https://padlet.com/hglenville/c48s80eyqy00c4d4 en-us 2021-12-31 22:43:51 UTC 2022-01-04 20:09:46 UTC hello@padlet.com https://padlet.com/hglenville/c48s80eyqy00c4d4/wish/1975008548 This hormone helps regulate and alter long-term food intake and energy expenditure, not just from one meal to the next.

Produced by Adipose Tissue. The target organ is the brain (particularly the hypothalamus). 

Leptin is a mediator of long-term regulation of energy balance, suppressing food intake and thereby inducing weight loss. 

Leptin receptor deficiency is a condition that causes severe obesity beginning in the first few months of life. Affected individuals are of normal weight at birth, but they are constantly hungry and quickly gain weight. The extreme hunger leads to chronic excessive eating (hyperphagia) and  obesity.

treatment:
leptin treatment helps people with lipodystrophy follow a healthful diet. Without leptin, they are always hungry; leptin treatment dramatically reduces their appetite and thus also decreases their food intake. Leptin is the first approved therapy that is indicated for people with generalized lipodystrophy.


]]> 2022-01-04 19:40:42 UTC https://padlet.com/hglenville/c48s80eyqy00c4d4/wish/1975008548 https://padlet.com/hglenville/c48s80eyqy00c4d4/wish/1975009762 What is it:
- keeps you awake during the day and sleepy at night
- body reacts differently
     - core temp drops 
     - kidney receptors decrease urine
     -  all increase sleep
- travel
     - light no longer matches level in body
     - need few days to adjust to new light time
-  melatonin intake help with jet lag

Levels:
high = bed time
low = wake up

Where it is produced:
- found in pineal gland
     - small endocrine gland found near centre of brain
- controlled secretion

organ/structure it targets:
- brain = central and peripheral
- retina channels to cells in SCN, info is passed to pineal gland where it adapts to how much melatonin needs to be produced

Kognity - "It should be noted that melatonin receptors are also present on the neurons of the suprachiasmatic nuclei of most species, implying the possible involvement of a negative feedback loop in the regulation of melatonin"]]> 2022-01-04 19:41:09 UTC https://padlet.com/hglenville/c48s80eyqy00c4d4/wish/1975009762 https://padlet.com/hglenville/c48s80eyqy00c4d4/wish/1975056824 Thyroxine is the main hormone secreated into the bloodstream from the thyroid gland. The hormone targets all body cells and is vital in regulating the body’s metabolic rate, heart and digestive functions, muscle control, brain development and maintenance of bones. 

The main functions of Thyroxine is it's ability to activate nuclear transcription of large numbers of genes for the synthesis of enzymes, structural proteins and transport proteins, as well as increasing the metabolic activities of almost all the tissues of the body.  Thus, an increase in thyroxine causes an increased body temperature due to the increased pase of cellular respiration. 


Thyroxine deficienyc is caused by iodine deficiency and some symptoms include:
(due too decreased metabolic rate...)
- lack of energy 
- forgetfulness and depression 
- weight gain 
- feeling cold
- impaired brain development in children

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