Important insights into the pathophysiology of Alzheimer's Disease by Saffy https://padlet.com/saffymcglynn/cjaihq9e1mj Through the use of DNA Technology. en-us 2017-11-07 14:59:35 UTC 2017-11-29 13:48:49 UTC hello@padlet.com https://padlet-assets.s3.amazonaws.com/icons/Lightdecrease.png saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204388914 2017-11-07 15:14:06 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204388914 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204395369 2017-11-07 15:23:56 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204395369 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204416327 2017-11-07 15:53:57 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204416327 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204745529 2017-11-08 11:03:22 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204745529 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204753194 - DNA methylation plays an important role in memory and learning. Article provides an overview of methylation at Cytosine guanine rich sites.
- DNA methylation associated with neurodegeneration, aging and AD.]]> 2017-11-08 11:33:12 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204753194 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204761278 2017-11-08 12:03:21 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204761278 Genes associated with onset of AD - GWASs. saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204764039 1. Early - Amyloid precursor protein; Presenilin 1 and 2 (Linkage analysis).
2. Late - Apolipoprotein E. Base mutation in APOE associated with high risk of AD (SNP arrays).

PCR used to monitor mutations in AD risk factor genes. DNA extracted and amplified by primers designed for genes such as APOE. ]]> 2017-11-08 12:14:14 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204764039 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204769596 Public database summarising the potential genes that may be related to AD.]]> 2017-11-08 12:35:49 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204769596 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204769969 2017-11-08 12:37:03 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204769969 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204776320 2017-11-08 12:58:45 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204776320 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204785483 2017-11-08 13:23:06 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204785483 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204788978 Image - relationship between NFT, Extracellular Amyloid plaques and Cerebrovascular amyloid. ]]> 2017-11-08 13:31:05 UTC https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204788978 saffymcglynn https://padlet.com/saffymcglynn/cjaihq9e1mj/wish/204795395 -  Brain abnormalities in autopsy: decrease in neurone number of parietal lobes (memory function loss). 
Neurofibrillary tangles, extracellular amyloid plaques and cerebrovascular amyloid in cerebral cortex.

- Study attempts to establish origin of amyloid  plaque core protein. 
- DNA fragments detect mutations and diagnose AD. 

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