History of Hemophilia by Orie Tyler

First known; The Beginning

otisabeast10 — 2024-05-20 05:30:38 UTC

The first known reference to bleeding disorder appears in the Talmud, describing the practice of exempting boys from circumcision if two previous brothers had died from bleeding after the procedure.

1803; First recognition by Doctor

otisabeast10 — 2024-05-20 05:33:33 UTC

Dr. John Conrad Otto, a physician in Philadelphia, is the first to recognize hemophilia as a bleeding disorder, noting its prevalance in certain families.

3. 1928

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The term "Hemophilia" is coined by Friedrich Hopff, a student at the University of Zurich, to describe the bleeding condition.

4. 1937

otisabeast10 — 2024-05-20 05:52:11 UTC

The discovery of anti-hemophilic globulin (AHG), now known as factor Vlll, by Dr. Patek and Dr. Stetson, is a major milestone in understanding the clotting process.

5. 1952

otisabeast10 — 2024-05-20 05:55:20 UTC

Hemophilia B, also known as Christmas Disease, is identified as a separate condition from Hemophilia A, due to its deficiency in factor IX. It is named after Stephen Christmas, the first patient diagnosed with the disorder.

6. 1960's

otisabeast10 — 2024-05-20 05:58:59 UTC

The development of cryoprecipitate, a plasma fraction rich in factor VIII, revolutionizes treatment for Hemophilia A, allowing for more effective control of bleeding episodes,

7. 1980's

otisabeast10 — 2024-05-20 06:01:02 UTC

The AIDs epidemic devastates the Hemophilia community, as many patients contract HIV through contaminated blood products.

8. 1985

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Heat treatment of blood products is introduced, significantly reducing the risk of viral contamination (which includes HIV and hepatitis) in clotting factor concentrates.

9. 1992

otisabeast10 — 2024-05-20 06:07:56 UTC

Recombinant clotting factors, which are genetically engineered and free human blood, become available, offering a safer treatment option for Hemophilia patients.

10. 2017-current

otisabeast10 — 2024-05-20 06:10:16 UTC

The first gene therapy for Hemophilia is approved for clinical use, offering the potential for long-term control or even a cure for the disorder.