https://padlet.com/e_alvey/bxgjg8hvqg57tz9x Ethics MBB262 2021 en-us 2021-03-18 22:51:14 UTC 2023-07-24 11:49:02 UTC hello@padlet.com e_alvey https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327852974 2021-03-18 22:57:20 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327852974 e_alvey https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327854698 2021-03-18 22:58:25 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327854698 e_alvey https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327864056 2021-03-18 23:04:20 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327864056 e_alvey https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327865418 CRISPR/Cas9 therapeutics. Used to treat solid tumours by creating lymphocytes that are PD1 knockouts. Engineering done Ex vivo and then introduced back into patient]]> 2021-03-18 23:05:07 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327865418 e_alvey https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327891909 Engineering human embryos to be resistant to HIV. CCR5 gene was exchanged for a variant that is associated with HIV resistance]]> 2021-03-18 23:20:59 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1327891909 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154244 Can be used to treat subjects with silver russel syndrome, by altering the epigenetics of the ICR1 gene, preventing inhibition of transcription of IGF2. When this is done in mice, there is a huge reduction in SRS symptoms.]]> 2021-03-19 10:16:34 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154244 jcihorton1 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154401 Several guide RNAs can be used at one time to generate large-scale chromosomal rearrangements to mimic rearrangements seen in heritable genetic disorders. Can be used to create disease models to help test drugs/treatments of such diseases]]> 2021-03-19 10:16:39 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154401 ebristow1 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154418 Could be possible for milk, peanuts, eggs etc. to become allergy-free by removing the part of the genome that causes the allergic immune response. Another group in the Netherlands is looking into modifying the DNA of wheat to remove gluten, so that its suitable for celiacs. ]]> 2021-03-19 10:16:40 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154418 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154980 Modification of gluten in wheat to allow coeliacs to be able to eat it. It requires removing the part of the antigen in which the immune system in coeliacs reacts to. Can be difficult as wheat has 6 copies of the chromosome, some of which have multiple gene copies. ]]> 2021-03-19 10:16:55 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329154980 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329155554 LCA is a genetic condition that causes blindness. CRIPSR system to be injected into the eye directly near photorecptors ]]> 2021-03-19 10:17:07 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329155554 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329161565 CRISPR/Cas9 can be used to treat Duchenne Muscular Dystrophy by correcting a mutation in the dystrophin gene - HDR repair or NHEJ. Deletion of exon 44 prevents premature stop codon in exon 45.

]]> 2021-03-19 10:19:24 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329161565 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329169398 2021-03-19 10:23:02 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329169398 ebristow1 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329201785 1) Make sure to outlaw any kind of genome editing that would allow for things such as designer babies, where parents can choose the traits of their child for a fee
2) Ensure strict regulation of all products; they need to go through rigorous trial phases before they are safe and brought to market.
3) Ensure no patents are able to be acquired, particularly in the early stages of a product being released to market, as this can greatly drive up the prices of products (for the company's own good) and lead to social inequality in terms of who can afford access to them. A lack of patents also allows for healthy competition within the market, furthering research into the CRIPSR technology and making it both safer, cheaper, and more effective.]]> 2021-03-19 10:38:38 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329201785 jcihorton1 https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329202824 1) Genome editing which can be passed down onto future human generations should not be allowed under any circumstances
2) Genome editing for therapeutic purposes should be subject to the same rules as other therapeutics
3) Any use of genome editing in humans should be as a last resort and undergo a thorough review process before proceeding - can we use other technology to have the same outcome
4) Permitted use of genome editing (regardless of if it only effects the individual, or future generations) should not risk increasing discrimination or stigmatisation of the characteristic changed]]> 2021-03-19 10:39:04 UTC https://padlet.com/e_alvey/bxgjg8hvqg57tz9x/wish/1329202824