Fragile X Syndrome (FXS) is a genetic condition, affecting around 1 in 4000 males and 1 in 6000 females. It can cause a wide range of difficulties with learning, as well as social, language, attentional, emotional, and behavioural problems. Some may experience connective tissue issues such as difficulty breast-feeding, hypotonia, hyperflexibility, flat feet, recurrent ear infections and mitral valve prolapse. FXS is the most common inherited cause of learning disability. https://www.fragilex.org.uk/syndrome

Signs:

• Signs that a child might have FXS include:

• Developmental delays (not sitting, walking, or talking at the same time as other children the same age);

• Learning disabilities (trouble learning new skills);

• Social and behavior problems (such as not making eye contact, anxiety, trouble paying attention, hand flapping, acting and speaking without thinking, and being very active).

Signs that a child might have FXS include:

• Developmental delays (not sitting, walking, or talking at the same time as other children the same age);

• Learning disabilities (trouble learning new skills); and

• Social and behavior problems (such as not making eye contact, anxiety, trouble paying attention, hand flapping, acting and speaking without thinking, and being very active).

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  Early Intervention Services

  Early intervention services help children from birth to 3 years old (36 months) learn important skills. These services may improve a child’s development. Even if the child has not been diagnosed with FXS, they may be eligible for services. These services are provided through an early intervention system in each state. Through this system, you can ask for an evaluation. In addition, treatment for particular symptoms, such as speech therapy for language delays, often does not need to wait for a formal diagnosis. While early intervention is extremely important, treatment services at any age can be helpful

It is caused by changes in a gene called Fragile X Messenger Ribonucleoprotein 1,which makes a protein called FMRP that is needed for brain development. People who have FXS do not make this protein.

FXS affects both males and females.

Females often have milder symptoms than males. The exact number of people who have FXS is unknown, but a review of research studies estimated that about 1 in 7,000 males about 1 in 11,000 females have been diagnosed with FXS.

Signs that a child might have FXS include:

• Developmental delays (not sitting, walking, or talking at the same time as other children the same age);

• Learning disabilities (trouble learning new skills); and

• Social and behavior problems (such as not making eye contact, anxiety, trouble paying attention, hand flapping, acting and speaking without thinking, and being very active).

Males who have FXS usually have some degree of intellectual disability that can range from mild to severe.

Females with FXS can have normal intelligence or some degree of intellectual disability.

Autism spectrum disorder (ASD) also occur more frequently in people with FXS.

There is no cure for FXS. 

https://www.cdc.gov/ncbddd/fxs/facts.html