Anaphylaxis by Julia Colucci https://padlet.com/jmcoluc12/9l959jip4166sski en-us 2022-10-03 22:22:45 UTC 2025-09-30 12:34:57 UTC hello@padlet.com Systemic (Generalized) Symptoms suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324754948 Itching
Erythema
Headaches
Vomiting
Abdominal cramps
Diarrhea
Breathing Difficulty]]> 2022-10-04 00:50:28 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324754948 Severe Reactions suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324756728 Smooth muscle bronchial contraction
Laryngeal edema
Vascular collapse
Reduced blood pressure
Shock
Death]]> 2022-10-04 00:52:16 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324756728 jewolf7 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324759324
Both:
  • Need exposure to antigen (usually environmental) at least once, (sensitization stage)
  • Mediated by IgE
  • Happens within 24 hours (effect stage)
  • Are an imbalanced reaction to stimuli systemic and local
Anaphylaxis Specific:
  •  the most dramatic, happens within minutes
  • Idiopathic Anaphylaxis: "without known exposure to common allergens" (AAFA)
  • Exercise Induced Anaphylaxis: very rare, vigorous exercise is trigger, other environmental factors could be contributing to response 

]]> 2022-10-04 00:54:54 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324759324 Cutaneous (Localized) Symptoms suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324762206 Pain
Swelling
Redness]]> 2022-10-04 00:57:31 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324762206 jmcoluc12 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324763889 Here is a quick video summarizing Anaphylaxis. In this video it reviews the pathophysiology, as well as the specific categorical "type" of hypersensitivity reaction that it is. Signs/Symptoms are discussed and Interventions are mentioned to provide a clear understanding for those who already have or may experience this in the future. ]]> 2022-10-04 00:59:02 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324763889 jmcoluc12 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324813989
  • Allergen attaches to antibody that is linked to a B cell
  • That body responds by producing IgE antibodies against the allergen 
  • IgE molecules bind to receptors located on the mast cells and basophils
  • Now that the basophil/mast cell is layered with these antibodies, an exposure to the same allergen will result in the allergen binding to adjacent IgE molecules, which conjoins the receptors
  • A cascade signal is sent out through the body which triggers the release of mediators like histamine that produce arachidonic acid metabolites like prostaglandins
  • Histamine plays a role in stimulating vasodilation and increasing heart rate
  • Prostaglandins play a role in bronchoconstriction, pulmonary and coronary vasoconstriction, and a peripheral vasodilator

    • ]]>     2022-10-04 01:43:43 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324813989     Drug Related: jmcoluc12 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324817608 Immediate injection of epinephrine 
    • Increases blood flow, widens airways, and may relieve some symptoms temporarily 
    Antihistamines
    • Relieve symptoms of allergies including fever, hives, conjunctivitis
    Beta-agonists
    • Alleviate bronchoconstriction 
    Vasopressors
    • Helps correct hypotension
    ]]>     2022-10-04 01:47:11 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324817608     jmcoluc12 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324824786
  • Genetic predisposition: family anaphylaxis, allergies, asthma, or hypersensitivity reactions
  • Personal history of hypersensitivity reactions, allergies, asthma, or anaphylaxis
  • Previous exposure to antigen
    • ]]>     2022-10-04 01:53:48 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2324824786     suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325803051 Vascular Effects
    • Increased capillary permeability (cytokines, histamine) 
    • Leukocyte emigration (Cytokines)
    • Vasodilation of smooth muscles (Leukotrienes)
      • bronchoconstriction

    Respiratory & GI tracts:
    • Susceptible to eosinophil "invasion". Triggers bone marrow production and release of more eosinophils to the blood. 
    • Increased mucus secretions
    • Narrowing of the airway (bronchoconstriction) & increased edema in the larynx

