https://padlet.com/kausallya/dm2euxcrcfbm1pqq MOD2 - DR RANIA (GROUP 6) en-us 2021-12-15 09:10:16 UTC 2022-01-21 16:22:36 UTC hello@padlet.com https://padlet.net/icons/png/263a.png kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004356020 For the first week, me and my teammates were given tasks by my lecturer. We were asked to go through the lab sheet attached in the e learning and then search for the compounds found in Covid-19 vaccines for their structures and mol file. This is because we have to use the mol file in the preADMET website to find the parameters and the values. This is the whole experiment for our group. So, before starting, as per my lecturer's request, I searched a few articles related to pharmacodynamics. pharmacokinetics, distribution of drugs and so on. Later on, Dr asked some questions to check whether we could understand the topics well before proceeding into the experiment. ]]> 2022-01-21 04:56:41 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004356020 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004359644 Later on, Dr divided our groups and asked us to divide into sub groups by ourselves. So, each sub group needs to choose a compound and then search for its structure and mol file. Later, we added the mol file in the preADMET website to get the parameters and their values. ]]> 2022-01-21 05:00:32 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004359644 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004361403 Since we needed to start doing the proposal for this experiment, our group divided the tasks for each and everyone. Later on, we started to do the proposal at the same time as when we were searching for the compounds that were suited and most commonly found in Covid-19 vaccines. ]]> 2022-01-21 05:02:19 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004361403 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004592524 For this week, we managed to finish up the proposal and then submitted to our Dr before the deadline. Later on, Dr commented on our proposal in every part and gave some tips and information to fix the proposal. ]]> 2022-01-21 08:24:56 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004592524 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004601909 Later, Dr asked us to start for our own individual reports to inform our works of what we did in that week and also for the group progress based on the compounds we had chosen. ]]> 2022-01-21 08:31:52 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004601909 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004620528 I asked for some guidance from the previous teams about the individual report. After that, we started to find journals related to my sub group compound. It is very hard to find and determine which parameter is under absorption, distribution, metabolism, excretion and toxicity. ]]> 2022-01-21 08:45:49 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004620528 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004704351  For this week, we did not have a general meeting with our Dr but she asked us to continue with our assigned tasks and send the individual reports for last week and this week and then report it to her before next meeting. ]]> 2022-01-21 09:46:23 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004704351 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004732906 It was hard to find the threshold range values for every parameter as to cross check the values given in preADMET. I searched for more journals to find out which parameter is under metabolism and excretion since for absorption and distribution, Anis was doing and for toxicity, Lily was doing it. ]]> 2022-01-21 10:07:15 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004732906 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004743347 I managed to find the affected organs for the parameters that I chose from the list which was divided among Anis and me. But the threshold values were hard to get. Hope I can find them as soon as possible. ]]> 2022-01-21 10:15:20 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004743347 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004758004 Each sub group had meeting according to the slot that Dr has separated for us. Me and my groupmates each presented our own individual reports and let Dr commented on them. She asked for several questions and gave us clues on what to find next so that we can report it to her for next week. ]]> 2022-01-21 10:26:35 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004758004 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004759556 I searched for the range values again and this time I tried to include the reference links so that it will be easier to be referred later on. ]]> 2022-01-21 10:27:37 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004759556 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004766226 I found few justifications to prove that why some of the parameters should not be included in the Covid-19 vaccines. I also found range values for very few parameters. Since my part was mostly related to metabolism and excretion, I had to read through many sources to understand about the CYP enzymes and how they work in the human body. Since our proposal was mainly focusing on the anaphylaxis, she asked us to find justifications based on the parameters and the anaphylaxis. ]]> 2022-01-21 10:32:46 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004766226 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004770249 For this week, we met Dr as per sub group and showed our updates. After looking through the justifications, she said it is still not strong enough to tell that the chosen parameters are related to anaphylaxis. It was quite hard for us, especially for me, since most of them are not really mentioning about the allergic reactions, instead they are mentioning about the effects of the enzymes when they are metabolized and inhibited. Dr gave me tips on how to search for it since these enzymes are mainly affected in metabolism and excretion. ]]> 2022-01-21 10:35:50 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004770249 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004799151 Dr also asked us to combine the sub group individual reports into one report and send it to her. However, I need to complete my parts before submitting it to Dr. ]]> 2022-01-21 10:58:58 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004799151 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004807056 I am still searching for the range of values.. it is not that easy to find them. The justifications are still on search for the CYP enzymes related with anaphylaxis. ]]> 2022-01-21 11:05:34 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004807056 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004816928 For this week's meeting, we had a group meeting with all the sub groups so that she can check all the updates from every sub group. After checking through all the updates, she commented on them. Later part, she explained to us about the final report submission and also for the presentation for next week. ]]> 2022-01-21 11:14:15 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2004816928 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2005341267 My group mates hurriedly did the presentation slides before the deadline so that we can send it to our Dr to recheck the slides before presenting. This is because Dr assured us that she will check the slides for us and correct it if there is any wrong in it since she is not the one who will put marks for us when presenting live.]]> 2022-01-21 16:19:52 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2005341267 kausallya https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2005347035 After the presentation, we need to focus on our report and make sure to pass it up before the deadline.

I must make sure my parts are well done with correct justifications and with correct information so that I will not give wrong information for my part in the report. ]]> 2022-01-21 16:22:36 UTC https://padlet.com/kausallya/dm2euxcrcfbm1pqq/wish/2005347035