https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4 en-us 2022-10-19 17:04:26 UTC 2022-11-06 23:52:29 UTC hello@padlet.com maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2347452914 2022-10-19 17:09:16 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2347452914 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2347456018 2022-10-19 17:10:29 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2347456018 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2347457326 2022-10-19 17:11:09 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2347457326 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2368278734 2022-11-03 11:38:39 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2368278734 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369205337 - Most common type of Albinism
- A rare genetic disorder
- Affects the pigmentation in skin, hair, and eyes
- 7 types of OCA (OCA1 - OCA7)
- OCA 1 is further divided up into OCA 1A & OCA 1B  as their affected areas are different.]]> 2022-11-03 22:45:16 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369205337 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369256246 Overall the skin pigmentation depends on three things:
- Carotene pigments in subcutaneous fat (adipose tissue)
- Amount of blood and how much oxygen its carrying (hemoglobin)
- Amount of a melanin pigment (tyrosinase enzyme)]]> 2022-11-03 23:58:02 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369256246 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369260081 Mutations of tyrosine gene (TYR) causes melanocyte cells to produce little to no melanin, resulting in insufficient amount of melanin pigment in skin, hair and eyes.]]> 2022-11-03 23:59:56 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369260081 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369277422 - Absent skin pigmentation
- Reduced pigmentation of hair and eyes
- Ocular albinism
- Photophobia
- Patchiness on the skin
- poor depth perception

These symptoms may be different from person to person. Some people may have more symptoms than others and symptoms can range from mild to severe. ]]> 2022-11-04 00:14:38 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369277422 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369292639 Seven genes have been identified that are associated with different types of OCA - each of which is important in the production of melanin pigment.


OCA 1 is associated with mutations in the Tyrosinase Gene (TYR). ]]> 2022-11-04 00:28:05 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369292639 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369300109 Chromosome location (OCA 1): 11q14-q21]]> 2022-11-04 00:33:14 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369300109 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369318660 This gene is responsible for the creation of Tyrosinase Enzyme which begins the process of Melanogenesis (melanin synthesis and distribution)]]> 2022-11-04 00:48:23 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369318660 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369333866 OCA 1 is an autosomal recessive disorder in which the biosynthesis of melanin is reduced due to low/no activity of tyrosinase enzyme. ]]> 2022-11-04 01:02:31 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369333866 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369338188 OCA 1 is associated with Missense mutation (a single base pair substitution alters the genetic code that results in the production of an amino acid different from the original one), causing a complete lack of tyrosinase activity]]> 2022-11-04 01:06:18 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369338188 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369361793 Up to date, no cure for OCA exists. Though there are treatments that focus on getting proper eye care and monitoring skin for signs of abnormalities.]]> 2022-11-04 01:24:42 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369361793 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369371105 Research using animal model systems is now being done to either surgically or pharmacologically optimize vision and protect the skin. ]]> 2022-11-04 01:32:00 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369371105 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369374328 2022-11-04 01:34:51 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369374328 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369392513 2022-11-04 01:50:24 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369392513 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369414582 2022-11-04 02:07:39 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369414582 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369422384 2022-11-04 02:13:39 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369422384 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369440301 2022-11-04 02:28:01 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369440301 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369466929 Experimenting therapies on animals provided results and are to be applied to Humans in the near future]]> 2022-11-04 02:48:50 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369466929 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369481805 2022-11-04 03:00:27 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369481805 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369484098 2022-11-04 03:02:20 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2369484098 maryamrashid2 https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2372093728 2022-11-06 23:48:11 UTC https://padlet.com/maryamrashid2/a1rs1c7e7gd3r7f4/wish/2372093728