    Systemic Effects
    • Relative Hypovolemia (low blood volume) 
    • Decreased cardiac output (hypotension)
    • Decreased tissue profusion 
    • Impaired cellular metabolism
    • Shock & Death
    ]]>     2022-10-04 14:20:15 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325803051     Management of Severe Cases of Anaphylaxis suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325810324 Identify triggers
    Determine if genetic factors present
    Prevention of recurrence]]>     2022-10-04 14:23:19 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325810324     suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325819804 Cerbral, renal, or hepatic ischemia and possible organ failure if not treated]]> 2022-10-04 14:27:31 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325819804 suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325835814 2022-10-04 14:35:14 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325835814 suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325847759
  • Monitor patients after injections or vaccines for potential anaphylaxis symptoms
  • Consider allergy test via Allergist or Immunologist following an anaphylaxis reaction or if you are at high risk for allergies
    • ]]>     2022-10-04 14:40:51 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325847759     Common Anaphylaxis Triggers suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325861644 2022-10-04 14:47:28 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2325861644 Type 1 Hypersensitivity Reaction jewolf7 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326203055 2022-10-04 17:43:13 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326203055 suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326212173 Hammett, E. (2022, May 26). Food allergies and anaphylaxis. Online First Aid. https://onlinefirstaid.com/food-allergies-and-anaphylaxis/ ]]> 2022-10-04 17:48:26 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326212173 suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326244440 Harding, M., Kwong, J., Roberts, D., Hagler, D., Reinisch, C., Hoy, H., & Ng, Y. C. (2020). Chapter 13 Immune Responses and Transplantation. In Lewis's medical-surgical nursing: Assessment and management of clinical problems (11th ed., pp. 194–195). essay, Elsevier, Inc. ]]> 2022-10-04 18:06:09 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326244440 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326258730 Pflipsen, M. C., & Vega Colon, K. M. (2020). Anaphylaxis: Recognition and Management. American family physician, 102(6), 355–362.]]> 2022-10-04 18:14:16 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326258730 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326274474 2022-10-04 18:22:55 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326274474 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326280556 Nationwide Children's Hospital. (2022). How to Use An EpiPen. https://www.nationwidechildrens.org/family-resources-education/health-wellness-and-safety-resources/resources-for-parents-and-kids/how-to-use-an-epipen ]]> 2022-10-04 18:26:28 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326280556 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326287615 This video provides clear instructions on how to utilize the EpiPen so users of all ages can follow the steps. It also shows the location and demonstration for the insertion of the EpiPen. By providing knowledge of this skill, it can be a matter of life or death for an individual. ]]> 2022-10-04 18:30:39 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326287615 suziedoza https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326291569 Huether, S., McCance, K., & Rote, N. S. (2019). Chapter 9 Alterations in Immunity and Inflammation. In Pathophysiology: The Biologic Basis of Disease in Adults and Children (8th ed., pp. 256–257). essay, Elsevier. ]]> 2022-10-04 18:33:09 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326291569 jewolf7 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326583858 Abbas, M., Moussa, M., & Akel, H. (2022, January). Type I Hypersensitivity Reaction. NIH National Library of Medicine. https://www.ncbi.nlm.nih.gov/books/NBK560561/# ]]> 2022-10-04 23:17:18 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326583858 jewolf7 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326584512 American Academy of Allergy Asthma and Immunology. (n.d.). Feel Better. Live Better. See and Allergist/Immunologist. https://www.aaaai.org/Tools-for-the-Public/Conditions-Library/Allergies/Feel-Better-Live-Better-See-an-Allergist-Immunolog 

    American Academy of Allergy Asthma and Immunology. (n.d.). Anaphylaxis. https://www.aaaai.org/conditions-treatments/allergies/anaphylaxis
    ]]>     2022-10-04 23:18:18 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326584512     jewolf7 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326584680 Asthma and Allergy Foundation of America. (2017, February). ANAPHYLAXIS: A Severe Allergic Reaction. https://www.aafa.org/anaphylaxis-severe-allergic-reaction/ ]]> 2022-10-04 23:18:33 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326584680 jewolf7 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326584842 Vaillant, A. A. J., Vashisht, R., & Zito, P. M. (2022, January). Immediate Hypersensitivity Reactions. NIH National Library of Medicine. https://pubmed.ncbi.nlm.nih.gov/30020687/ ]]> 2022-10-04 23:18:48 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2326584842 https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2327672167 YouTube. (2021). Anaphylaxis, Animation . YouTube. Retrieved October 5, 2022, from https://www.youtube.com/watch?v=5Sn4bi3t7YE. ]]> 2022-10-05 14:14:08 UTC https://padlet.com/jmcoluc12/9l959jip4166sski/wish/2327672167