From Rome with no stop flights it takes more less 11 hours and 10 minutes with this companies:

KLM    from  €1,087 
AIR FRANCE   from €1,087
DELTA   from €1,087
ALITALIA   from €1,090

Today is your day for total relaxation and fun. Take a day trip to Key West and do nothing but lounge and enjoy the sunshine and waves. Or, you can opt to shop, dine, and otherwise explore Key West itself.Some optional activities you can do while in Key West include paying a visit to the Hemingway house, hopping aboard an eco-kayaking adventure, or setting sail on a dolphin-watching cruise.Whatever suits your fancy, you’ve got all day in Key West to enjoy it. Be sure to time your trip so that you see the setting sun in Mallory Square — you’ll get some of the most beautiful photos you’ll ever take.

This tour will take the entire day, beginning early in the morning.

Stop #1: Duck Tours South Beach

Take your last day in Miami to spend a little more time in South Beach.The Duck Tours South Beach will give you a broad overview of the highlights and hotspots of South Beach and beyond, providing some really stellar photo opportunities.Some highlights of your tour will include the Art Deco District, Fisher Island, Millionaire’s Row, and Star Island, among many others.Plus, your tour guide is a professionally trained actor and comic who is sure to delight passengers the entire time.This tour lasts approximately 90 minutes.

Lunch in South Beach

For lunch, we especially recommend the beachside News Café, the perfect people-watching locale.There are also many other dining options to consider along the beach, featuring everything from Italian and Thai food to authentic Cuban cuisine and high-end steaks.

Stop #1: Big Bus Miami Sightseeing Tour

This hop-on, hop-off tour is an ideal introduction to the city of Miami itself. Big Bus Miami will take you throughout the city and the surrounding neighborhoods, hitting all the major highlights and hotspots.

Some included sights on your tour include the Vizcaya Museum, the Freedom Tower, and much much more.

Remember to pick up your ticket in advance at the Big Bus Miami Central Station. You can choose to hop on or off at any of the stops along the way, or, stay on for the full length of the tour.

Once you’ve returned to Miami, head to one of their most famous neighborhoods for some authentic Cuban cuisine.
There’s a wide variety of styles and prices, but it’s all delicious!

Stop #2: Everglades Tour

This Everglades Tour (departing from Miami) is the perfect way to see and experience the fantastic natural world of the Florida Everglades.
It’s a half-day long excursion that exposes you to the wild and wonderful throughout the swamplands.
Take an airboat ride, marvel at the Wildlife Nature Show, stroll the Jungle Walkway, and more at this enchanting attraction.
Don’t forget your camera to capture some photos of the iconic Florida alligator (from a safe distance, of course)!
This tour lasts approximately 5 hours.

Stop #3: Jungle Island

Jungle Island is a magical place to visit. If you’ve used the Big Bus sparingly, you have plenty of time to explore this fascinating and educational attraction.
Part animal park, part discovery center, Jungle Island is fun for the whole family.
Exhibits feature some of the world’s rarest and most exotic species, from large mammals and primates to fish and plants.
You can also participate in VIP tours and animal interactions to enrich your experience. Check out their special shows for some more animal fun, too! Choices included “Winged Wonders,” “Wild Encounter,” and “Wild Adventures.”
We recommend reserving between 2-3 hours for this attraction.

Dinner in Miami Beach

This restaurant haven is filled with beachside dining options known for their delicious seafood.
You must dine in Miami Beach at least once during your vacation, even if only to enjoy the scenery – many restaurants have gorgeous waterfront views!

Stop #2: Miami Seaquarium

Located on lovely Virginia Key, the Miami Seaquarium is the premier destination for all things marine life in Miami.
Filled with exciting animal shows, educational exhibits, and informative presentations, an afternoon at the Seaquarium will delight the whole family.
This institution is also dedicated to wildlife conservation and rescue, so many of the creatures that call the Seaquarium home have actually been rescued and rehabilitated from the wild.
Be sure to pay a visit to the manatees, who represent the single largest population of rescued marine creatures at the park.
We recommend reserving about 2 hours for this attraction.