Human Gut Microbiome - Week 40 Q3 by Torben Sølbeck Rasmussen https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0 en-us 2022-09-26 09:51:33 UTC 2025-09-24 20:05:36 UTC hello@padlet.com Question: How could this animal model be improved? tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341332 •Discuss the following questions:
•What could the researchers have changed to improve the animal welfare in this model?
•What could have been a human endpoint? – when would it make sense to euthanize the animals?
•How are the transability of the study design (consider that the pathogen is foodborne)?
]]> 2022-09-26 09:52:31 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341332 Group 1 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341771 2022-09-26 09:52:54 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341771 Group 2 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341834 2022-09-26 09:52:57 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341834 Group 3 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341934 2022-09-26 09:53:03 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313341934 Group 5 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342420 They could have decided on some parameters in which the disease of the mice was so severe, that they should be euthanized. That could e.g. be when the mice had lost a certain amount of body weight. 

The results obtained in the study are not very translatable to humans. In humans the pathogen is food borne so it would have made sense to administer the pathogen to the mice orally.]]> 2022-09-26 09:53:30 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342420 Group 6 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342476 2022-09-26 09:53:33 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342476 Group 7 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342583 2022-09-26 09:53:39 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342583 Group 8 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342692 1. start from the bottom up in conc.
2. have some markers for pain and that the only way now is death
3. orally would be more appropriate in comparison to human getting food borne diseases]]> 2022-09-26 09:53:44 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313342692 Group 4 tsoelbeck https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313343491 2022-09-26 09:54:25 UTC https://padlet.com/tsoelbeck/dpdr3xgl7pcq17r0/wish/2313343491