Knockout Rat by Kelson Oswald https://padlet.com/2037284/915457eyjpluf9e Knockout Meaning: knockout rats are rats that have a certain gene inactivated for the purpose of studying how it can influence all of the processes in the body. en-us 2020-12-02 21:11:48 UTC 2020-12-02 21:44:17 UTC hello@padlet.com https://padlet.net/icons/png/1f401.png The knockout rat 2037284 https://padlet.com/2037284/915457eyjpluf9e/wish/981787736 A knockout rat is a rat with a single gene turned off through a targeted mutation (gene trapping) used for academic and pharmaceutical research.]]> 2020-12-02 21:18:48 UTC https://padlet.com/2037284/915457eyjpluf9e/wish/981787736 Why/who does it benefit? 2037284 https://padlet.com/2037284/915457eyjpluf9e/wish/981791660 Many rat genes are very similar to those of humans. This makes it possible for genetic researchers to gain a greater understanding of human DNA and physiology by studying knockout genes in lab rats.]]> 2020-12-02 21:20:10 UTC https://padlet.com/2037284/915457eyjpluf9e/wish/981791660 Why rats? 2037284 https://padlet.com/2037284/915457eyjpluf9e/wish/981801024 Mice have been used by the scientific community before. however, rats were discovered to respond much better to tests because of their similarities in genes to humans.]]> 2020-12-02 21:23:31 UTC https://padlet.com/2037284/915457eyjpluf9e/wish/981801024 When were knockout rats first used? 2037284 https://padlet.com/2037284/915457eyjpluf9e/wish/981808480 While the idea of Knockout rats has been around for a while, it wasn't until 2008 that they were used.]]> 2020-12-02 21:26:24 UTC https://padlet.com/2037284/915457eyjpluf9e/wish/981808480 What are the benefits of using these rats? 2037284 https://padlet.com/2037284/915457eyjpluf9e/wish/981815706 Rats have been used in scientific studies for a long time and the anatomy and physiology of rats is widely known allowing scientists to reach more accurate conclusions in translational research.]]> 2020-12-02 21:29:10 UTC https://padlet.com/2037284/915457eyjpluf9e/wish/981815706 The risks and benefits 2037284 https://padlet.com/2037284/915457eyjpluf9e/wish/981829868 Benefits: Rats are already in most labs and are very easy to work with.
Risks:  About 15 percent of gene knockouts are developmentally lethal, which means that the genetically altered embryos cannot grow into adult rats. Another risk is that some people/groups believe that Knockout rats and mice being used is unethical. ]]> 2020-12-02 21:34:44 UTC https://padlet.com/2037284/915457eyjpluf9e/wish/981829868 Citations: 2037284 https://padlet.com/2037284/915457eyjpluf9e/wish/981842614 Ingenious. “What Is a Knockout Rat and What Is Its Main Purpose?” Ingenious Targeting Laboratory, 27 May 2020, www.genetargeting.com/rats/what-is-a-knockout-rat/. 

https://www.genome.gov/about-genomics/fact-sheets/Knockout-Mice-Fact-Sheet#:~:text=What%20are%20the%20drawbacks%20of,cannot%20grow%20into%20adult%20mice.
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