regeneration in the CNS by Lauri Keogh https://padlet.com/keoghl/ai52fc3okmtciihj week 7 en-us 2022-02-22 14:47:30 UTC 2022-02-22 20:17:01 UTC hello@padlet.com 1. What types of geographic lesions occur to brain tissue? keoghl https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060711442 2022-02-22 14:48:12 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060711442 2. what happens to injured/dying neurons of the CNS? keoghl https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060712333 2022-02-22 14:48:36 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060712333 3. how do the CNS and PNS compare with regeneration and repair? keoghl https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060714995 2022-02-22 14:49:32 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060714995 4. list 3 mechanisms of CNS recovery, describe keoghl https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060715763 2022-02-22 14:49:52 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2060715763 1. https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061315593 ·         Focal lesions - Injury remains in a specific region of the brain, giving them more predictable manifestations
·         Hypoxia- Decreased oxygen to the brain
·         Anoxia- No oxygen to the brain
·         Causes may include near drowning, heart attacks, surgical procedures 

]]> 2022-02-22 20:02:19 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061315593 2. https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061321722 Injured neurone in the CNS cause swelling in the brain, which is not always a good thing because there is nowhere for the extra fluid to go, so this causes encephalopathy. 

The cell bodies may rupture, causing their contents (neurotransmitters, enzymes, etc.) to spill out and possibly damage nearby cells, so the damage spreads to other sites of the brain than just the initial injury. The excess of blood in the brain means it has nowhere to go, so it may congeal and calcify, further damaging other parts of the brain because it blocks the healthy blood supply. ]]> 2022-02-22 20:06:15 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061321722 https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061322344 4.


  1. Axonal Sprouting:     when an incomplete SCI occurs, some of the unaffected neurons sprout new branches to the injured areas which restores some of the sensory/motor functions in those areas.
  2. Activation of parallel pathways: neurons rewire to take on new roles; this is often facilitated by rehab.
  3. Neurogenesis: when new neurons grow; involved in physical and mental activity.
  4. Olfactory epithelium adds new neurons and replaces them over time

]]> 2022-02-22 20:06:46 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061322344 3 aziz0041 https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061335941 CNS-Lacks the growth factors needed for axon growth and regeneration
CNS injuries have limited ability to heal
PNS-Contain growth factors that assist with axon regeneration
PNS injuries can heal more effectively
]]> 2022-02-22 20:15:32 UTC https://padlet.com/keoghl/ai52fc3okmtciihj/wish/2061335941