Two types of atomic bombs were developed concurrently during the war: a relatively simple gun-type fission weapon and a more complex implosion-type nuclear weapon. The Thin Man gun-type design proved impractical to use with plutonium so a simpler gun-type called Little Boy was developed that used uranium-235, an isotope that makes up only 0.7 percent of natural uranium. Chemically identical to the most common isotope, uranium-238, and with almost the same mass, it proved difficult to separate the two. Three methods were employed for uranium enrichment: electromagnetic, gaseous and thermal. Most of this work was performed at the Clinton Engineer Works at Oak Ridge, Tennessee.

In parallel with the work on uranium was an effort to produce plutonium. After the feasibility of the world's first artificial nuclear reactor was demonstrated in Chicago at the Metallurgical Laboratory, it designed the X-10 Graphite Reactor at Oak Ridge and the production reactors in Hanford, Washington, in which uranium was irradiated and transmuted into plutonium. The plutonium was then chemically separated from the uranium. The Fat Man implosion-type weapon was developed in a concerted design and development effort by the Los Alamos Laboratory.


The first nuclear device ever detonated was an implosion-type bomb at the Trinity test, conducted at New Mexico's Alamogordo Bombing and Gunnery Range on 16 July 1945. Little Boy and Fat Man bombs were used a month later in the atomic bombings of Hiroshima and Nagasaki, respectively. In the immediate postwar years, the Manhattan Project conducted weapons testing at Bikini Atoll as part of Operation Crossroads, developed new weapons, promoted the development of the network of national laboratories, supported medical research into radiology and laid the foundations for the nuclear navy. It maintained control over American atomic weapons research and production until the formation of the United States Atomic Energy Commission in January 1947.