Antibiotic/Antimicrobial Research Timeline by https://padlet.com/draxlere/d5q1iibxy6ie097f Made by Emma Draxler en-us 2020-05-16 22:06:37 UTC 2025-11-10 19:51:59 UTC hello@padlet.com Penicillin, discovered in 1928, is used for killing certain bacterial infections such as scarlet fever and erysipelas infections, it weakens the bacterial wall by deactivating the bacterial enzyme that builds the wall, broad spectrum, (quinolones, macrolides, aminoglycosides), yes there has been resistance to this antibiotic first case was in 1947 draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583840362 2020-05-20 01:51:07 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583840362 Prontosil, mid-20th century (1930s), used in the treatment of general bacterial infections in humans, prontosil interferes with the bacterial metabolism and kills the bacteria, broad spectrum, related to sulfonamide drugs, no antibiotic resistance draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583841162 2020-05-20 01:51:52 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583841162 Chlortetracycline, first invented in 1945, this treats skin infections, it kills invaders by repressing the growth of the bacteria, broad spectrum antibiotic, related to tetracycline, first resistance was recorded in 1953 draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583841634 2020-05-20 01:52:21 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583841634 Streptomycin, it was invented in 1943, used to treat bacterial infections such as tuberculosis and endocarditis, It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death, broad spectrum, related to a group of antibiotics called aminoglycoside, no resistance draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583842179 2020-05-20 01:52:57 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583842179 Chloramphenicol, discovered in 1947, used to treat bacterial infections such as meningitis and typhoid fever, chloramphenicol is a bacteriostatic by inhibiting protein synthesis. It prevents protein chain elongation by inhibiting the peptidyl transferase activity of the bacterial ribosome, broad spectrum, wasn’t able to find any related antibiotics, no resistance draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583843402 2020-05-20 01:54:07 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583843402 Erythromycin, discovered in 1949 and first used in 1952, treats certain infections of the respiratory system such as bronchitis, pneumonia, and Legionnaires' disease, it acts upon the invader by stopping the bacteria growth, broad spectrum, related antibiotics include Azithromycin and Carbomycin among others, no specific resistance found draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583843994 2020-05-20 01:54:45 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583843994 Vancomycin, invented in the 1950s, used to treat infections of the intestines and staph infections, broad spectrum, related antibiotics is ceftobiprole and iclaprim, first resistance happened in 1980s draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583844661 2020-05-20 01:55:26 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583844661 Streptogramin B, invented in 1962, effective in the treatment of vancomycin-resistant Staphylococcus aureus (VRSA) and vancomycin-resistant Enterococcus (VRE), two groups (A and M or B and S) kill targeted invaders by binding bacterial ribosomes and inhibiting protein synthesis at the elongation step and they act synergistically in vitro against many microorganisms,broad spectrum, related antibiotics include cyclic hexa- or hepta depsipeptides, first resistance in early 1970s draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583845224 2020-05-20 01:56:04 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583845224 Rifampicin, invented in 1965 but used in the US in 1971, used to treat or prevent tuberculosis and also reduces bacteria in your nose and throat, it stops the invader by inhibiting bacterial RNA polymerase, thus it is commonly used to inhibit the synthesis of host bacterial proteins during recombinant protein expression in bacteria, broad spectrum, related to Rimactane, first resistance in the late 1960s draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583845854 2020-05-20 01:56:43 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583845854 Fidaxomicin, invented in the mid 1970s, used to reduce the development of drug-resistant bacteria, It works by killing bacteria in the intestines, narrow spectrum, clarithromycin and erythromycin are related drugs, no specific resistance, could not find a resistance draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583846507 2020-05-20 01:57:19 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583846507 Daptomycin, invented in the early 1980s, treats bacterial infections of the skin and underlying tissues, including infections that have entered the bloodstream, they work by killing bacteria or preventing their growth, broad spectrum, related antibiotics include cyclic lipopeptide antibiotics, no specific resistance draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583846862 2020-05-20 01:57:42 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583846862 Linezolid, first invented in the mid-1990s and first approved for use in 2000s, fights bacteria in the body and other illnesses such as pneumonia, works to kill by inhibiting the initiation of bacterial protein synthesis, Broad spectrum, related antibiotics include paxil and prozac, no specific resistance draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583847268 2020-05-20 01:58:06 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583847268 Bedaquiline, first reported in 2005, used together with other medications to treat tuberculosis of the lungs that has been resistant to other antibacterial medications, it interferes with the function of an enzyme required by the tuberculosis bacterium to produce energy and to replicate, narrow spectrum, related antibiotics include diarylquinolines, first resistance in late 2000s draxlere https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583847740 2020-05-20 01:58:35 UTC https://padlet.com/draxlere/d5q1iibxy6ie097f/wish/583847740