Spinal cord injury or SCI is damage to the nerves surrounding the spine. Some of the most common causes of SCI are motor accidents and falling. Over one million patients around the world are suffering from paralysis, a common effect of spinal cord injury.

Stem cell therapy for ischemic stroke

25nm16 — 2023-11-09 08:56:43 UTC

Ischemic stroke is the main subtype of stroke and occurs in about 70% of all stroke cases (85– 87% in the United States). Stem cells could prove to be what is one of the most promising treatments to ischemic strokes yet.

Results: The results of this study show promising and satisfying efficacy and a relatively low rate of serious adverse events.

Treatment

2023-11-09 08:58:54 UTC

A way spinal cord injury can be treated is through stem cells which can differentiate into neurons or glia in vitro.

STEM cell therapy(cardiovascular disease)

2023-11-09 13:42:18 UTC

Problem-

-Repairing damaged heart tissue from heart disease, such as heart attacks

The treatment-

-Injecting STEM cells into the heart

-Since the first transplantation into human patients, several stem cell types have been applied in this field, including bone marrow-derived stem cells, cardiac progenitors, embryonic stem cells, and their derivatives.

Advantages-

-This significantly lowered the number of people who experience heart attacks and strokes.

-adults who received and were treated with stem cell therapy for chronic, class II, or class III heart failure saw a 65% decrease in non-fatal heart attack or stroke events.

-A large number of clinical trials have shown stem cell therapy to be a promising therapeutic approach for the treatment of cardiovascular diseases.

Syngeneic stem cell transplants (for those with an identical sibling)

2023-11-09 13:52:35 UTC

Stem cells + PTSD

25aa99 — 2023-11-09 14:00:56 UTC

Stem cells are used to strengthen damaged parts of the brain and they fix abnormal neuron transmissions. The stem cells cause the prefrontal cortex to increase activity.

Stem cells + Erectile dysfunction

25bs1 — 2023-11-09 14:01:59 UTC

Erectile dysfunction (ED) is a medical condition characterized by the inability to achieve or maintain an erection sufficient for sexual intercourse. It is a common issue and can happen to men of all ages, although it becomes more prevalent with age. Erectile dysfunction can have both physical and psychological causes.

Stem cells specifically(vascular endothelial cells and VEGF) may be able to repair nerve and cavernous smooth muscle directly or indirectly, and finally polish up erectile function.

Stem cell therapy in heart failure.

2023-11-09 14:03:36 UTC

Stem cells can improve heart function in patients with congestive heart failure. Stem cells have been shown to stimulate the growth of new blood vessels and heart muscle cells, thereby improving cardiac function and blood flow and reducing inflammation in the heart. The treatment consists of depositing allogeneic mesenchymal stem cells inside the damaged heart tissue, to regenerate the worn-out tissue and cells that is affecting the patient's heart and not allowing it to function properly.

Treatment

25er11 — 2023-11-10 07:57:18 UTC

Stem cell therapy aims to replace damaged cells and promote tissue regeneration through differentiation. Obtained from a donor or the patient, stem cells are carefully prepared and are transplanted into the patient's spinal cord. In the spinal cord the cells are able to differentiate into various cell types which help in tissue repair.

The advantages of SCI

2023-11-10 08:00:07 UTC

SCI treatment results are very promising. The advantages include increased vascularization and suppressed cystic change. Another advantage is that most patients after the surgery found out that the stem cells improved their ASIA impairment scale score.

Mesenchymal stem cell therapy

2024-09-24 07:54:18 UTC

It has been conditionally approved for managing acute graft-versus-host disease (GVHD) in children who do not respond to steroids. This therapy utilizes mesenchymal stem cells derived from the bone marrow of adult donors to help modulate the immune response and reduce inflammation associated with GVHD.

Stem cell therapy for strokes

2024-09-24 07:57:20 UTC

Stem cell therapy is a promising approach for treating stroke, focusing on repairing damaged brain tissue and enhancing recovery. The main types of stem cells used are mesenchymal stem cells (MSCs) and induced pluripotent stem cells (iPSCs), both of which have demonstrated potential in clinical studies .

Stem cells injected into distant arteries or veins travel to the site of a stroke in the brain to fuel the repair process.

