https://padlet.com/chantelle_gauci/bso39io0k44a Implications of genetic testing and screening en-us 2018-08-27 10:54:01 UTC 2018-09-05 13:17:46 UTC hello@padlet.com chantelle_gauci https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275489949 A mutation in a gene that causes deafness has recently been identified.
A number of employers in the airline industry are concerned about this finding and want to screen prospective
new employees. They will refuse to employ people since they are concerned about the safety of their employees and customers, and possible litigation issues.

Should employers be allowed to screen potential employees using this genetic test? 

]]> 2018-08-27 10:58:38 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275489949 chantelle_gauci https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275490354 The parents of a five year old girl (Sofie) who has leukaemia are pleading to be allowed to select an embryo that will produce a brother or sister who can save her life. In an Australian test case
Leonard and Celeste Ryan want to use IVF combined with gene testing (Preimplantation Genetic Diagnosis or
PGD) to create and genetically select embryos that are a match for their five year old daughter.
Sophie has already undergone treatment including intensive chemotherapy, where 🤬 were injected into her
bloodstream everyday during long hospital stays.
Mrs Ryan said that she and her husband wanted another child anyway, provided the child was healthy and if the child could help Sophie what a blessing that would be.

If all goes well with the pregnancy, stem cells from the umbilical cord would be collected after the birth and
infused into Sophie's blood stream.

In a similar case, an American couple underwent four IVF treatment cycles, and of
five suitable embryos only one survived.

Imagine you are on the ethics committee hearing the Ryan's case. You have to make a decision on this procedure.]]> 2018-08-27 11:01:26 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275490354 chantelle_gauci https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275491771 Scientists have recently discovered a treatment that may offer new hope for boys with muscular dystrophy.
Muscular dystrophy makes muscles waste away. This is because the gene for a protein called dystrophin is
altered and leads to death of muscle fibres.
Researchers have submitted an application to their Research Ethics Committee to conduct clinical trials using a protein UTX on boys with muscular dystrophy. As there is no effective treatment now, they argue that clinical trials should start
immediately as this treatment is the only hope for those with muscular dystrophy.

Should clinical trials of UtX for boys with muscular dystrophy be approved? ]]> 2018-08-27 11:10:18 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275491771 chantelle_gauci https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275492997 Grace, a local school's bus driver, has had a hard time. Eighteen months ago her 34 year old brother died mysteriously in his
sleep, and just six months ago a young cousin collapsed and died at a rock concert. Grace has very few memories of her father, who died suddenly when she was just five years old. All three deaths were caused by
heart attacks.

After much deliberation Grace decided to undergo genetic testing. She was recently tested and found to have a gene
change (mutation) in the MYH7 gene associated with Hypertrophic Cardiomyopathy.

“Mr Moral Quandary works as the receptionist for Grace’s doctor. He is a member of school council, and his two
children aged 14 and 16 travels on the local school bus. He is aware of Grace’s test results and plans to inform school council of Grace’s genetic risk status.

What would you do if you were in Mr Quandary’s position? Would you inform school council, yes or no? 
 ]]> 2018-08-27 11:18:05 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/275492997 2355671 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390172 Informing the school would be a breach of Grace's privacy and it should not be Mr Quandary's  responsibility to inform the school as Grace should have done it. On the other hand, if the school doesn't know, it could put the children and parents that ride on the bus at potential risk if Grace were to suffer from a heart attack whilst driving. If I were in Mr Quandary's position, I would talk to Grace about the situation and encourage her to tell the school herself. ]]> 2018-09-04 01:14:51 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390172 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390206 In this scenario the school should be informed of Grace's condition, as it could be unsafe and could jeopardise the safety of the children. However it is not Mr Quandary's place to share this information as he is simply the receptionist at the doctor's clinic and thus would be a breach of privacy if he were to do so. Clearance from Grace herself would be needed if anyone wished to share this information and it should likely be herself or her doctor whom can pass on this information if required.]]> 2018-09-04 01:15:03 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390206 2355475 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390240 yes because as she is a school bus driver and has a chance of having a heart attack while driving, many children are at risk if something happens to her while driving. this may result in grace losing her job and therefor As Mr Quandary is part of the school council he could try and help grace to find another job.

Scenario 2
if there is no harm in the treatment then the cynical trails should be started

Scenario 3
I believe that this case should be approved as the family wants another child anyway. the second child in not getting harmed and also helping out the first daughter with leukaemia who is suffering

Scenario 4
yes has it is unsafe for the costumers and employees then all protection measures should be taken ]]> 2018-09-04 01:15:22 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390240 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390364 Scenario 1:
If I was in Mr Quandary's position I would inform the school council because Grace has a genetic mutation in her MYH7 gene and if the school council is not informed about it, she may also suffer from a heart attack like her 3 relatives. If the school council is informed, they would be able to effectively assist her in case of emergency. 

