Chapter 11: Antimicrobial Drugs by John Campetella https://padlet.com/jcampetella/a9q0rmd27okbi3o1 en-us 2021-07-28 12:27:55 UTC 2021-07-28 21:45:00 UTC hello@padlet.com Antimicrobial Drug Actions jcampetella https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663082629 2021-07-28 12:31:51 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663082629 jcampetella https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663083358 Discuss the Therapeutic Index and possible side effects used by these drugs. ]]> 2021-07-28 12:33:13 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663083358 jcampetella https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663084792 Describe the five basic categories of mechanisms used by antimicrobial drugs]]> 2021-07-28 12:35:42 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663084792 jcampetella https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663085368 Explain what is meant by selective toxicity.]]> 2021-07-28 12:36:43 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663085368 jcampetella https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663086211 https://quizlet.com/22029377/microbiology-chapter-20-antimicrobial-drugs-flash-cards/]]> 2021-07-28 12:38:14 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663086211 Trish https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663439897 The goal is to interfere with the metabolism or structure of an organism to the point that it can no longer survive or reproduce. 

]]> 2021-07-28 21:25:30 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663439897 Kathleen https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663439979 The goal is to interfere with the metabolism or structure of an organism to a point that it can no longer survive or reproduce.]]> 2021-07-28 21:25:44 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663439979 Prince https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663440970 Selective toxicity means that a chemical produces injury to one kind of living matter without harming another form of life even though the two may exist in intimate contact.]]> 2021-07-28 21:27:42 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663440970 Trish https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441412 Therapeutic index is an assessment of the risks and benefits of a drug. Side effects include diarrhea, UTI's, yeast infections, irregular heartbeat and cardiac arrest.]]> 2021-07-28 21:28:39 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441412 Shekira https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441447 The goal of antimicrobial drugs is to interfere or disrupt the structures of an organism so that it can't survive or reproduce.]]> 2021-07-28 21:28:43 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441447 MbangeT https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441516 They interfere with the life cycle of organisms and alter it. They do this by binding to the target  thus altering the normal function of the bacterium.]]> 2021-07-28 21:28:53 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441516 Prince https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441693 The five basic categories of mechanisms used by antimicrobial drugs are: 
1.Cell wall synthesis inhibition

2.Protein synthesis inhibition

3.Nucleic acid synthesis inhibition

4.Cell membrane disruption

5.Metabolic antagonism/disruption
]]> 2021-07-28 21:29:19 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441693 Erica-the goal is to kill or inhibit bacterial growth where the infection occurs. https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441703

]]> 2021-07-28 21:29:19 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663441703 Ingrid https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442225 Antimicrobial medications work by inhibiting growth, or destroy bacteria

