https://padlet.com/inaara_hassam/akd8aj5s4zs9 DNA vaccines - Influenza Virus en-us 2017-11-27 16:30:10 UTC 2025-06-02 08:20:42 UTC hello@padlet.com inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210512037 Ferraro, B., Morrow, M., Hutnick, N., Shin, T., Lucke, C. and Weiner, D. (2011). Clinical Applications of DNA Vaccines: Current Progress. Clinical Infectious Diseases, [online] 53(3), pp.296-302. Available at: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202319/ [Accessed 20 Nov. 2017].]]> 2017-11-27 16:48:52 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210512037 inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210519527 -  Understanding the basic biology behind this deceptively simple vaccine platform 
- Investigate technological advancement to enhance immune potency.]]> 2017-11-27 17:00:47 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210519527 inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210519689 - Live-attenuated vaccines can mobilize both the cellular and humoral arms of the immune response and generally induce more-prolonged immunity. ]]> 2017-11-27 17:01:04 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210519689 inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210519907 -  Several physical methods of delivery have been explored to increase the transfection efficiency of DNA vaccines, including needle-free approaches, such as particle bombardment and high-pressure delivery, dermal patches, and electroporation (EP). ]]> 2017-11-27 17:01:28 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210519907 inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210520018 - The DNA platform is conceptually safer and more stable than are conventional vaccine approaches. Plasmids are nonlive and nonreplicating, which leaves little risk for reversion to a disease-causing state or secondary infection. 
- Advancements in antigen design, improved formulations, inclusion of molecular adjuvants, and physical methods of delivery have greatly enhanced the immunogenicity of second-generation DNA vaccines.
- Research is still continuing to explore combining other vaccine platforms with DNA, enhanced methods for delivery, and new molecular adjuvants.]]> 2017-11-27 17:01:40 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210520018 inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210520179 - Formulation of DNA vaccines in microparticles or liposomes has been reported to increase the uptake of plasmid DNA by cells, thereby increasing the immunogenicity of several different vaccines in animal models and humans .
- Another method to improve DNA vaccine immunogenicity is the inclusion of additional plasmids.  Unlike traditional adjuvants, which stimulate nonspecific inflammation, molecular adjuvants can modulate the adaptive immune response. 
-  EP also increases the uptake of DNA plasmids by cells, resulting in an increase in antigen production and in vaccine immunogenicity]]> 2017-11-27 17:01:53 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210520179 inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210644988 2017-11-27 20:22:33 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210644988 inaara_hassam https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210701898 2017-11-27 23:36:25 UTC https://padlet.com/inaara_hassam/akd8aj5s4zs9/wish/210701898