Heart Disease by Brooklynn https://padlet.com/brooklynnrmoore/d7omuknty0e8 Brooklynn Moore and Anara Makahani en-us 2017-01-27 15:29:31 UTC 2025-10-11 17:14:41 UTC hello@padlet.com https://kimberlybiochemist.wordpress.com/tag/myocardial-cells-communication/ brooklynnrmoore https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/149917316
]]> 2017-01-27 16:03:20 UTC https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/149917316 Summary brooklynnrmoore https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150256953 Cells that are responsible for homeostasis in the cardiovascular system function by responding to extracellular receptors. Protein kinase and protein phosphatase enzymes phosphorylate proteins to change their shape and this is what helps signal recognition turn into a cellular response. ]]> 2017-01-30 15:14:43 UTC https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150256953 Small and frequent changes in the heart cause cells to act fast to maintain homeostasis. The crosstalk between signaling pathways responds to receptors. The cells then send specific signals across the crosstalk to intracellular receptors. The crosstalk, however, can cause chronic pathological changes in the cardiovascular system because of repeating protein (de)phosphorylation. Cardiac hypertrophy is the thickening of heart muscle and shrinkage of the chambers and can be caused by this process. brooklynnrmoore https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150557584 2017-01-31 15:25:32 UTC https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150557584 http://circres.ahajournals.org/content/112/7/1046/F3.large.jpg brooklynnrmoore https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150572257 2017-01-31 15:57:36 UTC https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150572257 ISCHEMIC INJURY brooklynnrmoore https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150573348
  • Ischemic injury is when there is a blockage in the heart muscle due to several factors, such as a poor diet. 
  • This leads to "oxidative stress" meaning that oxygen cannot reach the cells because of the blockage. 
  • This leads to ATP Depletion because no oxygen means no energy production. 
  • This lack of ATP production result in lack of proteasome function. Proteasomes help to get rid of bad and damaged proteins and if they have inhibited function there is a surplus in misfolded proteins.
  •  An increase in misfolded proteins leads to apoptosis and cardiomyopathies. 
    • ]]>     2017-01-31 15:59:57 UTC https://padlet.com/brooklynnrmoore/d7omuknty0e8/wish/150573348