]]> 2021-07-28 21:30:39 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442225 Trish https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442363 Change in membrane permeability - allows changes in proteins of the plasma membrane to interfere with the transport mechanism which may prevent some antibiotics from crossing the membrane to enter the cell;
Increased drug elimination - protein pumps are encoded in plasmids or chromosomes and are capable of removing a variety of antimicrobial drugs, detergents and other substances toxic to the microbe;
Change in the target (receptor) of the agent - Microbes can avoid attack by antimicrobials by altering the drug target.
Change in a metabolic pathway - Microbes can develop an alternative metabolic pathway or enzyme that allows the bypassing of a metabolic reaction that could be inhibited by an antibiotic;
Change in a previously inhibited enzyme - Modifying an enzyme may prevent a reaction or series of reactions in a bacterial cell.]]> 2021-07-28 21:30:53 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442363 Krishna https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442371 The goal of any antimicrobial agent is to interfere with the metabolism or structure of any organism to a point that is can no longer survive or reproduce]]> 2021-07-28 21:30:53 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442371 Erica-Therapeutic index is the level of safety between the therapeutic dose vs the toxic dose. https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442806 2021-07-28 21:31:52 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442806 Paula https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442890 to interfere with the metabolism or structure of any organism so it cannot siervive]]> 2021-07-28 21:32:06 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442890 Ingrid https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442904 Therapeutic index is the measurement of safety level of a drug. Side effects of the use of antimicrobial medications include yeast infections due to an inbalancce in the ph and natural flora. ]]> 2021-07-28 21:32:07 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663442904 Prince https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443520 Therapeutic index is the margin of safety that exists between the dose of a drug that produces the desired effect and the dose that produces unwanted side effects]]> 2021-07-28 21:33:38 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443520 Lori https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443631 Therapeutic index is the level of a drugs therapeutic and toxic levels]]> 2021-07-28 21:33:55 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443631 jamilah https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443635 the goal is to interfere with the metabolism or structure of an organism so it can no longer survive or reproduce]]> 2021-07-28 21:33:56 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443635 Ingrid https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443746 1. Cell wall synthesis-
2.Protein synthesis-
3/4. RNA and DNA synthesis
5.intermediary metabolism]]> 2021-07-28 21:34:14 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443746 Kathleen https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443771 Therapeutic index is the safety level of the drug. Side effects would include; diarrhea (most common), UTI's, yeast infections, or cardiac complications. ]]> 2021-07-28 21:34:18 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663443771 Lori https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444039 Inhibition of cell wall synthesis, inhibition of nucleic acid synthesis, distribution of plasma membrane, inhibition of metabolic pathways]]> 2021-07-28 21:35:07 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444039 Paula https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444526 an ideal antimicrobial drug will kill harmful microorganisms, without significant damage to the host.]]> 2021-07-28 21:36:24 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444526 Erica-There is the inhibition of cell wall synthesis-this is where peptidoglycan a tough type of structure bacteria has which protects the cells. Inhibition of protein synthesis-the translation of mRNA is disrupted in this process. Inhibition of Nucleic Synthesis- https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444529 2021-07-28 21:36:24 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444529 jamilah https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444791 theraputic index is the dosage that is safe and causes therapuetic effects vs undesirable effects.

]]> 2021-07-28 21:37:04 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444791 Lori https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444886 Selective toxicity is when a drug will kill a harmful microorganism without significant damage to the host.]]> 2021-07-28 21:37:20 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663444886 Prince https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663445171 The general goal of antimicrobial drug action is to eradicate microbes at the site of an infection. ]]> 2021-07-28 21:38:04 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663445171 Ingrid https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663445233 Selective toxicity refers to antimicrobials that are harmful to the microbe without causing harm to the host.]]> 2021-07-28 21:38:13 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663445233 Paula spectrum of action, its selective toxicity, whether is microbicidal rather than microbiostatic, how readily and easy may be deliver to the site of infection https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663445234 2021-07-28 21:38:13 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663445234 Krishna https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446733 The five basic categories are 
Cell wall synthesis inhibition
Protein synthesis inhibition
Nucleic acid synthesis inhibition
Cell membrane disruption
Metabolic antagonism/disruption]]> 2021-07-28 21:40:07 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446733 Trish https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446747 An agent is toxic to the target microorganism but less toxic to cells of the host.

]]> 2021-07-28 21:40:09 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446747 jamilah https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446750 cell wall synthesis inhibition
protein sythesis inhibition
nucleic acid synthesis inhibition
cell membrane disruption
metabolic antagonism/disruption]]> 2021-07-28 21:40:09 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446750 Kathleen https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446981 The 5 basic categories of mechanisms used by antimicrobial drugs are; cell wall synthesis inhibition, protein synthesis inhibition, nucleic acid synthesis inhibition, cell membrane disruption, and metabolic disruption. ]]> 2021-07-28 21:40:46 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663446981 Lori https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663447379 the goal is to interfere with the metabolism or structure of an organism]]> 2021-07-28 21:41:55 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663447379 Kathleen https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663447696 selective toxicity refers to antimicrobials that are harmful to the microbe without causing harm to the host.]]> 2021-07-28 21:42:53 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663447696 jamilah https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663447821 drugs harm the microbe without causing significant damage to the host]]> 2021-07-28 21:43:14 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663447821 Erica-the ability of the antimicrobial drug to harm the microbe without harming the host. https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663448161 2021-07-28 21:44:12 UTC https://padlet.com/jcampetella/a9q0rmd27okbi3o1/wish/1663448161