Stem Cell-Based Therapies for Parkinson Disease

2024-09-24 07:58:10 UTC

Typically, Parkinson's disease is a neurodegenerative disease which affects the motor and non-motor aspects of the body, usually affecting the elderly based on brain degeneration.

Recently, to treat this disease, researchers at the Harvard Stem Cell Institute have been treating Parkinson's with stem cell therapies, by generating brain cells which produce dopamine, collected from skin grafts.

This is done by receiving mature skin grafts and biologically reprogramming them to pluripotent cells into dopaminergic neurons.

Source: https://hsci.harvard.edu/parkinsons-disease-0

Stem cell therapy - damage to muscle cells

2024-09-24 07:58:44 UTC

In skeletal muscles, SCs (satellite cells) are adult stem cells that are used to repair tissue in a human body. They do this by maintaining the tissue homoeostasis and repair damaged areas after an injury, in order to preserve the skeletal musicals integrity.

Source: Yin, Hang, et al. "Satellite Cells and the Muscle Stem Cell Niche." PubMed, Jan. 2013

Stem Cell Therapy for Alzheimers -Malee and Laurasia

2024-09-24 07:59:42 UTC

Alzheimer's is a brain disease that causes you to have memory loss due to significant neuron loss. Stem cell therapy has made progress in the journey to find a cure. Stem cells replace damaged or lost neurons; induced pluripotent stem cells can be transplanted into the brain to regenerate healthy neurons and restore lost functions.

Source credibility: journal World J Stem Cells impact factor is 3.6

Retinal Stem Cell Transplantation

2024-09-24 09:35:00 UTC

Problem:

Degenerative diseases in the retina cause poor vision and blindness. Around 400 million people suffer from some retinal disease.

Treatment:

A variety of stem cells can be used in this treatment, with the most common ones being used (primarily in clinical trials for now) coming from retinal tissue (retinal pigment epithelial cells and photoreceptors). These stem cells are transplanted into the retina tissue, and replace the dysfunctional cells with the new retinal cells. This restores the retina function, if the transplant is successful.

Stem cell therapy for Parkinson's disease - Platon

2024-09-24 09:38:03 UTC

In the case of Parkinson's disease, stem cell therapy seeks to replace neurons responsible for producing dopamine. This approach entails the use of various sources in the production of the neurons. Current sources of such neurons include embryonic or induced pluripotent stem cells that undergo transplantation into the brain in order to reestablish proper levels of the neurotransmitter and help improve motor symptoms.

Stem cell therapy for oral health (Gums and teeth)

2024-09-24 09:38:13 UTC

Gum disease can also damage your bone tissues. Similarly, missing teeth can lead to bone resorption, which prevents your jaw from being able to receive implants or bridges. In cases like these, stem cell therapy can effectively regenerate gum or bone tissue. Also gum diseases like gingivitis can cause gum recession making teeth unhealthy, unprotected and look long. This gum recession is irreversible naturally but stem cell therapy can effectively regenerate gum tissue.

Stem cell therapy for cornea repair

2024-09-24 09:38:17 UTC

Stem cells from a patient’s healthy eye are removed and then expanded and grown through a manufacturing process. After 2-3 weeks, it will be transplanted into the eye with cornea damage.

Usage of stem cells in the treatment of diabetes type one

2024-09-24 09:38:37 UTC

It's when stem cell are used to grow insulin cells outside of the body of the patient. the insulin cells are produced in a lab then afterwards the transplanting lab-grown insulin-producing beta cells into the patient which will help balance the blood sugar levels

Heart failure

2024-09-24 09:39:00 UTC

heart failure is the number one killer, the main reason for heart failure is when the cardiomyocytes are injured (the cell responsible for contractions of the heart) there are no pharmaceutical or surgical solutions for this however scientist are looking into stem cells and they are close to starting the phase 1 of trials.

Stem cell treatment for arthritis

2024-09-24 09:39:15 UTC

Arthritis is a chronic autoimmune disorder that degenerates the function and quality of of the (synovium membrane) thin barrier which lines the inside of some joints. This results in bone destruction, chronic pain and cartilage destruction. MCS's are used to help repair the membrane between joints due to their substance which suppresses the immune system.