Scenario 2: 
Clinical trials of utx for boys with muscular dystrophy should be approved because this would lead to treatment for their muscles wasting away. As a result this could only improve their situation, not worsen it. 

scenario 3: I believe that it is unethical to have a child in order to make Sophie better. However, if this family truly does want another child and as a result can use her umbilical cord blood for Sophie, would in turn be ethical and very effective. ]]> 2018-09-04 01:16:27 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390364 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390392 Scenario 1;
Mr Quandary is not Grace's doctor who had finalised the results of the genetic condition of MYH7. Therefore by Mr Quandary informing the council about this condition would be a breach of Grace's privacy.
Scenario 2:
 Yes the treatment for muscle atrophy should be approved as it can provide a promising treatment for this muscular disorder.
Scenario 3: 

]]> 2018-09-04 01:16:44 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390392 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390604  I would not tell the school before asking for permission from Grace due to a preach of privacy. I would though convince Grace to inform the school due the risk it will cause on the children if she were to get a heart attack while driving the bus and so Grace can also have less pressure and stress to not increase the risk]]> 2018-09-04 01:18:18 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390604 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390615 Mr Moral Quandary should inform the school as it is a serious risk of not letting the school as something could happen to Grace unexpectedly. If the school is informed about the conditions that have happened to Grace they can become aware that it is common in her family and she also have been recently tested and results have shown that she also has Hypertrophic Cardiomyopathy ]]> 2018-09-04 01:18:25 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390615 2356316 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390622 If I was in Mr Quandary's position I would ask Grace for permission first if she would like me to tell the school and if she says yes, then I would inform the school privately because they need to be aware of Grace's condition and since she is a bus driver, they need to know if she's capable of continuing to drive the children safely to school. ]]> 2018-09-04 01:18:26 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390622 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390697 Scenario 4: No, because this may cause discrimination within the work industry and limit people's opportunities to develop their career. This test could be made available to the public in general not specific to the airline. If it is unsafe in general, it should probably be innovated so that its made safe.

]]> 2018-09-04 01:18:58 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390697 2356663 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390735 If I was in Mr Quandary's position I would inform family and Grace about the mutation that has occurred as well as finding out more about the mutation that she has encounter.

I would not inform the school because it is personal information unless I have permission from the family and Grace then yes I would inform the school council ]]> 2018-09-04 01:19:16 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390735 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390752 Scenario 1:
I would not tell the school council as it is a breach of Grace's privacy and is her decision. Instead I would make sure to have a discussion with her and allow her to think about her decision to inform the council because it will affect others lives.]]> 2018-09-04 01:19:21 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390752 2356540 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390753 In this scenario it talks about a treatment that can be used to potentially treat Muscular dystrophy. I believe that yes, the UtX treatment should be tested on boys with muscular dystrophy because it could mean that they get treatment and it may help them live longer because it is a disease that eats away at the body. I believe that it should be tested to them as long as it does no harm to them and no further damage. This could help them find a cure and find effective treatment.]]> 2018-09-04 01:19:22 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390753 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390801 I believe that employers shouldn't screen potential employees as it reduces the chances of others to gain employment because it does not consider other factors of the individual such as; if they are good at the job, and, if they've had a lot of experience working. It disadvantages those who have any sort of illness as employers look for people who are free from illness and disease. ]]> 2018-09-04 01:19:44 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390801 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390849 If I was in Mr Quandary's position I would not inform the school council, due to the fact it is not his place to tell the school Grace's results. Although, I would encourage Grace to tell the school council , I wouldn't tell them without her permis]]> 2018-09-04 01:20:08 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390849 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390857 Mr Moral Quandary should not inform the school as it is breaching Grace's privacy. Mr Moral Quandary should allow Grace to decide whether she should inform the school council of her condition.]]> 2018-09-04 01:20:12 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277390857 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277391065 I think that if boys and their parents give consent should be approved due to more trails with cures for muscular dystrophy such as UtX will improve the outcome and hope for those who suffer from muscular dystrophy
 ]]> 2018-09-04 01:22:04 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277391065 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277391278 yes clinical trails should be done as it is a serious degenerative disease that affects lives in a very horrible way, and having treatment or cure would improve quality of life for many people]]> 2018-09-04 01:23:43 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277391278 2356449 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277391425 She should tell the school because it may be a serious problem that might affect other lives.`]]> 2018-09-04 01:24:57 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277391425 https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277948336 In this specific scenario, the school should be informed of Grace's condition, which may potentially pose risk to the safety of the children riding on her school bus. However, it is not Mr Quandary's place to inform the School on Grace's condition. If I was in his position, I would encourage Grace to inform the school of her situation or attain permission from Grace, to inform the school either by myself or her doctor if she does not wish to do so.]]> 2018-09-05 13:10:32 UTC https://padlet.com/chantelle_gauci/bso39io0k44a/wish/277948336