Von Willebrand Disease by Gabby D. https://padlet.com/gab3836/Bookmarks Made with a quick smile en-us 2022-05-30 18:01:33 UTC 2024-03-29 00:49:57 UTC hello@padlet.com gab3836 https://padlet.com/gab3836/Bookmarks/wish/2204944527 2022-05-30 18:13:00 UTC https://padlet.com/gab3836/Bookmarks/wish/2204944527 Signs and Symptoms https://padlet.com/gab3836/Bookmarks/wish/2204945415 Frequent or Hard-to-Stop Nosebleeds
  • Occurs often (5 or more times a year)
  • Last more than 10 minutes
  • Occur spontaneously, without injury
  • Need packing or cautery
Easy Bruising
  • Occurs with no trauma or injury
  • Occurs often 
  • Appearance: 2.5 cm or larger and raised
Heavy Menstrual Bleeding
  • Gushing of blood
  • Large clots
  • Soaking through a pad or tampon every 1-2 hours
  • Diagnosed with anemia
Longer than Normal Bleeding after Injury, Surgery, Childbirth, or Dental Work
  • Bleeding last more than 5 minutes after a cut to the skin
  • Heavy, prolonged bleeding after surgery or childbirth
  • Surgery site oozes blood longer than 3 hours after surgery
  • Blood in stool or urine

]]> 2022-05-30 18:14:12 UTC https://padlet.com/gab3836/Bookmarks/wish/2204945415 What is Von Willebrand Disease (VWD) https://padlet.com/gab3836/Bookmarks/wish/2204949008 VWD is a blood disorder in which the blood lacks proteins that inhibit clotting when needed.]]> 2022-05-30 18:18:58 UTC https://padlet.com/gab3836/Bookmarks/wish/2204949008 Lab Tests: gab3836 https://padlet.com/gab3836/Bookmarks/wish/2204950259
  • Factor VIII clotting activity―To measure the amount of factor VIII in the blood
  • Von Willebrand factor antigen―Measures the amount of VWF in the blood
  • Ristocetin cofactor or other VWF activity―Measures how well the VWF works
  • Von Willebrand factor multimers―To measure the makeup or structure of the VWF
  • Platelet aggregation tests―Measures how well the platelets are working
    • (CDC, 2021)
    ]]>     2022-05-30 18:20:35 UTC https://padlet.com/gab3836/Bookmarks/wish/2204950259     Typical Lab Results gab3836 https://padlet.com/gab3836/Bookmarks/wish/2204953373 2022-05-30 18:24:53 UTC https://padlet.com/gab3836/Bookmarks/wish/2204953373 Types of VWD https://padlet.com/gab3836/Bookmarks/wish/2204953553 Type 1 
    • Most common and mildest form
    • Lower than normal Von Willebrand factor (VWF)
    • About 85% of people treated for VWD have Type 1
    Type 2
    • Have normal VWF but the factor doesn't work correctly
    • Type 2A, VWF is not the proper size and doesn't help platelets attach together
    • Type 2B, VWF attaches to platelets when there is no injury and the body removes platelets with VWF, decreasing platelets and VWF when it's needed
    • Type 2M, VWF does not attach to platelets
    • Type 2N, VWF attaches to platelets but does not attach to Factor VIII, which is also needed to clotting
    Type 3
    • Most severe form of VWD
    • Individual has little to no VWF and low factor VIII
    • 3% of people with VWD have Type 3

    ]]>     2022-05-30 18:25:07 UTC https://padlet.com/gab3836/Bookmarks/wish/2204953553     References: gab3836 https://padlet.com/gab3836/Bookmarks/wish/2204955498 Centers for Disease Control and Prevention. (2021). What is von willebrand disease? Centers for Disease Control and Prevention. Retrieved May 30, 2022, from https://www.cdc.gov/ncbddd/vwd/facts.html

    Roberts, J. C., & Flood, V. H. (2015). Laboratory diagnosis of von Willebrand disease. International journal of laboratory hematology, 37 Suppl 1(Suppl 1), 11–17. https://doi.org/10.1111/ijlh.12345]]>     2022-05-30 18:27:43 UTC https://padlet.com/gab3836/Bookmarks/wish/2204955498     gab3836 https://padlet.com/gab3836/Bookmarks/wish/2204959430 2022-05-30 18:33:00 UTC https://padlet.com/gab3836/Bookmarks/wish/2204959430 gab3836 https://padlet.com/gab3836/Bookmarks/wish/2204969013 2022-05-30 18:45:22 UTC https://padlet.com/gab3836/Bookmarks/wish/2204969013 Risk Factors https://padlet.com/gab3836/Bookmarks/wish/2206528190
  • Family history of the disease
    • Autosomal dominant gene
    • only need one copy of the mutation to inherit it
  • Very rarely acquired
    • hyperthyroidism
    • ]]>     2022-05-31 18:57:05 UTC https://padlet.com/gab3836/Bookmarks/wish/2206528190     Video gab3836 https://padlet.com/gab3836/Bookmarks/wish/2206598827 2022-05-31 20:07:58 UTC https://padlet.com/gab3836/Bookmarks/wish/2206598827