Progeria by MATTHEW HAGEN https://padlet.com/21553/d9s4yhpruqhl Ethan Campbell and Matthew Hagen en-us 2016-02-12 16:30:08 UTC 2016-02-23 15:57:49 UTC hello@padlet.com Progeria disorder 89141 https://padlet.com/21553/d9s4yhpruqhl/wish/94882633 It is also called Hutchinson-Gilford progeria syndrome and benjamin button disease.]]> 2016-02-12 16:36:42 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/94882633 Gene location/karyotype  89141 https://padlet.com/21553/d9s4yhpruqhl/wish/94883369 Progeria is due to a "misspelling" in a gene on chromosome 1 that codes for lamin A. Misspelling in the lamin A gene is a substittion of just a single DNA base. Its a change from cytosine (C) to thymine (T).]]> 2016-02-12 16:39:45 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/94883369 How is it Classified? 21553 https://padlet.com/21553/d9s4yhpruqhl/wish/94884569 It is classified as single gene defect. It is autosomal dominant condition, and is X-linked dominant. ]]> 2016-02-12 16:43:56 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/94884569 signs and symptoms 89141 https://padlet.com/21553/d9s4yhpruqhl/wish/94884636 Hair loss (alopecia)
Aged-looking skin
Joint abnormalities
A loss of fat under the skin]]> 2016-02-12 16:44:07 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/94884636 life expectancy 89141 https://padlet.com/21553/d9s4yhpruqhl/wish/94884720 With progeria you get a higher risk of heart problems and strokes and that is the main cause of death. Usually a child lives to about 13 years old. Some kids die younger and some live to 20 and older.]]> 2016-02-12 16:44:24 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/94884720 Treatments 89141 https://padlet.com/21553/d9s4yhpruqhl/wish/95319715 Lonafarnib was originally made to treat cancer but was found effective for progeria. It improves patients in many ways: 
Gaining additional weight
Better hearing
improved bone structure
increased flexibility of blood vessels]]> 2016-02-16 16:01:23 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95319715 How it Arises 21553 https://padlet.com/21553/d9s4yhpruqhl/wish/95322314 The LMNA produces a lamin A Protein which is the structure that holds the nucleus of a cell together. The abnormal lamin A protein that causes progeria is called progerin. Progerin makes the nucleus unstable. The gene that causes progeria is a Dominat gene. ]]> 2016-02-16 16:08:39 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95322314 Gene Location 89141 https://padlet.com/21553/d9s4yhpruqhl/wish/95326383 https://www.google.com/url?sa=i&rct=j&q=&esrc=s&source=images&cd=&cad=rja&uact=8&ved=0ahUKEwiuqM272fzKAhWimoMKHR5kCpwQjRwIBw&url=https%3A%2F%2Fwww.haikudeck.com%2Fprogeria-slide-science-and-technology-presentation-K3fihiV6H0&bvm=bv.114195076,d.amc&psig=AFQjCNF6N-9YncY4FJ_OdU4mk4Y3cP63Mg&ust=1455726173141216]]> 2016-02-16 16:19:33 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95326383 21553 https://padlet.com/21553/d9s4yhpruqhl/wish/95326711 http://2011gtms8e.wikispaces.com/file/view/Jia_L_punnet.JPG/230368604/640x480/Jia_L_punnet.JPG]]> 2016-02-16 16:20:27 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95326711 How frequent it occours 21553 https://padlet.com/21553/d9s4yhpruqhl/wish/95327751 About 1 out of every 5 million new borns get progeria. It had been found in over 40 countries.]]> 2016-02-16 16:23:18 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95327751 Works cited 89141 https://padlet.com/21553/d9s4yhpruqhl/wish/95333706 "Hutchinson-Gilford Progeria Syndrome." Genetics Home Reference. N.p., n.d. Web. 16 Feb. 2016.
"Progeria." - Mayo Clinic. N.p., n.d. Web. 16 Feb. 2016.
"About Progeria." Progeria Research Foundation. N.p., n.d. Web. 16 Feb. 2016.]]> 2016-02-16 16:38:13 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95333706 How to Advise parents about it 21553 https://padlet.com/21553/d9s4yhpruqhl/wish/95333885 Having a kid with progeria is hard because they will have a shortened live span on average they only live to about 14 years old. Also it will be very expenis=ve for you]]> 2016-02-16 16:38:43 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95333885 Works Cited 21553 https://padlet.com/21553/d9s4yhpruqhl/wish/95334682 "Progeria." Coping and Support. Mayo Foundation, 3 May 2014. Web. 16 Feb. 2016.

"Learning About 
Progeria." Learning About Progeria. USA.Gov, 27 Dec. 2013. Web. 16 Feb. 2016.

"Progeria: Causes, Symptoms, and Treatments." WebMD. WebMD, n.d. Web. 17 Feb. 2016.]]> 2016-02-16 16:40:47 UTC https://padlet.com/21553/d9s4yhpruqhl/wish/95334682