CCCCTC-binding factor by https://padlet.com/kaleb_barry/c4wb3toq11pc Made with good vibes en-us 2019-04-09 12:44:32 UTC 2025-05-01 19:38:14 UTC hello@padlet.com https://padlet-assets.s3.amazonaws.com/icons/Xmastree.png CCCTC-binding factor (CTCF) kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349898154 Location - 16q22.1
Exon Count - 13]]> 2019-04-09 12:45:59 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349898154 kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349899109 This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]]]> 2019-04-09 12:47:50 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349899109 kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349899450 Primarily expressed within the lymph nodes, but also expressed in many other tissues such as spleen, bone marrow, and endometrium. ]]> 2019-04-09 12:48:28 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349899450 Associated conditions kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349900280 - Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.]]> 2019-04-09 12:50:10 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349900280 HIV-1 Interactions kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349901595 Positional proteomics analysis identifies the cleavage of human CCCTC-binding factor (zinc finger protein) (CTCF) at amino acid residues 360-361 by the HIV-1 protease]]> 2019-04-09 12:52:53 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349901595 Homology kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349903534 CTCF is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.]]> 2019-04-09 12:56:56 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349903534 Functions kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349904313 2019-04-09 12:58:27 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349904313 kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349909256 2019-04-09 13:07:21 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349909256 kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349909359 2019-04-09 13:07:34 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349909359 Clinical Symptoms: kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349916817 2019-04-09 13:22:14 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349916817 Abnormality of the Head or Neck kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349918059 - Abnormality of the dentition
- Cleft Palate
- Microcephaly
- Thin vermilion border]]> 2019-04-09 13:24:33 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349918059 Abnormality of the Cardio Vascular System kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349918661 - Atrial septal defect
- Coarctation of aorta
- Patent ductus arteriosus ]]> 2019-04-09 13:25:42 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349918661 Abnormality of Digestive System kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349919502 - Feeding difficulties ]]> 2019-04-09 13:27:16 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349919502 Abnormality of the eye kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349920107 - Hypermetropia
- Strabismus]]> 2019-04-09 13:28:22 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349920107 Abnormality of Genitourinary System kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349920820 -Cryptorchidism]]> 2019-04-09 13:29:43 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349920820 Abnormality of musculature kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349921296 - Generalised hypotonia ]]> 2019-04-09 13:30:32 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349921296 Abnormality of Nervous System kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349921742 - Autistic Behaviour
- Intellectual disability ]]> 2019-04-09 13:31:30 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349921742 Abnormality of skeletal system kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349922267 - Microcephaly]]> 2019-04-09 13:32:25 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349922267 Growth Abnormality kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349922554 - Short Stature]]> 2019-04-09 13:32:58 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349922554 Alternative Promoter kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349925244 2019-04-09 13:37:56 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349925244 Mental Retardation, Autosomal Dominant 21 kaleb_barry https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349925730 https://www.ncbi.nlm.nih.gov/gtr/conditions/C3809686]]> 2019-04-09 13:38:48 UTC https://padlet.com/kaleb_barry/c4wb3toq11pc/wish/349925730